Nithiodote
Nithiodote Uses, Dosage, Side Effects, Food Interaction and all others data.
Sodium thiosulfate acts as an antidote in the treatment of cyanide poisoning. It acts as a sulphur-donating substrate for the enzyme rhodanese, thus speeding up the conversion of cyanide to thiocyanide, which is relatively non toxic. It is often used in combination with sodium nitrite but may be used alone in less severe poisoning.
| Trade Name | Nithiodote |
| Generic | Sodium Thiosulfate |
| Weight | 30mg + 250mg/ml, |
| Type | Intravenous solution |
| Therapeutic Class | Antidote preparations |
| Manufacturer | Hope Pharmaceuticals Ltd |
| Available Country | United Kingdom, United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cyanide poisoning
Dosage
Nithiodote dosage
Adult: To be given after 300 mg of sodium nitrite has been admin over 5-20 min: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 min. Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.
Child: To be given after 4-10 mg/kg of sodium nitrite (max: 300 mg) has been admin: 400 mg/kg of sodium thiosulfate, as a 25 or 50% solution (max: 12.5 g). Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.
Side Effects
Osmotic disturbances. Oral: catharsis (at high doses).
Precaution
May irritate eyes, skin and respiratory tract.
Interaction
Decreases toxicity of cisplatin through rapid chemical inactivation of its platinum component.
Pregnancy & Breastfeeding use
Pregnancy Category- C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Contraindication
Oedematous sodium-retaining conditions.
Innovators Monograph
You find simplified version here Nithiodote
FAQ
What is Nithiodote used for?
Nithiodote used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. For cyanide poisoning it is often used after the medication sodium nitrite and typically only recommended for severe cases.
How safe is Nithiodote?
Ingestion of large amounts may cause gastrointestinal irritation.May cause respiratory tract irritation. Low hazard for usual industrial handling.
How does Nithiodote work?
Nithiodote works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.
What are the common side effects of Nithiodote?
Common side effects of Nithiodote are include:
- Agitation.
- hallucinations (seeing, hearing, or feeling things that are not there)
- mental changes.
- muscle cramps.
- nausea and vomiting.
- pain in the joints.
- ringing in the ears.
Is Nithiodote safe during pregnancy?
If Nithiodote is required in the management of cyanide poisoning during pregnancy, treatment should not be withheld on account of pregnancy.
Is Nithiodote safe during breastfeeding?
Breastfeeding is not recommended.There is no information regarding this drug on the presence in human milk, the effects on a breastfed infant, or effects on milk production.
What happens if I ingest Nithiodote?
light-headed feeling, like you might pass out, shortness of breath, tiredness; fast or irregular heart rate, pounding heartbeats or fluttering in your chest.
What does Nithiodote do to the body?
Nithiodote works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.
How quickly does Nithiodote work?
Symptomatic relief and clinical improvement may occur within 2 weeks.
Is Nithiodote good for skin?
Nithiodote is used to treat a fungal infection of the skin called tinea versicolor.
Is Nithiodote bad for my skin?
Do not put on irritated skin. If you use Nithiodote and salicylic acid too often, your skin problem may become worse. Talk with your doctor before you use other drugs or products on your skin.
Does Nithiodote lower blood pressure?
Nithiodote can causes Low blood pressure also with other side effects.
When do I administer Nithiodote?
Nithiodote may be administered soon after prior treatment with a fast-acting cyanide antidote such as Nithiodote. Blood pressure must be monitored during infusion in both adults and children. The rate of infusion should be decreased if significant hypotension is noted.
Is Nithiodote light sensitive?
None under normal processing. Chemical Stable under normal conditions. Light sensitive.
Is Nithiodote a salicylic acid?
Nithiodote is an antifungal medicine that fights infections caused by fungus. salicylic acid helps your skin absorb the sodium thiosulfate.
Is Nithiodote a chemical antidote?
Nithiodote can be used for treatment of acute cyanide poisoning in combination with sodium nitrite.
How long is Nithiodote good for?
At the time of the case report, 18 months had elapsed since the infusions were discontinued, and the patient remained free of skin lesions. Based on the lack of recurrence with extended treatment, the authors suggested that the optimal duration of Nithiodote therapy is several months.
Is Nithiodote harmful to fish?
Excess Nithiodote up to 100 parts per million will not harm fish.
How quickly does Nithiodote work?
Symptomatic relief and clinical improvement may occur within 2 weeks.
Does Nithiodote remove oxygen?
Nithiodote acts as an oxygen scavenger. Oxygen scavengers are reducing agents in that they remove dissolved oxygen from water by reducing molecular oxygen to compounds in which oxygen appears in the lower.
Can I overdose Nithiodote?
Nithiodote is used to treat cyanide poisoning. If a poisoning or overdose occurs, get emergency help. Do not treat a poisoning or overdose yourself.
Is Nithiodote toxic?
btrand is an agent with a low order of toxicity.
Who should not take Nithiodote?
Do not take this medication if you are allergic to Nithiodote or any ingredients contained in this drug.
