Nervegates Gold
Nervegates Gold Uses, Dosage, Side Effects, Food Interaction and all others data.
Astaxanthin acts as an antioxidant by dual mode of action. It suppresses singlet oxygen and also inhibits lipid peroxidation. By these actions it reduces the harmful free radicals. Therefore acts as a very strong antioxidant. Astaxanthin is absorbed by passive diffusion into the intestinal epithelium alongside fatty acids. Then it is incorporated into lipoproteins, transported to the liver, via lymph and blood and partly resecreted with lipoproteins. More than 70% of the Astaxanthin is contained in high-density lipoprotein part of plasma. Highest concentration of Astaxanthin is in the small intestine, followed by subcutaneous fat, spleen, liver, heart, kidney and skin and lowest in the muscles.
Evening primrose oil comes from the extraction from Oenothera biennis seeds and it is commonly used as an alternative source for omega-6 essential fatty acids. In its composition it presents some fatty acids such as Linolenic acid and Gamolenic acid. Evening primrose oil has been filled for the FDA by Humanetics Corporation on April 2000 to be a new dietary ingredient but its current status is "Inadequate basis for expectation of safety". By Health Canada, evening primrose oil is approved in over-the-counter combination dietary supplements. By the EMA, evening primrose oil is approved in herbal preparations.
The effectivity of evening primrose oil is debatable as the evidence is very limited. Evening primrose oil improves the essential fatty acid content in plasma, erythrocyte, and platelet lipids. It has also been registered to increase alpha-tocopherol levels in non-diabetic and type I diabetic patients. Evening primrose oil affects the fatty acid composition of serum lipids and adipose tissue as well as it helps maintain normal cellular structures and it serves as a prostaglandin precursor. Administration of evening primrose oil is part of long-term therapy and thus, immediate results are never expected.
Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
| Trade Name | Nervegates Gold |
| Generic | Vitamin A / Retinol + Mecobalamin + Astaxanthin + Green Tea + Vitamin E / Tocopherol + Evening Primrose Oil |
| Weight | 5000iu |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | Gates Byby Pharmaceuticals |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Astaxanthin is used to-
1. Strong antioxidant
2. Improves cardiovascular health (Atherosclerosis, reduce cholesterol).
3. Improves immune function.
4. Improves condition of skin
5. Protects skin from damage caused by sun (Reduce wrinkles, pimples and other signs of aging)
6. Improves recovery from central nervous system injuries
7. Protects from Parkinson ’s disease, Dementia and Alzheimer\'s
8. Protects eyes from cataracts and macular degeneration.
9. Reduces inflammation (Arthritis)
10. Reduces risk of infertility
Also Astaxnthin effectively reduce oxidative damage to DNA, decrease the risk for many types of cancer and stabilize blood sugar.
Evening primrose oil is used as part of over-the-counter dietary supplements.
It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical mastalgia. These indications do not have sufficient evidence of their effectiveness. It was used for the treatment of atopic dermatitis in the United Kingdom but it is currently withdrawn due to lack of evidence of effectiveness.
Mecobalamin is used for-
- Peripheral Neuropathies
- Diabetic Neuropathy
- Verteberal Syndrome
- Nerve Compression Syndrome
- Multiple sclerosis
- Amyotrophic lateral sclerosis
- Parkinson’s disease
- Alzheimer’s disease
- Diabetic retinopathy
- Entrapment neuropathy
- Drug induced neuropathy
- Megaloblastic anemia due to Vitamin B12 deficiency
Nervegates Gold is also used to associated treatment for these conditions: Dietary supplementationVitamin B12 Deficiency, Nutritional supplementation
How Nervegates Gold works
Evening primrose oil presents a content of 74% Linolenic acid and 9% Gamolenic acid from which the later seems to be the key active ingredient of this oil. These major essential fatty acids are required for the normal structure of cell membranes and they are not synthesized endogenously. The therapeutic activity of evening primrose oil is attributed to the direct action of its essential fatty acids on immune cells as well as to an indirect effect on the synthesis of eicosanoids. The actions of highly unsaturated fatty acids in tissues and eicosanoids are thought to be implicated in inflammatory and immunologic pathogeneses.
The essential fatty acids found in evening primrose oil are involved in the biosynthesis of prostaglandin. For this activity, the main involved component is the Gamolenic acid. The presence of this essential fatty acid allows the synthesis of anti-inflammatory substances such as 15-hydroxy-eicosatrienoic acid and prostaglandin E1.
Dosage
Nervegates Gold dosage
Adults (18 years and older) - Daily dose is 4mg. should be taken along with or immediately prior to meals in the morning.
Different dose for various use are given below:
4 mg: Used as a strong antioxidant, improves cardiovascular health (Atherosclerosis, reduce cholesterol), improves immune function.
4-8 mg: Improves condition of skin, protects skin from sun damage (Reduce wrinkles, pimples and other signs of aging), improves recovery from central nervous system injuries and protects eyes from cataracts and macular degeneration.
8-12 mg: Reduces inflammation (Arthritis)
16 mg: Reduces risk of infertility
Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.
Injection:
- Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
- Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy
Side Effects
No severe side effects have been reported yet
Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.
Toxicity
Evening primrose oil seems to have little toxicological effect in humans. The reported LD50 values in the mouse are 3.12 x 10^4 mcg/kg. The toxicological effects are very minimal and it has proven to not have an effect on tumor incidence nor to present effects on fertility studies.
Precaution
Pregnant women and nursing mothers should avoid Astaxanthin containing supplements.
The medicine should not be used for months if there is no response at all after its use for a certain period of time.
Interaction
Concomitant intake of Astaxanthin with Cholestyramine, Colestipol, Mineral oil, Orlistat may reduce the absorption rate of Astaxanthin
Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
Volume of Distribution
No pharmacokinetic data available.
Elimination Route
The pharmacokinetics of evening primrose oil is mainly studied by analyzing its active ingredient Gamolenic acid. After administration, Gamolenic acid is rapidly absorbed and converted directly to Dihomo-gamma-linolenic acid and other precursors. When orally administered, the tmax was directly dependent to the time of administration, being of 2.7 hours in the evening and 4.4 hours in the morning. The Cmax and AUC were registered to be approximately 21 mcg/ml and 274 mcg.h/ml. The bioavailability of Gamolenic acid acid is influenced by triglyceride composition, cellular kinetics of phospholipases and acyltransferases.
Half Life
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
Elimination Route
The major components of the primrose oil are highly metabolized and the majority of the generated metabolites are excreted in the urine.
Pregnancy & Breastfeeding use
Both pregnant women and lactating mothers should avoid Astaxanthin supplements as no data on safety has been found yet
Not recommended during pregnancy & lactation.
Contraindication
Contraindicated for those with known allergies to Astaxanthin
Hypersensitivity to any component of this product.
Special Warning
Use in children: Not recommended.
Acute Overdose
No case of overdose has occurred with Astaxanthin
Storage Condition
Store in cool and dry place, away from direct light. Keep out of reach of children.
Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Innovators Monograph
You find simplified version here Nervegates Gold
