Neo Loridin
Neo Loridin Uses, Dosage, Side Effects, Food Interaction and all others data.
Neo Loridin is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Neo Loridin is a long-acting second-generation H1-receptor antagonist which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergies. Neo Loridin blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Neo Loridin does not enter the brain from the blood and, therefore, does not cause drowsiness.
| Trade Name | Neo Loridin |
| Availability | Prescription only |
| Generic | Desloratadine |
| Desloratadine Other Names | Descarboethoxyloratadine, Desloratadina, Desloratadine |
| Related Drugs | prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, diphenhydramine, Zyrtec, Xolair |
| Type | |
| Formula | C19H19ClN2 |
| Weight | Average: 310.821 Monoisotopic: 310.123676325 |
| Protein binding | Desloratadine is bound approximately 82 to 87% to plasma proteins, while its active metabolite, 3-hydroxydesloratadine, is bound approximately 85 to 89%. |
| Groups | Approved, Investigational |
| Therapeutic Class | Non-sedating antihistamines |
| Manufacturer | |
| Available Country | Myanmar |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Allergic Rhinitis: Neo Loridin is used for the relief of the nasal and non-nasal symptoms of allergic rhinitis (Both seasonal and perennial) in patients 2 years of age and older.
Chronic Idiopathic Urticaria: Neo Loridin is also used for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 2 years of age and older.
Neo Loridin is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms, Antihistamine
How Neo Loridin works
Like other H1-blockers, Neo Loridin competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine.
Dosage
Neo Loridin dosage
Pediatric drops :
- Child 6 -11 months of age: 2 ml drops once daily
- Child 1 -2 years of age: 2.5 ml drops once daily
Syrup:
- Child 6-11 months of age: 2 ml once daily
- Child 1-5 years of age: 2.5 ml once daily
- Child 6-11 years of age: 5 ml once daily
- Adults & > 12 years of age: 10 ml once daily
Tablet:
- Adults and children 12 years of age and over: 5 mg daily
Side Effects
Neo Loridin is generally well tolerated. However, dry mouth, fatigue, somnolence and myalgia are commonly reported side-effects. Less common side-effects may include dizziness, headache and nausea. Rarely rash, pruritus and urticaria may occur.
Toxicity
Information regarding desloratadine overdose is limited, although somnolence has been reported. In case of overdose, symptomatic and supportive treatment, including removing the unabsorbed drug, is recommended; note, however, that desloratadine and its active metabolite 3-hydroxydesloratadine cannot be eliminated by hemodialysis.
In animal studies, lethality was observed at or above doses of 250 mg/kg in rats and of 353 mg/kg in mice (oral LD50), doses that represent 120 and 290 times the human exposure based on the recommended daily oral dose. In monkey, no deaths occurred at doses up to 250 mg/kg, representing an exposure roughly 810 times that of the recommended dose in humans.
Precaution
Hepatic and renal impairment. Pregnancy and lactation.
Interaction
Concomitant administration of Erythromycin, Ketoconazole, Azithromycin, Fluoxetine, and Cimetidine with Neo Loridin increased the plasma concentration of Neo Loridin. But there were no clinically relevant changes in the safety profile of Neo Loridin.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
Neo Loridin Disease Interaction
Elimination Route
Neo Loridin administered orally for ten days to healthy volunteers as a 5 mg tablet once daily resulted in a mean Tmax of approximately 3 hours, a mean steady-state Cmax of 4 ng/ml, and a mean steady-state AUC of 56.9 ng*hr/ml. A similar profile was observed using 10 ml of an oral solution containing 5 mg of desloratadine. Food was found not to affect desloratadine absorption.
Half Life
Neo Loridin has a mean plasma elimination half-life of approximately 27 hours.
Elimination Route
Approximately 87% of a C-desloratadine dose was equally recovered in urine and feces as metabolic products.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Neo Loridin should be used in pregnancy only if clearly needed.
Lactation: Neo Loridin passes into breast milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue Neo Loridin, taking into account the importance of the drug to the mother.
Contraindication
Neo Loridin is contraindicated in patient having hypersensitivity to this medication or to any of its ingredients or Loratadine.
Special Warning
Paediatric Use: The safety and effectiveness of Neo Loridin in pediatric patients under 2 years of age have not been established.
Geriatric Use: In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
In adult patients with liver or renal impairment: A starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.
Acute Overdose
No clinically relevant adverse events have been reported in case of overdosage. However, in the event of overdosage, symptomatic and supportive treatment is recommended.
Storage Condition
Store in a cool and dry place, protected from light.
Innovators Monograph
You find simplified version here Neo Loridin
Neo Loridin contains Desloratadine see full prescribing information from innovator Neo Loridin Monograph, Neo Loridin MSDS, Neo Loridin FDA label
FAQ
What is Neo Loridin used for?
Neo Loridin is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. Neo Loridin is used to treat allergies. It is an active metabolite of loratadine. It is used to relieve the symptoms of hay fever and hives of the skin.
How safe is Neo Loridin?
Neo Loridin is a safe and effective treatment for allergic diseases.
How does Neo Loridin work?
Neo Loridin works by blocking histamine, a substance in the body that causes allergic symptoms.
What are the common side effects of Neo Loridin?
Common side effects of Neo Loridin are include:
- headache.
- nausea.
- diarrhea.
- dizziness.
- sore throat.
- dry mouth.
- muscle pain.
- extreme tiredness
Is Neo Loridin safe during pregnancy?
As such these findings provide reassurance by indicating that the fetal safety of Neo Loridin is similar to the currently recommended antihistamines during pregnancy and thus Neo Loridin can be considered to be another option for use during pregnancy.
Is Neo Loridin safe during breastfeeding?
Considering the minimal exposure of a nursing infant to the drugs through breast milk, maternal use of Neo Loridin dose is unlikely to result in adverse effects in nursing infants and is considered to be compatible with breastfeeding.
Can I drink alcohol with Neo Loridin?
Neo Loridin alone or in combination with alcohol was safe and well tolerated.
Can I drive after taking Neo Loridin?
Do not drive and do not use tools or machines.
When should be taken of Neo Loridin?
You can take Neo Loridin before or after meals.
Can I take Neo Loridin every day?
The recommended dose of Neo Loridin tablets is one 5 mg tablet once daily.
How long does Neo Loridin take to work?
Neo Loridin is also use to relieve the symptoms of allergic skin conditions such as skin itch and hives. Neo Loridin usually starts to work within 75 minutes and lasts for 24 hours.
What is the half-life of Neo Loridin ?
The 27-hour half-life of Neo Loridin permits once daily administration.
How long can I take Neo Loridin for?
You can limit treatment to 14 days.
Can I take Neo Loridin for a long time?
Neo Loridin is unlikely to do you any harm if you take it for a long time. However, it's best to take it only for as long as you need to. It's best not to drink alcohol while you're taking Neo Loridin, as it can make you feel sleepy.
Who should not take Neo Loridin?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happen if I overdose of Neo Loridin?
tiredness. sleepiness. menstrual pain. Increased sleepiness or tiredness can happen if you take more Neo Loridin than your doctor prescribed to you.
Can Neo Loridin cause infertility?
Neo Loridin is not expected to cause other pregnancy problems.
Does Neo Loridin increase blood pressure?
The decongestant in Neo Loridin and pseudoephedrine may cause blood pressure to increase and may also speed up the heart rate.
Can Neo Loridin affects my kidney?
Older patients are more likely to have kidney or liver problems which may make them more sensitive to the effects of Neo Loridin. Your doctor may give you a different Neo Loridin dose if you have kidney or liver problems.
