Negasunt
Negasunt Uses, Dosage, Side Effects, Food Interaction and all others data.
This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a dip or wash. Coumaphos is widely used for both farm and domestic animals to control ticks, mites, flies and fleas.
Sulfanilamide is a molecule containing the sulfonamide functional group attached to an aniline.
Sulfanilamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
| Trade Name | Negasunt |
| Generic | Coumaphos + Propoxur + Sulfanilamide |
| Weight | vet |
| Type | Dust Powder |
| Therapeutic Class | |
| Manufacturer | Bell Pharma Private Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans.
For the treatment of vulvovaginitis caused by Candida albicans.
Negasunt is also used to associated treatment for these conditions: Vulvovaginal Candidiasis
How Negasunt works
Sulfanilamide is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. This enzyme normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid. The inhibited reaction is normally necessary in these organisms for the synthesis of folic acid. Without it, bacteria cannot replicate.
Toxicity
Oral, mouse LD50 = 3700 mg/kg; Intravenous, mouse LD50 = 621 mg/kg; Oral, rabbit LD50 = 1300 mg/kg. Side effects include itching, burning, skin rash, redness, swelling, or other sign of irritation not present before use of this medicine and long-term use of sulfonamides may cause cancer of the thyroid gland.
Elimination Route
Sulfonamides are absorbed through the vaginal mucosa. There are no pharmacokinetic data available describing how much of an intravaginal dose reaches the systemic circulation.
Innovators Monograph
You find simplified version here Negasunt
