Neropin

Neropin Uses, Dosage, Side Effects, Food Interaction and all others data.

Neropin is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Neropin is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.

Neropin acts as a direct antagonist at muscarinic acetylcholine receptors in cholinergically innervated organs. Its anticholinergic-parasympatholytic action reduces the tonus of smooth muscle in the bladder, effectively reducing the number of required voids, urge incontinence episodes, urge severity and improving retention, facilitating increased volume per void.

Trade Name Neropin
Availability Prescription only
Generic Flavoxate
Flavoxate Other Names Flavoxate, Flavoxato, Flavoxatum
Related Drugs oxybutynin, Myrbetriq, phenazopyridine, Pyridium, solifenacin, tolterodine, mirabegron, Ditropan, Detrol, VESIcare
Type
Formula C24H25NO4
Weight Average: 391.4596
Monoisotopic: 391.178358293
Groups Approved
Therapeutic Class BPH/ Urinary retention/ Urinary incontinence
Manufacturer
Available Country Taiwan
Last Updated: September 19, 2023 at 7:00 am
Neropin
Neropin

Uses

Neropin is used for symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis and urethrocystitis.

Neropin is also used to associated treatment for these conditions: Cystitis, Dysuria, Kidney Stones, Menstrual Distress (Dysmenorrhea), Neurogenic Bladder Dysfunction, Nocturia, Pelvic Floor Dysfunctions, Pelvic Pain, Prostatitis, Suprapubic pain, Urethritis, Urethrotrigonitis, Urinary Incontinence (UI), Urinary Tract Infection, Urinary Urgency, Uterine dyskinesia, Cystalgia, Urethrocystitis

How Neropin works

Neropin acts as a direct antagonist at muscarinic acetylcholine receptors in cholinergically innervated organs. Its anticholinergic-parasympatholytic action reduces the tonus of smooth muscle in the bladder, effectively reducing the number of required voids, urge incontinence episodes, urge severity and improving retention, facilitating increased volume per void.

Dosage

Neropin dosage

Adults and children over 12 years of age: 100 mg to 200 mg 3 times a day. With improvement of symptoms, the dose may be reduced.

Pediatric Use: Safety and effectiveness in children below the age of 12 years have not been established.

Side Effects

Gastrointestinal: Nausea, vomiting, dry mouth.

CNS: Vertigo, headache, mental confusion, especially in the elderly, drowsiness, nervousness.

Hematologic: Leukopenia (which is reversible upon discontinuation of the drug).

Cardiovascular: Tachycardia and palpitation.

Allergic: Urticaria and other dermatoses, eosinophilia and hyperpyrexia.

Ophthalmic: Increased ocular tension, blurred vision, disturbance in eye accommodation.

Toxicity

The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.

Precaution

Neropin should be given cautiously in patients with suspected glaucoma

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

Well absorbed from gastrointestinal tract.

Elimination Route

57% of the flavoxate HCl was excreted in the urine within 24 hours.

Pregnancy & Breastfeeding use

Pregnancy: Pregnancy Category B. This drug should be used during pregnancy only if clearly needed.

Nursing Mothers: It is not known whether this drug is excreted in human milk. Caution should be exercised when flavoxate is administered to a nursing woman.

Contraindication

Neropin is contraindicated in patients who have any of the following obstructive conditions: pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, achalasia, gastrointestinal hemorrhage and obstructive uropathies of the lower urinary tract.

Storage Condition

Store Neropin at room temperature, between 20 and 25 degrees C

Innovators Monograph

You find simplified version here Neropin

Neropin contains Flavoxate see full prescribing information from innovator Neropin Monograph, Neropin MSDS, Neropin FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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