Neofungina

Neofungina Uses, Dosage, Side Effects, Food Interaction and all others data.

Undecylenate, or undecylenic acid, is an unsaturated fatty acid with a terminal double bond that is derived from castor oil. Neofungina is also found naturally in the human sweat. It is used as a precursor in the manufacture of aromatic chemicals, polymers or modified silicones . Neofungina was first isolated from the products of distillation of castor oil in 1877 via pyrolysis of ricinoleic acid, and has been polymerized for vinyl production . It it suggested that many organic fatty acids exert fungicidal or fungistatic actions. Neofungina also possesses antifungal properties, but is never used on its own for antifungal purposes. Salts of undecylenate are found in topical over-the-counter or mixture products as antifungal agents. Zinc undecylenate is an example of a topical antifungal agent that treats skin infections such as athlete’s foot and relieves itching, burning, and irritation associated with the skin condition. Due to its bifunctional properties, undecylenate is also used as a linking molecule to conjugate other biomolecules such as proteins. It serves as an acid moiety for anabolic steroid boldenone.

Zinc undecylendate acts as a fungistatic agent but fungicidal activity may be observed with chronic exposure in high concentrations . It is effective against Candida albicans . It is proposed that undecylenic acid exerts antimicrobial actions via interacting with nonspecific components in the cell membrane .

Trade Name Neofungina
Generic Undecylenic acid
Undecylenic acid Other Names 10-undecenoic acid, ácido 10-undecenoico, Undecenoic acid, Undecylenate, Undecylenic acid
Type
Formula C11H20O2
Weight Average: 184.2753
Monoisotopic: 184.146329884
Protein binding

No information regarding protein binding.

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Colombia
Last Updated: September 19, 2023 at 7:00 am
Neofungina
Neofungina

Uses

Neofungina is an antifungal used to treat tinea species infections.

Indicated for the treatment of fungal infections as a salt form. No therapeutic indications on its own.

Neofungina is also used to associated treatment for these conditions: Ringworm, Tinea Pedis

How Neofungina works

Neofungina demonstrated effectiveness against Candida albicans, which is an opportunistic pathogenic yeast with two cellular morphologies: the round yeast form and the filamentous form with elongated hyphae. Hyphae formation is associated with active infections and virulence . A study proposed that undecylenic acid inhibits biofilm formation of Candida albicans with optimal concentration above 3 mM and disrupts hyphal growth, which is the morphological transition from yeast to filamentous phase, at concentration above 4 mM . Under the drug treatment, hyphal formation related genes, like HWP1, were significantly reduced in transcriptional level leading to poor biofilm formation . Both biofilm and hyphae formation are critical virulence factors for the initiation of skin infection and late development of disseminated infection . Neofungina may also inhibit enzyme involved in lipid metabolism and abolish germ tube formation by carrying protons across the plasma membrane, thus altering cytoplasmic pH .

Toxicity

Acute oral LD50 in rat and mouse are 2500 mg/kg and 8150 mg/kg, respectively . Acute dermal LD50 in guinea pig and rat are 50 mg/kg and 2000 mg/kg, respectively . There are no data available on the carcinogenicity, mutagenicity, teratogenicity and developmental toxicity of undecylenate .

Oral overdosage may lead to gastrointestinal disturbances, and may affect central nervous system (excitement, somnolence, muscle contraction or spasticity, headache, dizziness), and metabolism (loss of appetite). Prolonged or repeated exposure to undecylenate may cause anorexia or weight loss .

Food Interaction

No interactions found.

Volume of Distribution

No information regarding volume of distribution.

Elimination Route

Neofungina may be absorbed through the skin .

Half Life

No information regarding half-life.

Clearance

No information regarding clearance.

Elimination Route

No information regarding route of elimination.

Innovators Monograph

You find simplified version here Neofungina

*** Taking medicines without doctor's advice can cause long-term problems.
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