Nimujet Tube
Nimujet Tube Uses, Dosage, Side Effects, Food Interaction and all others data.
Nimujet Tube is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.
| Trade Name | Nimujet Tube |
| Generic | Nimesulide |
| Nimesulide Other Names | Nimesulida, Nimesulide, Nimesulidum |
| Type | Gel |
| Formula | C13H12N2O5S |
| Weight | Average: 308.31 Monoisotopic: 308.046692194 |
| Protein binding | >97.5% |
| Groups | Approved, Investigational, Withdrawn |
| Therapeutic Class | Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
| Manufacturer | Themis Medicare Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Nimujet Tube is used for acute pain; extra-articular disorders; osteoarthritis; post-op pain; primary dysmenorrhoea
Nimujet Tube is also used to associated treatment for these conditions: Menstrual Distress (Dysmenorrhea), Pain, Pain, Acute, NSAIDs
How Nimujet Tube works
The therapeutic effects of Nimujet Tube are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Dosage
Nimujet Tube dosage
100 mg twice daily.Should be taken with food. Take after meals.
Side Effects
Epigastric discomfort, heartburn or abdominal cramps, nausea, vomiting and diarrhoea; skin rash, pruritus, oedema, headache, dizziness, drowsiness; hypersensitivity reactions (e.g. bronchospasm, rhinitis, angioedema urticaria); GI haemorrhage/perforation; bullous/erosive stomatitis, purpura, thrombocytopenia, toxic epidermal necrolysis, haematuria, oliguria, and renal failure; increases in liver enzymes.
Toxicity
Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
Precaution
History of GI tract disease, infections, oedema, hypertension, elderly, lactation.
Interaction
Additive hepatotoxic effects with known hepatotoxins: anti-convulsants (e.g. valproic acid), anti-fungals (e.g. ketoconazole), anti-tuberculous drugs (e.g. isoniazid), tacrine, pemoline, amiodarone, methotrexate, methyldopa, amoxicillin/clavulanic acid. May decrease the oral bioavailability of furosemide and the natriuretic and diuretic response to furosemide. Increased risks of GI and hepatic adverse effects with other NSAIDs, including aspirin. May increase anti-coagulant effect of warfarin. Potentiates the action of phenytoin. May be displaced from binding sites with fenofibrate, salicylic acid, and tolbutamide. Interactions between NSAIDs and lithium, probenecid and ciclosporin, have been documented.
Elimination Route
Rapidly absorbed following oral administration.
Half Life
1.8–4.7 hours
Elimination Route
Renal (50%), fecal (29%)
Pregnancy & Breastfeeding use
Category not classified
Contraindication
Hypersensitivity; GI bleeding, active peptic ulcer disease; severe renal and heart failure; hepatic impairment or known liver disease; coagulation disorders; pregnancy; children <12 yr.
Acute Overdose
Epigastric pain, nausea, vomiting, drowsiness, lethargy, GI haemorrhage, seizures, hypertension, apnoea, coma, anaphylactic reactions and renal failure. Treatment is supportive.
Storage Condition
Protect from heat and humidity; store at <25°C.
Innovators Monograph
You find simplified version here Nimujet Tube
FAQ
What is Nimujet Tube used for?
Nimujet Tube is a medication used for pain relief and for the prevention of fever. Acute pain, pain due to menstrual cramps, backache, post-operative pain, osteoarthritis and fever are frequently prescribed.
how safe Nimujet Tube is?
It is safer to use one with a favourable benefit-harm balance, such as ibuprofen, when a non-steroidal anti-inflammatory drug is required.The drug is best avoided in known or suspected liver disease; caution is warranted while prescribing nimesulide concomitantly with other hepatotoxic drugs.
What are the common side effect of Nimujet Tube ?
Nimujet Tube is generally well tolerated, but side effects can include headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.
Is Nimujet Tube bad for liver?
Nimujet Tube must be withdrawn worldwide due to serious liver damage.Nimujet Tube exposes patients to fatal liver damage.
How quickly does Nimujet Tube work?
Nimujet Tube works rapidly with immediate onset of action when taken orally. It can effectively reduce pain or fever within 15minutes of taking the medicine.
Is Nimujet Tube safe during pregnancy?
Our study suggests that the use of Nimujet Tube in early pregnancy may result in a greater risk of having births with congenital urinary tract anomalies.
Can I take Nimujet Tube while breastfeeding?
The action of Nimujet Tube on milk production for infants or the composition of milk is currently unknown. Some studies also suggest that Nimujet Tube is unsafe for lactating women., lactating women are advised to take medical expert advice, take this drug with precautions, and avoid long-term use.
Can I take Nimujet Tube safe with alcohol?
Avoid consuming alcohol while taking Nimujet Tube as it can increase your risk of stomach problems.
Does bnrand increase blood pressure?
Our results indicate no difference between Nimujet Tube and ketoprofen effects on mean blood pressure values during antihypertensive therapy.
Can Nimujet Tube be taken empty stomach?
Do not take it on an empty stomach.Always take Nimujet Tube together with food or immediately after a meal.
Is Nimujet Tube safe for kidneys?
This observation indicates that Nimujet Tube can provoke acute renal failure as a result of an obstructive crystalline nephropathy.
Can heart patients take Nimujet Tube?
Nimujet Tube should be used with great caution in patients with compromised renal function, cirrhosis of liver, congestive heart failure, renovascular disease, volume or salt depletion.
Is Nimujet Tube good for headache?
Nimujet Tube with Paracetamol is used for pain relief.
Is Nimujet Tube used for migraine?
Nimujet Tube has a well documented efficacy for relieving symptoms associated with migraine and non-migraine headaches.
Can Nimujet Tube I take in periods?
Nimujet Tube reduces the pressure during the maximal but not during the submaximal pain period, with concomitant alleviation of pain. The drug changes the painful state of uterine contracture to painless cyclic contractions.
Can Nimujet Tube use for ear pain?
Nimujet Tube indicate that the drug may be an effective and well tolerated therapy for painful inflammatory conditions of the ear, nose and throat.
Can Nimujet Tube cause sleepiness?
Nimujet Tube suspension overdose can make you drowsy (feeling sleepy).Generally suspension does not make you feel drowsy.
Can Nimujet Tube be used for throat pain?
Nimujet Tube which may be prescribed by your doctor to get rid of a sore throat and fever if you get these symptoms.
Is Nimujet Tube safe for adults?
Nimujet Tube may safe for adult if Nimujet Tube recommended dose in 100 mg twice daily for no more than 15 days.
How bad is bnand?
Nimujet Tube must be withdrawn worldwide due to serious liver damage.It exposes patients to fatal liver damage.
Can I take Nimujet Tube for a long time?
Nimujet Tube is not recommended long-term, as for chronic conditions such as arthritis. This is due to its association with an increased risk of liver toxicity, including liver failure.
Can I drive after taking Nimujet Tube?
Nimujet Tube may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.
