Nebramycin II
Nebramycin II Uses, Dosage, Side Effects, Food Interaction and all others data.
Nebramycin II is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria. Nebramycin II is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans.
| Trade Name | Nebramycin II |
| Generic | Apramycin |
| Apramycin Other Names | Apramicina, Apramycin, Apramycine, Apramycinum, Nebramycin II |
| Type | |
| Formula | C21H41N5O11 |
| Weight | Average: 539.5771 Monoisotopic: 539.280257179 |
| Groups | Experimental, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Nebramycin II is an aminoglycoside antibiotic for veterinary use that is used to treat infections in animals.
For the treatment of bacterial infections in animals.
How Nebramycin II works
Nebramycin II stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria.
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