Natrii Valproas, Maagsapresistente Tabletten

Natrii Valproas, Maagsapresistente Tabletten Uses, Dosage, Side Effects, Food Interaction and all others data.

Natrii Valproas, Maagsapresistente Tabletten shows antiepileptic properties in various types of seizures. The exact mechanism of Natrii Valproas, Maagsapresistente Tabletten is not yet established. However it is suggested that its activity is related to increased brain levels of Gama Amino Butyric Acid (GABA).

Natrii Valproas, Maagsapresistente Tabletten
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Natrii Valproas, Maagsapresistente Tabletten
Generic	Sodium Valproate
Type
Therapeutic Class	Primary anti-epileptic drugs
Manufacturer	Sanofi
Available Country	Netherlands
Last Updated:	September 19, 2023 at 7:00 am

Uses

Natrii Valproas, Maagsapresistente Tabletten is used for -

Epilepsy: All types of epilepsy such as Absence seizure, Myoclonic seizure, Tonic-clonic seizure, Atonic, Mixed, simple or generalized, Secondary generalized seizure etc.
Mania: For the treatment of manic episodes of bipolar disorders.
Other: As an alternative treatment for febrile convulsion & migraine prophylaxis.

Dosage

Natrii Valproas, Maagsapresistente Tabletten dosage

Oral:

Adults:

Initial: 600 mg/day in 2 divided doses, preferably after food. Dose may be increased by 200mg/day at 3 days interval to a maximum of 2.5 gm daily in divided doses until control of seizure is achieved.
Maintenance dose: Usually 1-2 gm daily (20-30 mg/kg daily).

Children (up to 20 kg):

Initial: 20 mg/kg daily in divided doses. Dose may be increased in severe cases with proper monitoring of plasma concentration.

Children (over 20 kg):

Initial: 400 mg/ day (irrespective of weight). Dose may be increased by 20-30 mg/ kg if required to achieve control.

Injection:

Natrii Valproas, Maagsapresistente Tabletten is for intravenous use only. Use of Natrii Valproas, Maagsapresistente Tabletten for periods of more than 14 days has not been studied. Patients should be switched to oral valproate products as soon as it is clinically feasible.

Natrii Valproas, Maagsapresistente Tabletten should be administered as a 60 minute infusion (but not more than 20 mg/min) with the same frequency as the oral products, although plasma concentration monitoring and dosage adjustments may be necessary.

In one clinical safety study, approximately 90 patients withepilepsyand with no measurable plasma levels of valproate were given single infusions of Natrii Valproas, Maagsapresistente Tabletten (up to 15 mg/kg and mean dose of 1184 mg) over 5-10 minutes (1.5-3.0 mg/kg/min). Patients generally tolerated the more rapid infusions well. This study was not designed to assess the effectiveness of these regimens.

Side Effects

Gastric irritation, nausea, ataxia & tremor; hyperammonaemia, increased appetite & weight gain; transient hair loss, oedema, thrombocytopenia, and inhibition of platelet aggregation, impaired hepatic function leading rarely to fetal hepatic failure; rashes; sedation; rarely lethargy and confusion and also increased alertness; rarely pancreatitis, leucopenia, pancytopenia, red cell hypoplasia, fibrinogen reduction; irregular periods, amenorrhoea, gynaecomastia, toxic epidermal necrolysis, hearing loss, Fancoli's syndrome, dementia, Steven's-Johnson syndrome, and vasculitis have also been reported.

Precaution

Liver function should be monitored before therapy and during first six months, especially in those patients who seem most at risk. Blood tests are recommended before surgery. Renal impaired patients, pregnant and brest feeding mother should be specially cared. Valproate is eliminated mainly through the kidney, partly in the form of ketone bodies which may lead to false statement in urine ketone test. Sudden withdrawal of therapy should be avoided

Interaction

Natrii Valproas, Maagsapresistente Tabletten is a non specific inhibitor of drug metabolism. Phenobarbital, Phenytoin, Warfarin, Aspirin etc. interacts with Natrii Valproas, Maagsapresistente Tabletten.

Pregnancy & Breastfeeding use

Natrii Valproas, Maagsapresistente Tabletten crosses the placenta in humans which may lead to neural tube defects such as anencephaly and spina bifida if exposed in the first trimester. Natrii Valproas, Maagsapresistente Tabletten may excrete in breast milk. So treatment with Natrii Valproas, Maagsapresistente Tabletten may cause harm to new born baby.

Contraindication

Natrii Valproas, Maagsapresistente Tabletten is contra-indicated in patients with known hypersensitivity of Natrii Valproas, Maagsapresistente Tabletten, personal or family history of severe active liver disease, hepatic dysfunction, porphyria and known urea cycle disorder.

Storage Condition

Syrup: Store below 30° C, protected from light.

Tablet: Store below 30° C, protected from light. Keep all medicines out of the reach of children.

Innovators Monograph

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FAQ

What is Natrii Valproas, Maagsapresistente Tabletten used for?

Natrii Valproas, Maagsapresistente Tabletten used to treat epilepsy and bipolar disorder. It's occasionally used to prevent migraine headaches. This medicine is only available on prescription.

How safe is Natrii Valproas, Maagsapresistente Tabletten?

Many people can take Natrii Valproas, Maagsapresistente Tabletten safely for many months or years. However, there are potential side effects that can happen over a long time. Long-term treatment with Natrii Valproas, Maagsapresistente Tabletten can cause osteoporosis and osteopenia.

