Nitrendipine Ohara

Nitrendipine Ohara Uses, Dosage, Side Effects, Food Interaction and all others data.

Nitrendipine Ohara is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.

Nitrendipine Ohara, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine Ohara is similar to other peripheral vasodilators. Nitrendipine Ohara inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Nitrendipine Ohara
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
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Interaction With other Medicine
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Trade Name	Nitrendipine Ohara
Generic	Nitrendipine
Nitrendipine Other Names	Nitrendipine, Nitrendipino, Nitrendipinum
Type
Formula	C₁₈H₂₀N₂O₆
Weight	Average: 360.3612 Monoisotopic: 360.132136382
Protein binding	> 99%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Japan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Nitrendipine Ohara is a dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension.

For the treatment of mild to moderate hypertension

Nitrendipine Ohara is also used to associated treatment for these conditions: High Blood Pressure (Hypertension)

How Nitrendipine Ohara works

By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine Ohara inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.