Navane
Navane Uses, Dosage, Side Effects, Food Interaction and all others data.
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Navane is an antipsychotic of the thioxanthene series. Navane possesses certain chemical and pharmacological similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines. Although widely used in the treatment of schizophrenia for several decades, thiothixene is seldom used today in favor of atypical antipsychotics such as risperidone.
| Trade Name | Navane |
| Availability | Prescription only |
| Generic | Thiothixene |
| Thiothixene Other Names | cis-thiothixene, Thiothixene, Tiotixene, Tiotixeno, Tiotixenum |
| Related Drugs | quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, haloperidol, prochlorperazine, Haldol, Compazine |
| Weight | 1mg, 10mg, 2mg, 5mg, |
| Type | Oral, Oral Capsule |
| Formula | C23H29N3O2S2 |
| Weight | Average: 443.625 Monoisotopic: 443.170118567 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Navane is an antipsychotic indicated for the management of schizophrenia.
For the management of schizophrenia.
Navane is also used to associated treatment for these conditions: Schizophrenia
How Navane works
Navane acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Toxicity
Symptoms of overdose include central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, and weakness.
Food Interaction
- Avoid alcohol.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Navane Drug Interaction
Moderate: aripiprazole, lorazepam, buspirone, duloxetine, haloperidol, lamotrigine, furosemide, lurasidone, escitalopram, fluoxetine, mirtazapine, quetiapine, cariprazine, alprazolamUnknown: fluticasone / salmeterol, rosuvastatin, omega-3 polyunsaturated fatty acids, ferrous sulfate, atomoxetine, cholecalciferol
Navane Disease Interaction
Major: dementia, acute alcohol intoxication, cardiovascular disease, CNS depression, NMS, tardive dyskinesia, CNS depression, hematologic toxicityModerate: seizure, anticholinergic effects, dehydration, hyperprolactinemia, liver disease, parkinsonism, breast cancer, convulsions, dystonia, hyperprolactinemia, liver impairment, NMS, parkinsonism, respiratory disorders
Half Life
10-20 hours
Innovators Monograph
You find simplified version here Navane
