ninlaro

ninlaro Uses, Dosage, Side Effects, Food Interaction and all others data.

ninlaro a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of myeloma growth and prevention of bone loss. ninlaro citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug that becomes quickly converted to its active metabolite, ixazomib, after administration.

In vitro studies have shown ixazomib to induce apoptosis in multiple myeloma cells sensitive or resistant to other conventional therapies. In mouse xenograft models, ixazomib induced tumor growth inhibition.

Trade Name ninlaro
Availability Prescription only
Generic Ixazomib
Ixazomib Other Names Ixazomib
Related Drugs Revlimid, Velcade, Darzalex, Pomalyst, Ninlaro, Kyprolis
Weight 2.3mg, 3mg, 4mg,
Type Capsule, Oral Capsule
Formula C14H19BCl2N2O4
Weight Average: 361.03
Monoisotopic: 360.081492
Protein binding

99%

Groups Approved, Investigational
Therapeutic Class
Manufacturer Takeda Pharma A,s, Takeda Uk Ltd
Available Country Saudi Arabia, Canada, United Kingdom, United States,
Last Updated: September 19, 2023 at 7:00 am
ninlaro
ninlaro

Uses

ninlaro is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already.

ninlaro is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.

ninlaro is also used to associated treatment for these conditions: Multiple Myeloma (MM)

How ninlaro works

ninlaro is an N-capped dipeptidyl leucine boronic acid which reversibly inhibits the CT-L proteolytic (β5) site of the 20S proteasome. At higher concentrations, ixazomib also seems to inhibit the proteolytic β1 and β2 subunits and to induce accumulation of ubiquitinated proteins.

Toxicity

Drug-induced liver injury, hepatocellular injury, hepatic steatosis, hepatitis cholestatic and hepatotoxicity have each been reported in <1% of patients. ninlaro can cause fetal harm when administered to pregnant women, and therefore it should also be advised to women of reproductive age to avoid becoming pregnant on ixazomib.

Food Interaction

  • Avoid St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce the serum concentration of ixazomib.
  • Take on an empty stomach. Food increases the absorption of ixazomib, take ixazomib dose at least one hour before and at least two hours after food.

[Moderate] ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of ixazomib.

A food effect study found that administration of a single 4 mg dose of ixazomib with a high-fat meal decreased ixazomib peak plasma concentration (Cmax) by 69% and systemic exposure (AUC) by 28%.

MANAGEMENT: ninlaro should be taken at least one hour before or two hours after eating.

On days when both ixazomib and dexamethasone are administered, advise patients to separate dosing times, since dexamethasone should be taken with food while ixazomib should be taken on an empty stomach.

Volume of Distribution

The steady-state volume of distribution is 543 L.

Elimination Route

After oral administration, the time to reach maximum concentration in plasma was 1 hour. The mean absolute oral bioavailability is 58%.

Half Life

Terminal half-life is 9.5 days.

Elimination Route

62% in urine and 22% in feces.

Innovators Monograph

You find simplified version here ninlaro

*** Taking medicines without doctor's advice can cause long-term problems.
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