Norebox Uses, Dosage, Side Effects and more
Norebox is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Norebox has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.
Norebox is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class. Norebox is an a-ariloxybenzyl derivative of morpholine. Norebox is primarily used to treat depression but has also been found useful in the treatment of narcolepsy and panic disorders.
| Attribute | Details |
|---|---|
| Trade Name | Norebox |
| Generic | Reboxetine |
| Reboxetine Other Names | Reboxetina, Reboxetine |
| Type | |
| Formula | C19H23NO3 |
| Weight | Average: 313.397 Monoisotopic: 313.167793605 |
| Protein binding | 98% |
| Groups | Approved, Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Norebox is a drug used for the acute treatment of major depression and for maintenance therapy of depression.
For the treatment of clinical depression.
Norebox is also used to associated treatment for these conditions: Major Depressive Disorder (MDD), Maintenance
How Norebox works
Norebox is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine. Norebox does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.
Toxicity
Reports of seizures (rare) have been reported
Elimination Route
Norebox is rapidly and extensively absorbed following oral administration.
Half Life
12.5 hours
