Narebox
Narebox Uses, Dosage, Side Effects, Food Interaction and all others data.
Narebox is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Narebox has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.
Narebox is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class. Narebox is an a-ariloxybenzyl derivative of morpholine. Narebox is primarily used to treat depression but has also been found useful in the treatment of narcolepsy and panic disorders.
| Trade Name | Narebox |
| Generic | Reboxetine |
| Reboxetine Other Names | Reboxetina, Reboxetine |
| Weight | 2mg, 4mg |
| Type | Tablet |
| Formula | C19H23NO3 |
| Weight | Average: 313.397 Monoisotopic: 313.167793605 |
| Protein binding | 98% |
| Groups | Approved, Experimental |
| Therapeutic Class | |
| Manufacturer | Zydus Cadila Healthcare Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Narebox is a drug used for the acute treatment of major depression and for maintenance therapy of depression.
For the treatment of clinical depression.
Narebox is also used to associated treatment for these conditions: Major Depressive Disorder (MDD), Maintenance
How Narebox works
Narebox is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine. Narebox does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.
Toxicity
Reports of seizures (rare) have been reported
Elimination Route
Narebox is rapidly and extensively absorbed following oral administration.
Half Life
12.5 hours
Innovators Monograph
You find simplified version here Narebox
