Nevola 50 mg Tablet (Extended Release)
Nevola 50 mg Tablet (Extended Release) Uses, Dosage, Side Effects, Food Interaction and all others data.
Nevola 50 mg Tablet (Extended Release) is the principal active metabolite of venlafaxine. The exact mechanism is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the CNS, through inhibition of their reuptake.
Nevola 50 mg Tablet (Extended Release) is a selective serotonin and norepinephrine reuptake inhibitor. It lacks significant activity on muscarinic-cholinergic, H1-histaminergic, or α1-adrenergic receptors in vitro. Nevola 50 mg Tablet (Extended Release) does not appear to exert activity against calcium, chloride, potassium and sodium ion channels and also lacks monoamine oxidase (MAO) inhibitory activity. It was also shown to lack significant activity again the cardiac potassium channel, hERG, in vitro. Compared to other SNRIs, desvenlafaxine undergoes simple metabolism, has a low risk of drug-drug interactions and does not have to be extensively titrated to reach a therapeutic dose.
Trade Name | Nevola 50 mg Tablet (Extended Release) |
Availability | Prescription only |
Generic | Desvenlafaxine |
Desvenlafaxine Other Names | Desvenlafaxina, Desvenlafaxine |
Related Drugs | Rexulti, sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta, Prozac |
Weight | 50 mg |
Type | Tablet (Extended Release) |
Formula | C16H25NO2 |
Weight | Average: 263.3752 Monoisotopic: 263.188529049 |
Protein binding | Protein binding is 30% and this is independent of drug concentration. |
Groups | Approved, Investigational |
Therapeutic Class | Serotonin-norepinephrine reuptake inhibitor (SNRI) |
Manufacturer | Ziska Pharmaceuticals Ltd. |
Available Country | Bangladesh |
Last Updated: | September 24, 2024 at 5:38 am |
Uses
Nevola 50 mg Tablet (Extended Release), a serotonin and norepinephrine reuptake inhibitor (SNRI), is used for the treatment of major depressive disorder (MDD). The efficacy of Nevola 50 mg Tablet (Extended Release) has been established in four short-term (8-week, placebo-controlled studies) and two maintenance studies in adult outpatients who met DSM-IV criteria for major depressive disorder.
Nevola 50 mg Tablet (Extended Release) is also used to associated treatment for these conditions: Hot Flushes, Major Depressive Disorder (MDD)
How Nevola 50 mg Tablet (Extended Release) works
Nevola 50 mg Tablet (Extended Release), the active metabolite of venlafaxine, is a selective serotonin and norepinephrine reuptake inhibitor. Nevola 50 mg Tablet (Extended Release) inhibits neurotransmitter reuptake in serotonin, norepinephrine, and dopamine transporters. Nevola 50 mg Tablet (Extended Release) inhibits serotonin transporters with 10 times the affinity of norepinephrine transporters, and dopamine transporters with the lowest affinity. In vitro, desvenlafaxine has no inhibition of monoamine oxidase, and almost no affinity for muscarinic, cholinergic, H1-histaminergic, and alpha1-adrenergic receptors.
Dosage
Nevola 50 mg Tablet (Extended Release) dosage
The recommended dose for Nevola 50 mg Tablet (Extended Release)is 50 mg once daily, with or without food. The 50 mg dose is both a starting dose and the therapeutic dose. Nevola 50 mg Tablet (Extended Release) should be taken at approximately the same time each day. Tablets must be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.In clinical studies, doses of 10 mg to 400 mg per day were studied.
In clinical studies, doses of 50 mg to 400 mg per day were shown to be effective, although no additional benefit was demonstrated at doses greater than 50 mg per day and adverse reactions and discontinuations were more frequent at higher doses.
