No-ach
No-ach Uses, Dosage, Side Effects, Food Interaction and all others data.
No-ach is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.
| Trade Name | No-ach |
| Generic | Nimesulide |
| Nimesulide Other Names | Nimesulida, Nimesulide, Nimesulidum |
| Type | Tablet |
| Formula | C13H12N2O5S |
| Weight | Average: 308.31 Monoisotopic: 308.046692194 |
| Protein binding | >97.5% |
| Groups | Approved, Investigational, Withdrawn |
| Therapeutic Class | Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
| Manufacturer | Innvotek Pharmaceuticals |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
No-ach is used for acute pain; extra-articular disorders; osteoarthritis; post-op pain; primary dysmenorrhoea
No-ach is also used to associated treatment for these conditions: Menstrual Distress (Dysmenorrhea), Pain, Pain, Acute, NSAIDs
How No-ach works
The therapeutic effects of No-ach are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Dosage
No-ach dosage
100 mg twice daily.Should be taken with food. Take after meals.
Side Effects
Epigastric discomfort, heartburn or abdominal cramps, nausea, vomiting and diarrhoea; skin rash, pruritus, oedema, headache, dizziness, drowsiness; hypersensitivity reactions (e.g. bronchospasm, rhinitis, angioedema urticaria); GI haemorrhage/perforation; bullous/erosive stomatitis, purpura, thrombocytopenia, toxic epidermal necrolysis, haematuria, oliguria, and renal failure; increases in liver enzymes.
Toxicity
Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
Precaution
History of GI tract disease, infections, oedema, hypertension, elderly, lactation.
Interaction
Additive hepatotoxic effects with known hepatotoxins: anti-convulsants (e.g. valproic acid), anti-fungals (e.g. ketoconazole), anti-tuberculous drugs (e.g. isoniazid), tacrine, pemoline, amiodarone, methotrexate, methyldopa, amoxicillin/clavulanic acid. May decrease the oral bioavailability of furosemide and the natriuretic and diuretic response to furosemide. Increased risks of GI and hepatic adverse effects with other NSAIDs, including aspirin. May increase anti-coagulant effect of warfarin. Potentiates the action of phenytoin. May be displaced from binding sites with fenofibrate, salicylic acid, and tolbutamide. Interactions between NSAIDs and lithium, probenecid and ciclosporin, have been documented.
Elimination Route
Rapidly absorbed following oral administration.
Half Life
1.8–4.7 hours
Elimination Route
Renal (50%), fecal (29%)
Pregnancy & Breastfeeding use
Category not classified
Contraindication
Hypersensitivity; GI bleeding, active peptic ulcer disease; severe renal and heart failure; hepatic impairment or known liver disease; coagulation disorders; pregnancy; children <12 yr.
Acute Overdose
Epigastric pain, nausea, vomiting, drowsiness, lethargy, GI haemorrhage, seizures, hypertension, apnoea, coma, anaphylactic reactions and renal failure. Treatment is supportive.
Storage Condition
Protect from heat and humidity; store at <25°C.
Innovators Monograph
You find simplified version here No-ach
FAQ
What is No-ach used for?
No-ach is a medication used for pain relief and for the prevention of fever. Acute pain, pain due to menstrual cramps, backache, post-operative pain, osteoarthritis and fever are frequently prescribed.
how safe No-ach is?
It is safer to use one with a favourable benefit-harm balance, such as ibuprofen, when a non-steroidal anti-inflammatory drug is required.The drug is best avoided in known or suspected liver disease; caution is warranted while prescribing nimesulide concomitantly with other hepatotoxic drugs.
What are the common side effect of No-ach ?
No-ach is generally well tolerated, but side effects can include headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.
Is No-ach bad for liver?
No-ach must be withdrawn worldwide due to serious liver damage.No-ach exposes patients to fatal liver damage.
How quickly does No-ach work?
No-ach works rapidly with immediate onset of action when taken orally. It can effectively reduce pain or fever within 15minutes of taking the medicine.
Is No-ach safe during pregnancy?
Our study suggests that the use of No-ach in early pregnancy may result in a greater risk of having births with congenital urinary tract anomalies.
Can I take No-ach while breastfeeding?
The action of No-ach on milk production for infants or the composition of milk is currently unknown. Some studies also suggest that No-ach is unsafe for lactating women., lactating women are advised to take medical expert advice, take this drug with precautions, and avoid long-term use.
Can I take No-ach safe with alcohol?
Avoid consuming alcohol while taking No-ach as it can increase your risk of stomach problems.
Does bnrand increase blood pressure?
Our results indicate no difference between No-ach and ketoprofen effects on mean blood pressure values during antihypertensive therapy.
Can No-ach be taken empty stomach?
Do not take it on an empty stomach.Always take No-ach together with food or immediately after a meal.
Is No-ach safe for kidneys?
This observation indicates that No-ach can provoke acute renal failure as a result of an obstructive crystalline nephropathy.
Can heart patients take No-ach?
No-ach should be used with great caution in patients with compromised renal function, cirrhosis of liver, congestive heart failure, renovascular disease, volume or salt depletion.
Is No-ach good for headache?
No-ach with Paracetamol is used for pain relief.
Is No-ach used for migraine?
No-ach has a well documented efficacy for relieving symptoms associated with migraine and non-migraine headaches.
Can No-ach I take in periods?
No-ach reduces the pressure during the maximal but not during the submaximal pain period, with concomitant alleviation of pain. The drug changes the painful state of uterine contracture to painless cyclic contractions.
Can No-ach use for ear pain?
No-ach indicate that the drug may be an effective and well tolerated therapy for painful inflammatory conditions of the ear, nose and throat.
Can No-ach cause sleepiness?
No-ach suspension overdose can make you drowsy (feeling sleepy).Generally suspension does not make you feel drowsy.
Can No-ach be used for throat pain?
No-ach which may be prescribed by your doctor to get rid of a sore throat and fever if you get these symptoms.
Is No-ach safe for adults?
No-ach may safe for adult if No-ach recommended dose in 100 mg twice daily for no more than 15 days.
How bad is bnand?
No-ach must be withdrawn worldwide due to serious liver damage.It exposes patients to fatal liver damage.
Can I take No-ach for a long time?
No-ach is not recommended long-term, as for chronic conditions such as arthritis. This is due to its association with an increased risk of liver toxicity, including liver failure.
Can I drive after taking No-ach?
No-ach may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.
