Nafcillin Sodium Sandoz
Nafcillin Sodium Sandoz Uses, Dosage, Side Effects, Food Interaction and all others data.
A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive Staphylococcus aureus infections .
Nafcillin Sodium Sandoz is a semisynthetic antibiotic substance derived from 6-amino-penicillanic acid. The drugs in this class are highly resistant to inactivation by staphylococcal penicillinase and are active against penicillinase-producing and non penicillinase-producing strains of Staphylococcus species.
| Trade Name | Nafcillin Sodium Sandoz |
| Availability | Prescription only |
| Generic | Nafcillin |
| Nafcillin Other Names | Nafcilina, Nafcillin, Nafcilline, Nafcillinum, Naphcillin |
| Related Drugs | amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, Augmentin |
| Type | |
| Formula | C21H22N2O5S |
| Weight | Average: 414.475 Monoisotopic: 414.124942514 |
| Protein binding | The degree of nafcillin binding to serum proteins is 89.9 ± 1.5%, where it is mainly bound to albumin . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | USA |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Nafcillin Sodium Sandoz is a penicillin derivative antibiotic used to treat susceptible staphylococcal infections.
Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Nafcillin Sodium Sandoz is also used to associated treatment for these conditions: Bacterial Infections
How Nafcillin Sodium Sandoz works
Like other penicillins, nafcillin exerts a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication in the bacterial cell wall synthesis . It inhibits the biosynthesis of the bacterial cell wall by forming covalent bonds with penicillin-binding proteins that play a critical role in the final transpeptidation process. Binding to penicillin-binding proteins inhibits the transpeptidase and carboxypeptidase activities conferred by these proteins and prevents the formation of the crosslinks .
Toxicity
Serious toxicity is unlikely following large doses of nafcillin. Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses. The oral LD50 in rats is >5000mg/kg and the intravenous LD50 in rats is >1000mg/kg .
Food Interaction
- Take on an empty stomach. Food may make the absorption of oral nafcillin unpredictable.
[Moderate] ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food.
The therapeutic effect of the antimicrobial may be reduced.
MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals.
Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.
Nafcillin Sodium Sandoz Hypertension interaction
[Moderate] Each gram of parenteral nafcillin sodium contains approximately 67 mg (2.9 mEq) of sodium and is buffered with 40 mg of sodium citrate.
Each 250 mg capsule of nafcillin sodium contains approximately 17 mg (0.7 mEq) of sodium buffered with calcium carbonate.
The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
In addition, hypokalemia has been reported rarely during therapy with the penicillinase-resistant penicillins, which may be particularly important to bear in mind when treating patients with low potassium reserves or fluid and electrolyte imbalance.
Clinical monitoring of electrolytes is recommended if these agents are used for prolonged periods.
Nafcillin Sodium Sandoz Drug Interaction
Major: warfarin, warfarinUnknown: amoxicillin / clavulanate, amoxicillin / clavulanate, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, meperidine, meperidine, insulin lispro, insulin lispro, insulin glargine, insulin glargine, furosemide, furosemide, escitalopram, escitalopram, esomeprazole, esomeprazole, sodium chloride, sodium chloride
Nafcillin Sodium Sandoz Disease Interaction
Major: colitis, marrow toxicityModerate: renal/liver disease, sodium/potassium
Volume of Distribution
Nafcillin Sodium Sandoz is reported to be widely distributed in various body fluids, including bile, pleural, amniotic and synovial fluids .
Elimination Route
Following intravenous administration of 500mg nafcillin, the mean plasma concentration was approximately 30 µg/mL. This value was reached after 5 minutes of injection .
Half Life
The serum half-life of nafcillin administered by the intravenous route ranged from 33 to 61 minutes as measured in three separate studies.
Elimination Route
Nafcillin Sodium Sandoz is primarily eliminated by non-renal routes, namely hepatic inactivation and excretion in the bile.
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