Nix Dermal
Nix Dermal Uses, Dosage, Side Effects, Food Interaction and all others data.
Nix Dermal induces electrochemical abnormalities across the membranes of excitable cells, leading to sensory hyperexcitability, in coordination and prostration. Nix Dermal is rapidly metabolized in mammals by ester hydrolysis to inactive metabolites which are excreted primarily in the urine. The principal metabolites of Nix Dermal are detectable in the urine within hours of a whole body application of the cream to healthy volunteers or scabies patients. The highest levels of excretion are detectable within the first 48 hours, but very low levels of metabolites are still detectable in the urine of some individuals 28 days after treatment.
Nix Dermal, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.
| Trade Name | Nix Dermal |
| Generic | Permethrin |
| Permethrin Other Names | Permethrin |
| Type | |
| Formula | C21H20Cl2O3 |
| Weight | Average: 391.288 Monoisotopic: 390.07894992 |
| Groups | Approved, Investigational |
| Therapeutic Class | Parasiticidal preparations |
| Manufacturer | |
| Available Country | Canada, United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Nix Dermal is used for the treatment of scabies.
Nix Dermal is also used to associated treatment for these conditions: Head Lice Infestation, Norwegian scabies, Scabies, Lice of the pubic area
How Nix Dermal works
Nix Dermal acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance.
Dosage
Nix Dermal dosage
For 15 gm Tube:
- Adults and children (over 12 years): Use two full tube
- Children aged 6-12 years: Use a full tube
- Children aged 1-5 years: Use up to 1/2 of a tube
- Children aged 2 months to 1 year: Use up to 1/4 of a tube
For 30 gm Tube:
- Adults and children (over 12 years): Use a full tube
- Children aged 6-12 years: Use up to 1/2 of a tube
- Children aged 1-5 years: Use up to 1/4 of a tube
- Children aged 2 months to 1 year: Use up to 1/8 of a tube
- Patients of >2 months of age can use the dermal cream.
- Cream should be applied to clean, dry skin. If the body is hot due to warm bath or any other reason, skin should be allowed to cool.
- It should be applied to the whole body excluding head.
- The whole body should be washed thoroughly 8-12 hours after treatment.
- Adults and children above 12 years will use a 30 g tube as a single dose.
- If necessary maximum two tubes (60 gm) can be used as a single dose.
- The cream should not be applied to the vicinity of mouth and areas close to the eyes.
Side Effects
In scabies patients, skin discomfort, usually described as burning, stinging or tingling occurs in a few individuals soon after the cream is applied. Other transient signs and symptoms of irritation including erythema, edema, eczema, rash and pruritus which may follow the treatment of scabies with Nix Dermal are generally considered to be the part of the natural history of scabies. In patients treated for scabies, itching may persist for up to 4 weeks post-treatment. This is generally regarded as due to an allergic reaction to the dead mites under the skin and is not necessarily indicative of a treatment failure.
Toxicity
Oral, rat LD50: 430 - 4000 mg/kg; skin, rabbit LD50: 2000 mg/kg.
Precaution
Nix Dermal is not an eye-irritant, but the cream itself may cause marked irritation. Nursing staff who routinely apply Nix Dermal, may wear gloves to avoid any possible irritation to the hands.
Interaction
The treatment of eczematous-like reactions with corticosteroids should be withheld prior to treatment with Nix Dermal, as there is a risk of exacerbating the scabies infestation by reducing the immune response to the mite.
Food Interaction
No interactions found.Elimination Route
Poorly absorbed through the skin.
Elimination Route
Nix Dermal is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
Pregnancy & Breastfeeding use
There are limited data on the use of Nix Dermal in pregnancy which provide no indication of any risk to the foetus. Furthermore, the amount of Nix Dermal absorbed systemically following a whole body application is extremely low. The negative mutagenicity tests and the very low mammalian toxicity would suggest that any risk to the foetus following treatment with Nix Dermal is minimal. Inspite of these, Nix Dermal is suggested not to useduring pregnancy.
