Norebox

Norebox Uses, Dosage, Side Effects, Food Interaction and all others data.

Norebox is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Norebox has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.

Norebox is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class. Norebox is an a-ariloxybenzyl derivative of morpholine. Norebox is primarily used to treat depression but has also been found useful in the treatment of narcolepsy and panic disorders.

Trade Name Norebox
Generic Reboxetine
Reboxetine Other Names Reboxetina, Reboxetine
Type
Formula C19H23NO3
Weight Average: 313.397
Monoisotopic: 313.167793605
Protein binding

98%

Groups Approved, Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Norebox
Norebox

Uses

Norebox is a drug used for the acute treatment of major depression and for maintenance therapy of depression.

For the treatment of clinical depression.

Norebox is also used to associated treatment for these conditions: Major Depressive Disorder (MDD), Maintenance

How Norebox works

Norebox is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine. Norebox does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.

Toxicity

Reports of seizures (rare) have been reported

Elimination Route

Norebox is rapidly and extensively absorbed following oral administration.

Half Life

12.5 hours

Innovators Monograph

You find simplified version here Norebox

*** Taking medicines without doctor's advice can cause long-term problems.
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