Narebox

Narebox Uses, Dosage, Side Effects, Food Interaction and all others data.

Narebox is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Narebox has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.

Narebox is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class. Narebox is an a-ariloxybenzyl derivative of morpholine. Narebox is primarily used to treat depression but has also been found useful in the treatment of narcolepsy and panic disorders.

Trade Name Narebox
Generic Reboxetine
Reboxetine Other Names Reboxetina, Reboxetine
Weight 2mg, 4mg
Type Tablet
Formula C19H23NO3
Weight Average: 313.397
Monoisotopic: 313.167793605
Protein binding

98%

Groups Approved, Experimental
Therapeutic Class
Manufacturer Zydus Cadila Healthcare Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Narebox
Narebox

Uses

Narebox is a drug used for the acute treatment of major depression and for maintenance therapy of depression.

For the treatment of clinical depression.

Narebox is also used to associated treatment for these conditions: Major Depressive Disorder (MDD), Maintenance

How Narebox works

Narebox is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine. Narebox does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.

Toxicity

Reports of seizures (rare) have been reported

Elimination Route

Narebox is rapidly and extensively absorbed following oral administration.

Half Life

12.5 hours

Innovators Monograph

You find simplified version here Narebox

*** Taking medicines without doctor's advice can cause long-term problems.
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