New Galto Plus
New Galto Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme that is found in species of papaya, Carica papaya and Vasconcellea cundinamarcensis. The enzyme is found to be localized in the skin of papaya, and is collected from slashed unripe papayas as a crude latex. Papain is used in food, pharmaceutical, textile, and cosmetic industries. While it has been used for the treatment of inflammation and pain via topical administration, papain has also shown to have anthelmintic and tooth-whitening properties. Present in over-the-counter mixture products consisting of different digestive enzymes, its active site contains a catalytic diad that plays a role in breaking peptide bonds. Papain is also used as an ingredient in various enzymatic debriding preparations.
Papain is a digestive enzyme and often acts as a skin allergen.
Saccharomyces cerevisiae is a fungus which can provoke allergic reactions. Saccharomyces cerevisiae is used in allergenic testing.
Lactase is an enzyme that helps to prevent symptoms of lactose intolerance by breaking down milk sugar (lactose) to produce glucose and galactose via hydrolysis and making dairy foods easier to digest.
The use of a single oral administration of tilactase has been shown to be highly effective in decreasing the symptoms and hydrogen excretion of hypolactasia in tests of lactose H(2)-breath. The analysis has shown a decrease of approximately 80% in both malabsorbers and intolerants.The administration of tilacatase also decreases the presence of bloating and flatus.
| Trade Name | New Galto Plus |
| Generic | Alpha Amylase + Papain + Alpha Galactosidase + Saccharomyces Cerevisiae + Tilactase + Glucoamylase + Invertase + Protease + Cellulase + Betaglucan |
| Weight | 170000iu |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | Ordain Health Care Global Private Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Papain is a proteolytic enzyme derived from papaya used for its anti-inflammatory properties.
No FDA-approved therapeutic indications.
Saccharomyces cerevisiae is an extract from Saccharomyces cerevisiae used in allergy testing.
Lactase is used for preventing symptoms of lactose intolerance such as bloating, flatulence, diarrhea etc.
New Galto Plus is also used to associated treatment for these conditions: InflammationLactose Intolerance
How New Galto Plus works
When topically applied, papain induces an allergen-like inflammatory response via recruiting neutrophils, mast cells, and CD3-positive cells and by induction of a TH2-biased antibody response . In vitro, treatment of papain resulted in the breakdown of tight junctions of primary human keratinocytes that maintain the epithelial barrier integrity. These tight junction proteins include zonula occludens-1, claudin-4, and occludin . It is proposed that papain induces allergic responses via activation of TLR4, leading to an increase in neutrophils, CD3+ cells, mast cells, and CCL8-positive cells .
Lactose is the primary disaccharide found in dairy products. Tilactase is a type of lactase which is the enzyme that is in charge of the breakdown of lactose to glucose and galactose which can be used by the body. Basically, tilactase acts by replacing the missing lactase in the body and allows avoidance of the reach of lactose to the small intestine and the normal bacteria and thus, preventing the symptoms of the lactose intolerance. Once tilactase has metabolized the lactose, the metabolism products are reabsorbed by the normal process of digestion.
Dosage
New Galto Plus dosage
Adult: 1 tablet (300 mg) with dairy food. If needed dose can be adjusted up to 2 tablets (600 mg) at a time.
Children: Effective & safe in children above 4 years of age.
Side Effects
There are no major side effects reported. The very few side effects may include rash, difficulty in breathing, tightness in chest etc.
Toxicity
Acute oral LD50 of 200 mcu papain is 4000 mg/kg in rat and 12500 mg/kg in mouse . It acts as an irritant in case of inhalation or contact with eyes.
Tilactase is known to present a low acute oral toxicity in preclinical trials. The lowest toxic dose for subcutaneous exposure is of 26 g/kg administered over 30 days. There have not been performed enough studies regarding the use of pregnancy or related to the fetal development. There are no reports of overdose with tilactase.
Interaction
No information for lactase interactions has been found yet.
Volume of Distribution
No pharmacokinetic data available.
Tilactase is not absorbed and thus the volume of distribution is not relevant.
Elimination Route
No pharmacokinetic data available.
Tilactase is not absorbed in the GI tract and thus the pharmacokinetic parameters related to absorption are not relevant.
Half Life
No pharmacokinetic data available.
Tilactase half-life at 35ºC is registered to be 123.77 min. This half-life can be affected by temperature in an inversely proportional manner.
Clearance
No pharmacokinetic data available.
Tilactase is not absorbed and thus the clearance rate is not relevant.
Elimination Route
No pharmacokinetic data available.
Tilactase is completely eliminated in the feces either unchanged or as metabolites.
Pregnancy & Breastfeeding use
Use in Pregnancy: It is unknown if lactase may cause harm to the fetus. Therefore, lactase should be given during pregnancy only when clearly needed.
Use in lactating mother: It is unknown if lactase is excreted in breast milk. Thus, lactase should be given during lactation only when clearly needed.
Contraindication
This drug is contraindicated in patients with known hypersensitivity to lactase or any other components of the product.
Innovators Monograph
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