N-(2-aminoethyl)-1 Aziridine-ethanamine

N-(2-aminoethyl)-1 Aziridine-ethanamine Uses, Dosage, Side Effects, Food Interaction and all others data.

First described in the literature in 2004, N-(2-aminoethyl)-1 Aziridine-ethanamine is an experimental angiotensin converting enzyme 2 inhibitor investigated for its use in treating cardiovascular disease and its activity against Severe Acute Respiratory Syndrome (SARS).

N-(2-aminoethyl)-1 Aziridine-ethanamine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	N-(2-aminoethyl)-1 Aziridine-ethanamine
Generic	N-(2-Aminoethyl)-1-aziridineethanamine
N-(2-Aminoethyl)-1-aziridineethanamine Other Names	N-(2-((2-Aminoethyl)amino)ethyl)aziridine, N-(2-aminoethyl)-1 aziridine-ethanamine
Type
Formula	C₆H₁₅N₃
Weight	Average: 129.207 Monoisotopic: 129.126597495
Groups	Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

N-(2-aminoethyl)-1 Aziridine-ethanamine is an experimental ACE2 inhibitor for the treatment of cardiovascular disease and Severe Acute Respiratory Syndrome.

This experimental drug was being researched for its use in the treatment of cardiovascular disease and SARS-CoV infections.

How N-(2-aminoethyl)-1 Aziridine-ethanamine works

Angiotensin II constricts coronary blood vessels and is positively inotropic, which under normal circumstances, would increase vascular resistance and oxygen consumption. This action can eventually lead to myocyte hypertrophy and vascular smooth muscle cell proliferation. N-(2-aminoethyl)-1 Aziridine-ethanamine may inhibit ACE2, preventing these actions from occurring.

N-(2-aminoethyl)-1 Aziridine-ethanamine binding to ACE2 may lead to a conformational change in ACE2, shifting the residues that would bind SARS-CoV S-glycoprotein, preventing viral attachment and entry.