Nitrendipine Ohara

Nitrendipine Ohara Uses, Dosage, Side Effects, Food Interaction and all others data.

Nitrendipine Ohara is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.

Nitrendipine Ohara, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine Ohara is similar to other peripheral vasodilators. Nitrendipine Ohara inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Trade Name Nitrendipine Ohara
Generic Nitrendipine
Nitrendipine Other Names Nitrendipine, Nitrendipino, Nitrendipinum
Type
Formula C18H20N2O6
Weight Average: 360.3612
Monoisotopic: 360.132136382
Protein binding

> 99%

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Japan
Last Updated: September 19, 2023 at 7:00 am
Nitrendipine Ohara
Nitrendipine Ohara

Uses

Nitrendipine Ohara is a dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension.

For the treatment of mild to moderate hypertension

Nitrendipine Ohara is also used to associated treatment for these conditions: High Blood Pressure (Hypertension)

How Nitrendipine Ohara works

By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine Ohara inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Food Interaction

  • Take with or without food.

Innovators Monograph

You find simplified version here Nitrendipine Ohara

*** Taking medicines without doctor's advice can cause long-term problems.
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