Noprofen

Noprofen Uses, Dosage, Side Effects, Food Interaction and all others data.

An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.

Noprofen is a propionic acid derivative with analgesic, antiinflammatory and antipyretic properties. Noprofen inhibits prostaglandin synthesis by decreasing the enzyme needed for biosynthesis. In patients with rheumatoid arthritis, the anti-inflammatory action of fenoprofen has been evidenced by relief of pain, increase in grip strength, and reductions in joint swelling, duration of morning stiffness, and disease activity (as assessed by both the investigator and the patient). In patients with osteoarthritis, the anti-inflammatory and analgesic effects of fenoprofen have been demonstrated by reduction in tenderness as a response to pressure and reductions in night pain, stiffness, swelling, and overall disease activity (as assessed by both the patient and the investigator). These effects have also been demonstrated by relief of pain with motion and at rest and increased range of motion in involved joints. In patients with rheumatoid arthritis and osteoarthritis, clinical studies have shown fenoprofen to be comparable to aspirin in controlling the aforementioned measures of disease activity, but mild gastrointestinal reactions (nausea, dyspepsia) and tinnitus occurred less frequently in patients treated with fenoprofen than in aspirin-treated patients. It is not known whether fenoprofen causes less peptic ulceration than does aspirin. In patients with pain, the analgesic action of fenoprofen has produced a reduction in pain intensity, an increase in pain relief, improvement in total analgesia scores, and a sustained analgesic effect.

Trade Name Noprofen
Availability Prescription only
Generic Fenoprofen
Fenoprofen Other Names Fenoprofen, Fénoprofène, Fenoprofeno, Fenoprofenum
Related Drugs Humira, Buprenex, aspirin, prednisone, ibuprofen, acetaminophen, tramadol, meloxicam, naproxen, Tylenol
Type
Formula C15H14O3
Weight Average: 242.2699
Monoisotopic: 242.094294314
Protein binding

99% to albumin.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Noprofen
Noprofen

Uses

Noprofen is an anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis.

For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain.

Noprofen is also used to associated treatment for these conditions: Mild pain, Osteoarthritis (OA), Rheumatoid Arthritis, Moderate Pain

How Noprofen works

Noprofen's exact mode of action is unknown, but it is thought that prostaglandin synthetase inhibition is involved. Noprofen has been shown to inhibit prostaglandin synthetase isolated from bovine seminal vesicles.

Toxicity

Symptoms of overdose appear within several hours and generally involve the gastrointestinal and central nervous systems. They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion. Hyperpyrexia, tachycardia, hypotension, and acute renal failure may occur rarely following overdose. Respiratory depression and metabolic acidosis have also been reported following overdose with certain NSAIDs.

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Noprofen Alcohol interaction

[Moderate] GENERALLY AVOID:

The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss.

The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.



Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

Noprofen Hypertension interaction

[Major] Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure.

Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.

Hypertension interaction

[Moderate] Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events.

NSAIDs should be used with caution in patients with hypertension.

Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.

Elimination Route

Rapidly absorbed under fasting conditions, and peak plasma levels of 50 µg/mL are achieved within 2 hours after oral administration of 600 mg doses.

Half Life

Plasma half-life is approximately 3 hours.

Innovators Monograph

You find simplified version here Noprofen

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http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5004
http://www.hmdb.ca/metabolites/HMDB0014713
http://www.genome.jp/dbget-bin/www_bget?drug:D00968
http://www.genome.jp/dbget-bin/www_bget?cpd:C06997
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3342
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504597
https://www.chemspider.com/Chemical-Structure.3225.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54705
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=4331
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=5004
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1297
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000619
http://www.pharmgkb.org/drug/PA449597
http://www.rxlist.com/cgi/generic2/fenoprofen.htm
https://www.drugs.com/cdi/fenoprofen.html
https://en.wikipedia.org/wiki/Fenoprofen
*** Taking medicines without doctor's advice can cause long-term problems.
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