NKG2D CAR-NK Cell

NKG2D CAR-NK Cell Uses, Dosage, Side Effects, Food Interaction and all others data.

These cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF. Chimeric antigen receptors (CARs) are artificial receptors consisting of an antibody-derived antigen binding domain and transmembrane and signaling domains from T-cell receptor signalling moieties. First used with autologous human T cells (CAR-T) as cancer immunotherapies, these receptors are now being engineered onto natural killer (NK) cells due to lower potential for graft-versus-host disease and cytokine release syndrome. The IL-15 superagonist increases the activity of NK cells and improves their target cytotoxicity. The GM-CSF acts as a neutralizer for the CAR-T cell-mediated cytokine release and neurotoxicity. The transmembrane NKG2D and intracellular 2B4 domains are required for optimal NK signalling and subsequent cell-mediated cytotoxicity. The ACE2 is a receptor for SARS-Cov-2, binding to the S-protein of the viral envelope and competitively inhibiting SARS-Cov-2 infection of type II alveolar epithelial cells.

Trade Name NKG2D CAR-NK Cell
Generic NKG2D-ACE2 CAR-NK Cell
NKG2D-ACE2 CAR-NK Cell Other Names ACE2 CAR-Natural Killer Cell, ACE2 CAR-NK Cell, NKG2D CAR-Natural Killer Cell, NKG2D CAR-NK Cell, NKG2D-ACE2 CAR-Natural Killer Cell
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
NKG2D CAR-NK Cell
NKG2D CAR-NK Cell

How NKG2D CAR-NK Cell works

NK cells modified by CARs play a role in targeted immunotherapy without subsequent cytokine release syndrome or neurotoxicity as these effects are mediated through GM-CSF neutralization. The NKG2D-ACE2 CAR-NK cells secreting super IL15 superagonist and GM-CSF neutralizing scFv is thought to act synergistically to target and kill cells infected with SARS-Cov-2 without widespread cytokine release and inflammation.

Innovators Monograph

You find simplified version here NKG2D CAR-NK Cell


*** Taking medicines without doctor's advice can cause long-term problems.
Share