The 25 mg per day dose is intended for a gradual reduction in dose when discontinuing treatment. When discontinuing therapy, gradual dose reduction is recommended whenever possible to minimize discontinuation symptoms
Side Effects
Suicidal thinking/ behaviour, HTN, mydriasis, seizure, hyponatraemia, interstitial lung disease and eosinophilic pneumonia; nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence, decreased appetite, anxiety, sexual function disorders in males (e.g. anorgasmia, decreased libido, abnormal orgasm, delayed ejaculation, erectile dysfunction, ejaculation disorder, ejaculation failure, sexual dysfunction).
Toxicity
Nevola 50 mg Tablet (Extended Release) is excreted in breast milk and as a result, nursing mothers must either stop the drug or stop breast feeding depending on the risks and benefit to mother and child.
Precaution
Patient with pre-existing HTN or other conditions that may be compromised by increased BP, raised intraocular pressure, personal or family history of mania or hypomania; CV, cerebrovascular or lipid metabolism disorders; seizure disorder. Avoid abrupt withdrawal. Renal and moderate to severe hepatic impairment. Pregnancy and lactation.
Interaction
Increased risk of bleeding with aspirin or other NSAIDs, warfarin and other anticoagulants.
Food Interaction
- Avoid alcohol.
- Avoid St. John's Wort.
- Take with or without food. The absorption is unaffected by food.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Nevola 50 mg Tablet (Extended Release) Hypertension interaction
[Moderate] Selective serotonin and norepinephrine reuptake inhibitor antidepressants (SNRIs) have been associated with sustained increases in blood pressure.
Therapy with SNRI antidepressants should be administered cautiously in patients with preexisting hypertension.
Blood pressure should be assessed prior to initiating treatment and monitored regularly.
The dose should be reduced or discontinued if necessary.
Nevola 50 mg Tablet (Extended Release) Drug Interaction
Major: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, duloxetine, escitalopram, lithium, lisdexamfetamine, bupropion, sertralineModerate: aripiprazole, lamotrigine, lurasidone, pregabalin, quetiapine, alprazolam, cetirizineUnknown: omega-3 polyunsaturated fatty acids, metoprolol, cyanocobalamin, ascorbic acid, cholecalciferol
Nevola 50 mg Tablet (Extended Release) Disease Interaction
Major: depression, renal diseaseModerate: glaucoma, hypertension, hyponatremia, mania, seizures, urinary tract obstruction
Volume of Distribution
3.4L/kg.
Elimination Route
Oral bioavailability is approximately 80% and is unaffected by food. Peak plasma concentration is reached in 7.5 hours.
Half Life
The mean terminal half life is 11.1 hours and may be prolonged in patients with renal and/or moderate to severe hepatic impairment.
Elimination Route
Nevola 50 mg Tablet (Extended Release) is mainly excreted in the urine. 45% of the dose is unchanged in the urine, 19% is excreted as a glucuronide metabolite, and 4. No dosage adjustment is necessary for gender, ethnicity, food, or combination with other psychotropics.
Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Contraindication
Concurrent use or within 14 days of discontinuing MAOIs (e.g. linezolid, IV methylene blue). Initiation of MAOI at least 7 days after discontinuing desvenlafaxine.
Special Warning
Hepatic impairment (Moderate to severe): 50 mg daily. Max: 100 mg once daily.
Renal Impairment:
- CrCl <30 or ESRD: 25 mg daily or 50 mg every other day. Supplemental doses should not be given after dialysis.
- CrCl (30-50): Max 50 mg once daily.
Storage Condition
Store between 20-25° C.
Innovators Monograph
You find simplified version here Nevola 50 mg Tablet (Extended Release)
Nevola 50 mg Tablet (Extended Release) contains Desvenlafaxine see full prescribing information from innovator Nevola 50 mg Tablet (Extended Release) Monograph, Nevola 50 mg Tablet (Extended Release) MSDS, Nevola 50 mg Tablet (Extended Release) FDA label
FAQ
What is Nevola 50 mg Tablet (Extended Release) used for?
