Norelgestromin

Norelgestromin Uses, Dosage, Side Effects, Food Interaction and all others data.

Norelgestromin is a drug used in contraception. Norelgestromin is the active progestin responsible for the progestational activity that occurs in women after application of ORTHO EVRA patch.

Norelgestromin is used for contraception and menopausal hormonal therapy transdermally or in combination with ethinyl estradiol as a vaginal ring. Norelgestromin, in combination with ethinyl estradiol inhibits ovulation by suppressing gonadotropins.

Norelgestromin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Norelgestromin
Generic	Norelgestromin
Norelgestromin Other Names	17-Deacetylnorgestimate, 17-Deacylnorgestimate, D-Norgestrel 3-oxime, Deacetylnorgestimate, Levonorgestrel 3-oxime, Levonorgestrel oxime, Norelgestromin, Norelgestromina, Norplant 3-oxime
Type
Formula	C₂₁H₂₉NO₂
Weight	Average: 327.468 Monoisotopic: 327.219829178
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Norelgestromin is a progestin used for the prevention of pregnancy in women who elect to use a transdermal patch as a method of contraception.

Norelgestromin is used for contraception and menopausal hormonal therapy. Norelgestromin may potentially be used in breast cancer treatment due to its inhibitory effect on estrone sulfatase . They convert sulfated steroid precursors to estrogen during pregnancy.

Norelgestromin is also used to associated treatment for these conditions: Polycystic Ovarian Syndrome, Transdermal contraception therapy

How Norelgestromin works

Norelgestromin inhibits estrone sulfatase, which converts sulfated steroid precursors to estrogen during pregnancy. Norgelgestromin/ethinylestradiol suppresses follicular development, induces changes to the endometrium, which decreases chances of implantation and thickens the cervical mucus, impeding sperm swimming into the uterus. It also has similar agonisting binding affinities as its parent compound, Norgestimate, for progesterone and estrogen receptors.