Nitrosol Topical Spray 400 mcg/spray
Nitrosol Topical Spray 400 mcg/spray Uses, Dosage, Side Effects, Food Interaction and all others data.
| Trade Name | Nitrosol Topical Spray 400 mcg/spray |
| Generic | Nitroglycerin (Sublingual Spray) |
| Weight | 400 mcg/spray |
| Type | Topical Spray |
| Therapeutic Class | Nitrates: Coronary vasodilators |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
Nitroglycerin sublingual spray is indicated for acute relief of an attack or prophylaxis of angina pectoris due to coronary artery disease.Dosage
Nitrosol Topical Spray 400 mcg/spray dosage
At the onset of an attack, 1 or 2 metered sprays should be administered under the tongue. No more than 3 metered sprays are recommended within a 15 minute period. If the chest pain persists, prompt medical attention is recommended. Nitroglycerin spray may be used prophylactically 5 to 10 minutes prior to engaging in activities which might precipitate an acute attack. Special Instructions: In the case of angina patients, it is important to carry Nitroglycerin Spray all times (We recommend keeping a second supply at home on a bedside table or wherever it can be reached easily). This drug is not for routine use. It is only to be used at the onset of chest pain. Do not drink alcoholic beverages after taking this medication. Do not take sildenafil, vardenafil or tadalafil while using any nitroglycerin product. Using these drugs together can result in a severe lowering of blood pressure, loss of consciousness, heart attack or death. Keep in a safe place away from children. How to use Nitroglycerin spray: Sit down if possible as soon as you feel an attack of angina coming on. Remove the plastic cap, do not shake the container. Hold the container upright with forefinger on top of the button. Open the mouth and bring the container as close to it as possible, aiming it under the tongue. Press the button slowly on the top of the container to spray under the tongue. Release button and close mouth. Avoid swallowing immediately after administering the spray. Do not take water to mouth within 5-10 minutes after administering the spray. If you require a second administration to obtain relief, repeat steps 3, 4, 5 & 6. Put the plastic cap in position.Side Effects
A number of nitrate related adverse effects may occur including headache, facial flushing, dizziness, nausea, vomiting, feelings of weakness, postural hypotension and reflex tachycardia .Precaution
The use of Nitroglycerin during the early days of acute myocardial infarction requires particular attention to monitoring hemodynamics and clinical status. Nitroglycerin should be used with caution in patients with severely impaired renal or hepatic function, hypothyroidism, malnutrition or hypothermia.Interaction
Use of alcohol with Nitroglycerin may produce severe hypotension and collapse. Oral Nitroglycerin may enhance the bioavailability of dihydroergotamine. Orthostatic hypotension may occur with the combined use of calcium channel blocker, phenothiazines and tricyclic antidepressants.Pregnancy & Breastfeeding use
Pregnancy Category C. There are no adequate and well controlled studies in pregnant women. Nitroglycerin should be given to pregnant women only if clearly needed. It is not known whether nitroglycerin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Nitroglycerin spray is administered to a nursing woman.Contraindication
Hypersensitivity to nitrates or any constituents of the formulation. Hypotension, hypovolaemia, severe anaemia, cerebral haemorrhage and brain trauma, mitral stenosis and angina caused by hypertrophic obstructive cardiomyopathy. Concomitant administration of phosphodiesterase inhibitors used for the treatment of erectile dysfunction.Special Warning
Safety and effectiveness of nitroglycerin in pediatric patients have not been established.Acute Overdose
Nitrate overdosage may result in: severe hypotension, persistent throbbing headache, vertigo, palpitation, visual disturbance, flushing and perspiring skin (later becoming cold and cyanotic), nausea and vomiting (possibly with colic and even bloody diarrhea), syncope (especially in the upright posture), methemoglobinemia with cyanosis and anorexia, initial hyperpnea, dyspnea and slow breathing, slow pulse, heart block, increased intracranial pressure with cerebral symptoms of confusion and moderate fever, paralysis and coma followed by clonic convulsions and possibly death due to circulatory collapse.Methemoglobinemia: Case reports of clinically significant methemoglobinemia are rare at conventional doses of organic nitrates. The formation of methemoglobin is dose-related and in the case of genetic abnormalities of hemoglobin that favor methemoglobin formation, even conventional doses of organic nitrates could produce harmful concentrations of methemoglobin.Treatment of Overdosage: Keep the patient recumbent in a shock position and comfortably warm. Passive movement of the extremities may aid venous return. Administer oxygen and artificial ventilation, if necessary. If methemoglobinemia is present, administration of methylene blue (1% solution), 1-2 mg per kilogram of body weight intravenously, may be required. If an excessive quantity of Nitroglycerin spray has been recently swallowed, gastric lavage may be of use.Storage Condition
Store in a cool and dry place away from light and heat. Keep all medicines out of the reach of children.Innovators Monograph
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