Nevola 50 mg Tablet (Extended Release) is used to treat depression. Nevola 50 mg Tablet (Extended Release) is in a class of medications called selective serotonin and Nevola 50 mg Tablet (Extended Release) is a medication used to treat depression. It is recommended that the need for further treatment be occasionally reassessed.
How safe is Nevola 50 mg Tablet (Extended Release)?
Safety results indicate that Nevola 50 mg Tablet (Extended Release) treatment is generally safe and well tolerated.
How does Nevola 50 mg Tablet (Extended Release) work?
Nevola 50 mg Tablet (Extended Release) works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance.
What are the common side effects of Nevola 50 mg Tablet (Extended Release)?
Common side effects of Nevola 50 mg Tablet (Extended Release) are include:
Drowsiness, dizziness, nausea, dry mouth, constipation, loss of appetite, weight loss, blurred vision, nervousness, trouble sleeping, or excessive sweating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Is Nevola 50 mg Tablet (Extended Release) safe during pregnancy?
Nevola 50 mg Tablet (Extended Release) should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. A pregnancy exposure registry is available.
Is Nevola 50 mg Tablet (Extended Release) safe during breastfeeding?
Modest doses of Nevola 50 mg Tablet (Extended Release) are excreted into breastmilk, but serum drug levels of breastfed infants are less than 10% of simultaneous maternal levels. Total Nevola 50 mg Tablet (Extended Release) exposure of breastfed infants is about half of that experienced by breastfed infants whose mothers are taking Nevola 50 mg Tablet (Extended Release).
Can I drink alcohol with Nevola 50 mg Tablet (Extended Release)?
You should avoid or limit the use of alcohol while being treated with Nevola 50 mg Tablet (Extended Release).
Can I drive after taking Nevola 50 mg Tablet (Extended Release) ?
You should avoid driving a car or operating machinery.
When is the best time to take Nevola 50 mg Tablet (Extended Release)?
Nevola 50 mg Tablet (Extended Release) is usually taken once a day with or without food. Take Nevola 50 mg Tablet (Extended Release) at around the same time every day.
How long does Nevola 50 mg Tablet (Extended Release) take to work ?
Nevola 50 mg Tablet (Extended Release) may show some improvement within the first 1-2 weeks.
Can I take Nevola 50 mg Tablet (Extended Release) for a long time?
There are no known problems associated with long term use of Nevola 50 mg Tablet (Extended Release). It is a safe and effective medication when used as directed.
How long can I take Nevola 50 mg Tablet (Extended Release)?
Clinical guidelines for depression treatment recommend that you keep taking your antidepressant for 4 to 9 months after your depression symptoms improve.
Who should not take Nevola 50 mg Tablet (Extended Release)?
You should not use Nevola 50 mg Tablet (Extended Release) if you are allergic to Nevola 50 mg Tablet (Extended Release). Do not use Nevola 50 mg Tablet (Extended Release) within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Can I overdose on Nevola 50 mg Tablet (Extended Release) ?
Nevola 50 mg Tablet (Extended Release) can cause delayed onset seizures. There is also a risk of serotonin toxicity in overdose. There are active metabolites, so symptoms can be prolonged.
Does Nevola 50 mg Tablet (Extended Release) affect fertility?
While Nevola 50 mg Tablet (Extended Release) may or may not affect fertility for the woman, it is important to note that antidepressants typically reduce sex drive.
Does Nevola 50 mg Tablet (Extended Release) cause high blood pressure?
Nevola 50 mg Tablet (Extended Release) may increase blood pressure. Your blood pressure should be checked regularly while you are taking this medication.
Is Nevola 50 mg Tablet (Extended Release) good for anxiety?
Nevola 50 mg Tablet (Extended Release) is not FDA approved to treat anxiety.
Can Nevola 50 mg Tablet (Extended Release) affect my kidneys?
Any medication, if taken without consultation with your physician, can cause kidney damage.