Niflumic Acid
Niflumic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
Niflumic Acid is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Niflumic Acid, a nonsteroidal anti-inflammatory fenamate, is a Ca2+-activated Cl- channel blocker.
| Trade Name | Niflumic Acid |
| Generic | Niflumic acid |
| Niflumic acid Other Names | Acide niflumique, Acido niflumico, Acidum niflumicum, Niflumic acid |
| Type | |
| Formula | C13H9F3N2O2 |
| Weight | Average: 282.218 Monoisotopic: 282.061612157 |
| Protein binding | 90% bound to plasma proteins. |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Niflumic Acid is a cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma.
Used in the treatment of rheumatoid arthritis.
Niflumic Acid is also used to associated treatment for these conditions: Inflammation, Pain, Inflammatory, Postoperative Inflammatory Response
How Niflumic Acid works
Niflumic Acid is able to inhibit both phospholipase A2 as well as COX-2, thereby acting as an antiinflamatory and pain reduction agent.
Toxicity
Oral, mouse: LD50 = 350 mg/kg; Oral, rat: LD50 = 250 mg/kg
Elimination Route
Well absorbed following oral administration.
Half Life
2.5 hours
Innovators Monograph
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