Neo-Angin zuckerfrei
Neo-Angin zuckerfrei Uses, Dosage, Side Effects, Food Interaction and all others data.
Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections , . Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils .
The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition .
The mixture of amylmetacresol throat lozenge medications markedly reduces the infectivity of certain infectious viruses in the throat and in cough droplets, thus reducing opportunities for person-to-person transmission . In addition, it relieves symptoms of sore throat/irritation of the throat , .
Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other hand, dichlorobenzyl alcohol is categorized by the FDA in the inactive ingredient for approved drug products.
In vitro studies with the combination of dichlorobenzyl alcohol and amylmetacresol have shown a virucidal against a number of viruses associated with the common cold which is observed by a reduction in the viral load. In clinical trials, administration of dichlorobenzyl alcohol lozenges has been shown to generate a reduced throat soreness and to provide pain relief and relief from difficulty in swallowing 5 minutes after administration. This effect can last for even 2 hours. The relief effect was shown to reach a steady-state after 45 minutes.
Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration. Menthol mediates anesthetic properties and anti-irritating properties locally, thus it is widely used to relieve minor throat irritations.
Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Menthol induces a cooling sensation on the skin upon inhalation, oral ingestion, or topical application by stimulating the cold-sensitive receptors expressed on the skin, without actually causing a drop in the skin temperature.
| Trade Name | Neo-Angin zuckerfrei |
| Generic | Amylmetacresol + Dichlorobenzyl Alcohol + Levomenthol |
| Type | |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Austria |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Amylmetacresol is an antiseptic used to treat infections in the mouth and throat.
Sore throat, minor mouth and throat infections , , .
Dichlorobenzyl alcohol is a medication used to treat a sore throat.
Dichlorobenzyl alcohol in combination with Amylmetacresol is available in over-the-counter products used for symptomatic relief of acute sore throat and postoperative sore throat.
Menthol is an organic compound used to treat mild to moderate muscle and joint pain.
Used to treat occasional minor irritation, pain, sore mouth, and sore throat as well as cough associated with a cold or inhaled irritants.
Neo-Angin zuckerfrei is also used to associated treatment for these conditions: Canker sores oral, Gingivitis, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Laryngitis, Orofacial Pain, Pharyngitis, Sore Throat, Stomatitis, Mouth infection, Mouth soreness, Pain in throat, Sore throat and hoarseness, Throat infections, Oral antisepsisMouth infection, Throat infections, Oral antisepsisAllergies, Arthritis, Back Pain Lower Back, Backache, Chilblains, Common Cold, Contusions, Cough, Cough caused by Common Cold, Dandruff, Flu caused by Influenza, Generalised muscle aches, Hemorrhoids, Intercostal Pain, Itching caused by Dandruff, Itching of the scalp, Joint Pain, Mild pain, Muscle Fatigue, Muscle Strain, Nasal Congestion, Orofacial Pain, Pain caused by Fracture Bone, Productive cough, Psoriasis, Redness of the scalp, Seborrheic Dermatitis, Shoulder Stiffness, Sore Throat, Soreness, Muscle, Sprains, Stiff Shoulder, Stiff neck, Swelling, Upper Respiratory Tract Infection, Hematomas, Muscle, joint pains, Nonspecific pain, Scalp irritation, Sports Massage
How Neo-Angin zuckerfrei works
The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/protein–lipid interaction is responsible for this action .
Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner .
The use of dichlorobenzyl alcohol has been related to its antibacterial, antiviral and local anesthetic properties. The local anesthetic action of dichlorobenzyl alcohol is thought to be due to a reduced sodium channel blockade. The antiseptic mechanism of action of dichlorobenzyl alcohol is not fully understood but it is thought to be related to a denaturation of external proteins and rearrangement of the tertiary structure proteins.
Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.
Toxicity
Oral LD50: 1500 mg/kg (rat)
Adverse effects include hypersensitivity reactions, tongue soreness .
Occasionally, hypersensitivity reactions may occur, manifested by digestive problems such as nausea or dyspepsia. This is extremely rare .
In the case of overdose, management should be symptomatic. In cases of severe overdosage, gastric lavage may be warranted to empty the stomach contents. Saline laxatives and activated charcoal may be administered orally .
Fertility and mutagenicity studies do not indicate any effect driven by dichlorobenzyl alcohol. Overdose studies indicate that in systemic overdose there might be a presence of a CNS transitory stimulation followed by CNS and cardiovascular. Chronic administration is not recommended as it might alter the normal microbial balance of the throat. depression In rats, the reported LD50 is of about 2.7 g/kg when administered orally.
Menthol, DL: ORAL (LD50): Acute: 2900 mg/kg [Rat], 3100 mg/kg [Mouse]. DERMAL (LD50): Acute: 5001 mg/kg Rabbit.
Volume of Distribution
This pharmacokinetic property has not been fully studied.
Elimination Route
Rapidly absorbed and eliminated .
Dichlorobenzyl alcohol is released almost immediately from its formulation and reaches peak concentration after 3-4 minutes. The concentration in saliva after 120 minutes represents about 50% of the administered dose.
Half Life
This pharmacokinetic property has not been fully studied.
Clearance
This pharmacokinetic property has not been fully studied.
Elimination Route
In preclinical trials, dermal administration of dichlorobenzyl alcohol results in renal elimination of 90% of the administered dose. After metabolism, dichlorobenzyl alcohol is excreted in the urine.
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