Navidoxine (Mebeverine)
Navidoxine (Mebeverine) Uses, Dosage, Side Effects, Food Interaction and all others data.
Navidoxine (Mebeverine) is a musculotropic antispasmodic agent used to relieve cramps or spasms of the stomach and intestine (gut). It is particularly useful in treating Irritable Bowel Syndrome (IBS) and similar conditions. It works by relaxing the muscles and helping to restore the normal movement of the gut.
| Trade Name | Navidoxine (Mebeverine) |
| Generic | Mebeverine |
| Mebeverine Other Names | Mebeverina, Mebeverine, Mebeverinum |
| Type | |
| Formula | C25H35NO5 |
| Weight | Average: 429.557 Monoisotopic: 429.251523231 |
| Groups | Approved, Investigational |
| Therapeutic Class | Anticholinergics |
| Manufacturer | |
| Available Country | Malta |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the symptomatic treatment of Irritable Bowel Syndrome (IBS) and other conditions include:
- Chronic irritable colon
- Spastic constipation
- Mucous colitis
- Colicky abdominal pain
- Persistent non-specific diarrhea
Navidoxine (Mebeverine) is also used to associated treatment for these conditions: Abdominal Pain, Abdominal Spasms, Abnormal Bowel Movement Such as Constipation, Diarrhea, Abdominal Pain, Irritable Bowel Syndrome (IBS), Bowel discomfort
Dosage
Navidoxine (Mebeverine) dosage
135 mg tid, may reduce gradually after several wk when the desired effect has been obtained; 100 mg tid has also been used. As modified-release cap: 200 mg bid.
Navidoxine (Mebeverine) is most effective when taken 20 minutes before meals. After several weeks when the desired effect has been obtained, the dosage may be gradually reduced.
Missed dose: If a dose of this medicine is missed, that should be taken as soon as possible. However, if it is almost time for the next dose, then skip the missed dose and the regular dosing schedule should be maintained. Dose should not be doubled at the same time to compensate the missed dose.
Side Effects
Generally Navidoxine (Mebeverine) is well tolerated. However, few side-effects like skin rash, urticaria and angioedema may appear.
Precaution
Caution should be exercised in porphyria or allergic reaction to this or any other medicine of this group.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
No teratogenicity has been shown in animal experiments. However, the usual precautions concerning the administration of any drug during pregnancy should be exercised. Navidoxine (Mebeverine) does not excrete in the breast milk after administering the therapeutic dose.
Special Warning
Use in children: Navidoxine (Mebeverine) is not recommended in children under 10 years.
Acute Overdose
Symptoms: CNS excitability
Management: Symptomatic and supportive treatment. Gastric lavage may be considered in case of multiple intoxication or if discovered w/in approx 1 hr.
Storage Condition
Store below 30° C.
Innovators Monograph
You find simplified version here Navidoxine (Mebeverine)
Navidoxine (Mebeverine) contains Mebeverine see full prescribing information from innovator Navidoxine (Mebeverine) Monograph, Navidoxine (Mebeverine) MSDS, Navidoxine (Mebeverine) FDA label
FAQ
What is Navidoxine (Mebeverine) used for?
Navidoxine (Mebeverine) helps with muscle spasms. It can be used to ease painful stomach cramps if you have irritable bowel syndrome (IBS) or other conditions.
How safe is Navidoxine (Mebeverine)?
Navidoxine (Mebeverine) is generally safe and you're unlikely to have side effects. Some people may get an itchy rash (hives).
How does Navidoxine (Mebeverine) work?
Navidoxine (Mebeverine) works by relaxing the muscles in your intestine. This relieves the cramps and pain that can be caused by IBS or other conditions.
What are the common side effects of Navidoxine (Mebeverine)?
The common side effects of Navidoxine (Mebeverine) are:
- Nausea.
- Vomiting.
- Rash.
- Headache.
- Heartburn.
- Indigestion.
- Constipation.
- Dizziness.
Is Navidoxine (Mebeverine) safe during pregnancy?
Navidoxine (Mebeverine) are not recommended during pregnancy.
Is Navidoxine (Mebeverine) safe during breastfeeding?
It is usually safe to breastfeed while taking Navidoxine (Mebeverine). Some of the medicine may pass into your breast milk. However, this is in small amounts and unlikely to harm your baby.
Can I drink alcohol with Navidoxine (Mebeverine)?
Yes, you can drink alcohol with Navidoxine (Mebeverine).
When should be best taken of Navidoxine (Mebeverine)?
It's best to take your Navidoxine (Mebeverine) 20 minutes before a meal.
How often can I take Navidoxine (Mebeverine)?
The recommended dose is one tablet three times a day. Do not take more than three tablets per day.
Can I Navidoxine (Mebeverine) take on an empty stomach?
Navidoxine (Mebeverine) should take on an empty stomach. If you take it twice a day, take it before breakfast and dinner. If you take it 3 times a day, take it before breakfast, lunch and dinner.
How long does Navidoxine (Mebeverine) take to work?
Navidoxine (Mebeverine) starts to work after 1 hour. You should feel better 1 to 3 hours after taking it.
What is the half life of Navidoxine (Mebeverine)?
The steady state elimination half-life of DMAC is 2.45 h.
Does Navidoxine (Mebeverine) raise blood pressure?
Navidoxine (Mebeverine) also significantly reduced heart rate and arterial blood pressure.
Can I take Navidoxine (Mebeverine) for a long time?
You will usually only take Navidoxine (Mebeverine) if you are having a flare-up of your IBS symptoms.
Who should not take Navidoxine (Mebeverine)?
The recommended dose is one tablet three times a day. Do not take more than three tablets per day. The number of tablets you take may be lowered if your symptoms improve. Children and adolescents: Navidoxine (Mebeverine) is not recommended for use in children and adolescents below 18 years of age.
What happen If I missed Navidoxine (Mebeverine)?
If you miss a dose of Navidoxine (Mebeverine), skip the missed dose and take the next one as usual. Do not take a double dose to make up for a missed dose. If you forget doses often, it may help to set an alarm to remind you.
What happens if I take too much Navidoxine (Mebeverine)?
If you take too much Navidoxine (Mebeverine) by accident, it is unlikely to harm you. Speak to a pharmacist or doctor if you're worried.
Can I just stop taking Navidoxine (Mebeverine)?
You can stop taking Navidoxine (Mebeverine) when you feel better. This may take up to 2 weeks. If you do not get better within 2 weeks of taking Navidoxine (Mebeverine), or get worse at any time, talk to a doctor.
Does Navidoxine (Mebeverine) raise blood pressure?
Navidoxine (Mebeverine) also significantly reduced heart rate and arterial blood pressure.
Does Navidoxine (Mebeverine) cause tachycardia?
Transient bradycardia followed by tachycardia.
