Nilutamidum

Nilutamidum Uses, Dosage, Side Effects, Food Interaction and all others data.

Nilutamidum is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamidum is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamidum blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.

Nilutamidum is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamidum is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamidum blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration. The relative binding affinity of nilutamide at the androgen receptor is less than that of bicalutamide, but similar to that of hydroxuflutamide.

The relative binding affinity of nilutamide at the androgen receptor is less than that of bicalutamide, but similar to that of hydroxuflutamide.

Table Of contents

• Nilutamidum
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Nilutamidum
Availability	Prescription only
Generic	Nilutamide
Nilutamide Other Names	Nilutamida, Nilutamide, Nilutamidum
Related Drugs	estradiol, Premarin, Xtandi, Casodex, Zytiga, Lynparza
Type
Formula	C12H10F3N3O4
Weight	Average: 317.2207 Monoisotopic: 317.062340438
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Nilutamidum is an antineoplastic hormone used to treat prostate cancer.

For use in combination with surgical castration for the treatment of metastatic prostate cancer involving distant lymph nodes, bone, or visceral organs (Stage D2).

Nilutamidum is also used to associated treatment for these conditions: Metastatic Hormone Refractory Prostate Cancer

How Nilutamidum works

Nilutamidum competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. This blockade of androgen receptors may result in growth arrest or transient tumor regression through inhibition of androgen-dependent DNA and protein synthesis.

Toxicity

Symptoms of overdose include dizziness, general discomfort, headache, nausea, and vomiting.

Food Interaction

• Avoid alcohol.
• Take separate from meals. Take before breakfast.

[Moderate] GENERALLY AVOID: Alcohol intolerance has been reported in 5% to 20% of patients following administration of nilutamide in clinical studies.

Symptoms include facial flushes, malaise, and hypotension.

MANAGEMENT: Consumption of alcoholic beverages should be avoided in patients who experience alcohol intolerance with nilutamide.

Nilutamidum Drug Interaction

Moderate: doxorubicin, doxorubicinUnknown: paclitaxel protein-bound, paclitaxel protein-bound, dutasteride, dutasteride, aspirin, aspirin, bicalutamide, bicalutamide, estradiol, estradiol, rosuvastatin, rosuvastatin, leuprolide, leuprolide, apixaban, apixaban, estradiol, estradiol

Nilutamidum Disease Interaction

Major: hepatic dysfunction, interstitial pneumonitis

Elimination Route

Rapidly and completely absorbed, yielding high and persistent plasma concentrations.

Half Life

38.0-59.1 hours

Elimination Route

Nilutamidum is extensively metabolized andless than 2% of the drug is excreted unchanged in urine after 5 days. Fecal elimination is negligible, ranging from 1.4% to 7% of the dose after 4 to 5 days.

Innovators Monograph

You find simplified version here Nilutamidum