Niclosamide
Niclosamide Uses, Dosage, Side Effects, Food Interaction and all others data.
Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals.
Niclosamide, once marketed in the US under the brand name Niclocide, was voluntarily withdrawn from market by Bayer in 1996.
Niclosamide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism.
| Trade Name | Niclosamide |
| Availability | Discontinued |
| Generic | Niclosamide |
| Niclosamide Other Names | Niclosamide |
| Related Drugs | praziquantel, paromomycin, Biltricide, Humatin |
| Type | Oral |
| Formula | C13H8Cl2N2O4 |
| Weight | Average: 327.12 Monoisotopic: 325.986112168 |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Niclosamide is an anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children.
For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.
Niclosamide is also used to associated treatment for these conditions: Helminthic infection, Tapeworm infestation
How Niclosamide works
Niclosamide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclosamide may work as a molluscicide by binding to and damaging DNA.
Toxicity
Infrequent, mild, and transitory adverse events include nausea, vomiting, diarrhea, and abdominal discomfort.
Elimination Route
Niclosamide appears to be minimally absorbed from the gastrointestinal tract—neither the drug nor its metabolites have been recovered from the blood or urine.
Innovators Monograph
You find simplified version here Niclosamide
