Natacyn

Natacyn Uses, Dosage, Side Effects, Food Interaction and all others data.

Natacyn is a tetraene polyene antibiotic derived from Streptomyces natalensis. Natacyn probably exerts its antifungal effects by binding to sterols in the fungal cell membrane to produce a change in membrane permeability that allows loss of essential cellular constituents. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, Natacyn is predominantly fungicidal. Topical administration appears to produce effective concentration of Natacyn within the corneal stroma but not in intraocular fluid.

Natacyn is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natacyn is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Trade Name Natacyn
Generic Natamycin
Natamycin Other Names Natamicina, Natamycin, Natamycine, Natamycinum, Pimaracin, Pimaricin
Weight 5%,
Type Ophthalmic suspension
Formula C33H47NO13
Weight Average: 665.733
Monoisotopic: 665.304740577
Groups Approved
Therapeutic Class Ophthalmic antibacterial drugs
Manufacturer
Available Country United States,
Last Updated: September 19, 2023 at 7:00 am
Natacyn
Natacyn

Uses

Natacyn sterile ophthalmic suspension is used for the treatment of fungal blepharitis, conjunctivitis and keratitis caused by susceptible organisms including Fusarium solani.

Natacyn is also used to associated treatment for these conditions: Fungal Keratitis, Fungal blepharitis, Fungal conjunctivitis

How Natacyn works

Like other polyene antibiotics, Natacyn inhibits fungal growth by binding to sterols. Specifically, Natacyn binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.

Dosage

Natacyn dosage

For fungal keratitis: The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval. The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated.

For fungal blepharitis & conjunctivitis: Less frequent initial dosage, 1 drop 4-6 times daily may be sufficient.

Side Effects

Eye irritation, eye discomfort, eye edema, conjunctival chemosis and hyperemia has been reported.

Precaution

For topical eye use only. Failure of improvement of keratitis following 7-10 days of administration of the drug suggests that the infection may be caused by a microorganism not susceptible to natamycin.

Interaction

May increase spread of fungal eye infection when used with topical corticosteroid.

Food Interaction

No interactions found.

Elimination Route

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Pregnancy & Breastfeeding use

Pregnancy Category C. Natacyn sterile ophthalmic suspension should be given to a pregnant woman only if clearly needed.

Lactation: It is not known whether this drug is excreted in human milk. Caution should be exercised when Natacyn is administered to a nursing mother.

Contraindication

Natacyn ophthalmic suspension is contraindicated in individuals with a history of hypersensitivity to any of its component.

Special Warning

Pediatric: Safety and effectiveness in paediatric patients have not been established.

Storage Condition

Store in a cool and dry place. Protect from light. Do not freeze. Do not use for longer than one month after first opening of the bottle.

Innovators Monograph

You find simplified version here Natacyn

Natacyn contains Natamycin see full prescribing information from innovator Natacyn Monograph, Natacyn MSDS, Natacyn FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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