How long does it take for sodium valproate to work?

Natrii Valproas, Maagsapresistente Tabletten may take several days to show an initial effect and in some cases may take from two to six weeks for maximum effect. Treatment is started with low doses and may be increased over a couple of weeks according to your child's response.

What are the common side effects of Natrii Valproas, Maagsapresistente Tabletten?

The common side effects of Natrii Valproas, Maagsapresistente Tabletten are include:

stomach pain, feeling or being sick
diarrhoea
dry or sore mouth, or swollen gums
shakes (tremors) in a part of your body, or unusual eye movements
feeling tired or sleepy
headache
weight gain
thinning hair, or changes to the colour or texture of your hair
irregular or delayed periods

How to take Natrii Valproas, Maagsapresistente Tabletten?

Natrii Valproas, Maagsapresistente Tabletten comes as slow release (prolonged or sustained release) tablets, capsules and granules, gastro-resistant tablets, crushable tablets, and as a liquid.
Slow release medicine passes into your body gradually.

When is the best time to take Natrii Valproas, Maagsapresistente Tabletten?

You can take Natrii Valproas, Maagsapresistente Tabletten with or without food, but it's best to stick to the same way each time. Do not take it with food some days and without food on other days.

How often can I take Natrii Valproas, Maagsapresistente Tabletten?

If you're taking Natrii Valproas, Maagsapresistente Tabletten once a day, you can choose a time that suits you. Just try to keep to the same time every day.
If you're taking Natrii Valproas, Maagsapresistente Tabletten twice a day, try to leave a gap of 10 to 12 hours between doses. For example you could take your first dose in the morning (between 7am and 8am) and your second dose in the evening (between 7pm and 8pm).

Is Natrii Valproas, Maagsapresistente Tabletten safe during pregnancy?

Natrii Valproas, Maagsapresistente Tabletten is not recommended in pregnancy, as it can cause birth defects and problems with your baby's learning and behaviour.
If there's a chance you could become pregnant while taking this medicine, your doctor will put you on Prevent, the Natrii Valproas, Maagsapresistente Tabletten prevention programme.

Is Natrii Valproas, Maagsapresistente Tabletten safe during breastfeeding?

If your doctor or health visitor says your baby is healthy you can take Natrii Valproas, Maagsapresistente Tabletten while breastfeeding.
Natrii Valproas, Maagsapresistente Tabletten passes into breast milk in small amounts but it's unlikely to harm your baby so you can continue breastfeeding if your doctor says you need to take it.

How long will I take Natrii Valproas, Maagsapresistente Tabletten?

Once your condition is under control, you'll usually need to keep taking Natrii Valproas, Maagsapresistente Tabletten for many years.

Is Natrii Valproas, Maagsapresistente Tabletten safe to take it for a long time?

Many people can take Natrii Valproas, Maagsapresistente Tabletten safely for many months or years.
However, there are potential side effects that can happen over a long time. Long-term treatment with Natrii Valproas, Maagsapresistente Tabletten can cause osteoporosis and osteopenia.

What will happen when I come off Natrii Valproas, Maagsapresistente Tabletten?

Do not stop taking Natrii Valproas, Maagsapresistente Tabletten suddenly, unless your doctor tells you to.
You're unlikely to get any extra symptoms when you stop taking this medicine. However, if you're taking Natrii Valproas, Maagsapresistente Tabletten for epilepsy, it's possible that you'll get seizures again once you stop taking it. You can prevent these withdrawal seizures by reducing your dose of Natrii Valproas, Maagsapresistente Tabletten gradually.

Can I drink alcohol with Natrii Valproas, Maagsapresistente Tabletten?

Drinking alcohol while taking Natrii Valproas, Maagsapresistente Tabletten may make you feel sleepy or tired. It's best to stop drinking alcohol during the first few days, until you see how the medicine affects you.

Will Natrii Valproas, Maagsapresistente Tabletten affect my fertility?

Natrii Valproas, Maagsapresistente Tabletten can reduce fertility in both men and women. Once you stop taking this medicine, your fertility will return.In men Natrii Valproas, Maagsapresistente Tabletten has been reported to cause infertility.

Will Natrii Valproas, Maagsapresistente Tabletten affect my contraception?

Natrii Valproas, Maagsapresistente Tabletten does not affect any type of contraception, including the combined pill and emergency contraception.If there's a chance you could become pregnant while taking Natrii Valproas, Maagsapresistente Tabletten you must use contraception. Your doctor will put you on Prevent, the valproate pregnancy prevention programme.

Can I drive after taking Natrii Valproas, Maagsapresistente Tabletten?

You may feel sleepy, tired or dizzy when you first start taking Natrii Valproas, Maagsapresistente Tabletten. This may also happen if your dose has increased. If you're affected, do not drive or ride a bike until you feel more alert.

Can I take too much dose of Natrii Valproas, Maagsapresistente Tabletten?

Taking too much Natrii Valproas, Maagsapresistente Tabletten can lead to symptoms such as: feeling or being sick, headaches or feeling dizzy,muscle weakness.

What happen If I missed Natrii Valproas, Maagsapresistente Tabletten?

If you've missed a dose, what you do next depends on whether you usually take your medicine once or twice a day. If you take Natrii Valproas, Maagsapresistente Tabletten once a day ,take the forgotten dose as soon as you remember unless it's within a few hours of the next dose.