It is not known whether Nix Dermal is excreted in human breast milk. So, it should not be used in nursing mothers.
Contraindication
Nix Dermal is contraindicated in subjects with known hypersensitivity to the product, its components, other pyrethroids or pyrethrins.
Acute Overdose
There are no reports of overdosage with Nix Dermal. It is possible that excessive application of Nix Dermal might result in localized adverse reactions or more severe skin reactions.
Storage Condition
Store at a cool and dry place. Protect from light. Do not freeze.
Innovators Monograph
You find simplified version here Nix Dermal
Nix Dermal contains Permethrin see full prescribing information from innovator Nix Dermal Monograph, Nix Dermal MSDS, Nix Dermal FDA label
FAQ
What is Nix Dermal used for?
Nix Dermal is used to treat scabies and lice. It is applied to the skin as a cream or lotion. As an insecticide, Nix Dermal can be sprayed onto clothing or mosquito nets to kill the insects that touch them.Nix Dermal topical may also be used for other purposes not listed in this medication guide.
How safe is Nix Dermal?
Nix Dermal is considered safe for topical use in adults and children over the age of two months.
How does Nix Dermal work?
Nix Dermal works by paralyzing and killing the mites and their eggs.
What are the common side effects of Nix Dermal?
- Mild and transient burning and stinging.
- Itching.
- Skin redness.
- Skin swelling.
- Skin rash.
- Numbness or tingling where the medicine was applied.
- Scabies symptoms may temporarily worsen after treatment.
Common side effects of Nix Dermal are include :
Is Nix Dermal safe during pregnancy?
Animal studies have revealed no evidence of impaired fertility or harm to the fetus. There are no controlled data in human pregnancy. Nix Dermal topical is only recommended for use during pregnancy when benefit outweighs risk.
Is Nix Dermal safe during breastfeeding?
Nix Dermal is generally considered safe for children and adults of all ages, including women who are breastfeeding.
Can I drink alcohol with Nix Dermal?
After using Nix Dermal, you should wash all clothing, sheets, and towels you used in hot water. You should also clean all showers, toilets, and bathtubs with rubbing alcohol to kill remaining parasites.
Does alcohol affect Nix Dermal?
After using Nix Dermal, you should wash all clothing, sheets, and towels you used in hot water. You should also clean all showers, toilets, and bathtubs with rubbing alcohol to kill remaining parasites.
How long does it take Nix Dermal to work?
The dermal cream should be applied for 8-12 hours, while users are instructed to apply the cream rinse for 10 minutes only. Ten minutes is not long enough to enable the Nix Dermal to penetrate burrows or skin, a factor that was relevant in one case reported here.
How long does Nix Dermal last?
At the concentration level delivered in the aerosol, non-aerosol pump sprays and soak systems, an application lasts for six weeks and through six washings. Nix Dermal breaks down through exposure to air and sunlight.
Does Nix Dermal stop itching?
Even if Nix Dermal kills all the scabies, the dead mites can still make you itch for up to 4 weeks after treatment. Ask your doctor about other medications that may be used to soothe the itching.
How often can I take Nix Dermal?
Use two applications of Nix Dermal cream, seven days apart. Your whole body must be treated with the cream. Leave each application on for 8-12 hours, then wash the cream off with soap and water.
Can I overdose on Nix Dermal ?
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
Who should not take Nix Dermal?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose?
Since Nix Dermal topical is usually needed only once, you are not likely to be on a dosing schedule. Wait at least 7 days before using a second application.
Do I put Nix Dermal on vagina?
Apply Nix Dermal topical to all pubic hair and any surrounding hairs on the thighs and around the anus. Leave the medicine on for 10 minutes. Then work into a lather and rinse thoroughly with warm water.
Is it safe to use Nix Dermal everyday?
Topical Nix Dermal, applied once daily, is considered as the most effective treatment in scabies.
