Norip

Norip Uses, Dosage, Side Effects, Food Interaction and all others data.

Norip, a dibenzocycloheptadiene tricyclic antidepressant, is the primary active metabolite of amitriptyline. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.

Norip exerts antidepressant effects likely by inhibiting the reuptake of serotonin and norepinephrine at neuronal cell membranes. It also exerts antimuscarinic effects through its actions on the acetylcholine receptor.

Trade Name Norip
Availability Prescription only
Generic Nortriptyline
Nortriptyline Other Names Demethylamitriptyline, Desmethylamitriptyline, Nortriptylina, Nortriptyline, Nortriptylinum
Related Drugs Rexulti, sertraline, trazodone, Lexapro, amitriptyline, venlafaxine, Zoloft, citalopram, Cymbalta, Effexor XR
Type Tablet
Formula C19H21N
Weight Average: 263.3767
Monoisotopic: 263.167399677
Protein binding

The plasma protein binding of nortriptyline is approximately 93%.

Groups Approved
Therapeutic Class Tricyclic & related anti-depressant drugs, Tricyclic Anti-depressant
Manufacturer Tripada Healthcare Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Norip
Norip

Uses

Norip is used for the treatment of depression and nocturnal enuresis.

Norip is also used to associated treatment for these conditions: Irritable Bowel Syndrome (IBS), Major Depressive Disorder (MDD), Myofascial Pain Syndrome, Orofacial Pain, Pain, Chronic, Post-Herpetic Neuralgia (PHN)

How Norip works

Though prescribing information does not identify a specific mechanism of action for nortriptyline, is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at the level of the beta-adrenergic receptors. It displays a more selective reuptake inhibition for noradrenaline, which may explain increased symptom improvement after nortriptyline therapy. Tricyclic antidepressants do not inhibit monoamine oxidase nor do they affect dopamine reuptake. As with other tricyclics, nortriptyline displays affinity for other receptors including mACh receptors, histamine receptors, 5-HT receptors, in addition to other receptors.

Dosage

Norip dosage

Depression:

  • Adult: Low dose initially increased as necessary to 75-100 mg daily in divided doses or as a single dose (max. 150 mg daily)
  • Adolescent & Elderly: 30-50 mg daily in divided doses; Child not recommended for depression

Nocturnal enuresis:

  • Child 7 years: 10 mg
  • 8-11 years: 10-20 mg
  • Over 11 years: 25-35 mg, 30 minutes before bedtime; max period of treatment (including gradual withdrawal) 3 months- full physical examination and ECG before further course.

Side Effects

The most common side effects include dry mouth, sedation, constipation and increased appetite, mild blurred vision, tinnitus, often euphoria and mania. An occasional side effect is a rapid or irregular heartbeat. Alcohol may exacerbate some of its side effects and should be avoided.

Toxicity

The oral LD50 of nortriptyline in the rat is 405 mg/kg.Symptoms of overdose with nortriptyline include cardiac arrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, coma, and CNS depression. Changes in the electrocardiogram, particularly in QRS segment, may be indicative of tricyclic antidepressant toxicity.

Precaution

Not intended for treatment of bipolar depression. Avoid abrupt withdrawal. Patient at risk of seizures, with DM, narrow angle glaucoma, urinary retention, prostatic hyperplasia, chronic constipation, history of CV disease. Renal and hepatic impairment. Elderly, childn. Pregnancy and lactation.

Interaction

Norip should not be given with adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, phenylpropanolamine, drugs that are metabolized by CYP4502D6, MAOIs, guanethidine, debrisoquine, bethanidine, clonidine and reserpine etc. Barbiturates may increase the rate of metabolism of nortriptyline.

Food Interaction

  • Avoid alcohol.
  • Take with or without food. Food decreases gastrointestinal irritation.

Norip Alcohol interaction

[Moderate] GENERALLY AVOID:

Concomitant use of ethanol and a tricyclic antidepressant (TCA) may result altered TCA plasma levels and efficacy, and additive impairment of motor skills, especially driving skills.

Acute ethanol ingestion may inhibit TCA metabolism, while chronic ingestion of large amounts of ethanol may induce hepatic TCA metabolism.

Patients should be advised to avoid alcohol during TCA therapy.

Alcoholics who have undergone detoxification should be monitored for decreased TCA efficacy.

Dosage adjustments may be required.

Volume of Distribution

The apparent volume of distribution (Vd)β, estimated after intravenous administration is 1633 ± 268 L within the range of 1460 to 2030 (21 ± 4 L/kg). Norip crosses the placenta and is found in the breast milk. It distributes to the heart, lungs, brain, and the liver.

Elimination Route

Norip is readily absorbed in the gastrointestinal tract with extensive variation in plasma levels, depending on the patient. This drug undergoes first-pass metabolism and its plasma concentrations are attained within 7 to 8.5 hours after oral administration. The bioavailability of nortriptyline varies considerably and ranges from 45 to 85%.

Half Life

The average plasma half-life of nortriptyline in healthy volunteers is about 26 hours, but is said to range from 16 to 38 hours. One study mentions a mean half-life of about 39 hours.

Clearance

The average plasma clearance of nortriptyline in a study of healthy volunteers was 54 L/h. The average systemic clearance of nortriptyline is 30.6 ± 6.9 L / h, within the range of 18.6 to 39.6 L/hour.

Elimination Route

Norip and its metabolites are mainly excreted in the urine, where only small amounts (2%) of the total drug is recovered as unchanged parent compound. Approximately one-third of a single orally administered dose is excreted in urine within 24 hours. Small amounts are excreted in feces via biliary elimination.

Pregnancy & Breastfeeding use

The safety of nortriptyline for use in pregnancy has not been established. Norip should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Contraindication

Norip is contraindicated in patients with hypersensitivity to nortriptyline. Concomitant administration with MAOI is contraindicated. Do not use with or within 2 weeks of stopping an MAOI. Norip is contraindicated during the acute recovery period after myocardial infarction.

Acute Overdose

Symptoms: Severe hypotension, cardiac dysrhythmias, shock, CHF, pulmonary oedema, convulsions, and CNS depression, including coma; changes in ECG.

Management: Symptomatic and supportive treatment. Admin IV Na bicarbonate, benzodiazepines. Admin activated charcoal to reduce absorption. Emesis is contraindicated. Initiate cardiac monitoring and observe for signs of CNS or resp depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures.

Storage Condition

Store at 15-30° C. Protect from light and moisture.

Innovators Monograph

You find simplified version here Norip

Norip contains Nortriptyline see full prescribing information from innovator Norip Monograph, Norip MSDS, Norip FDA label

FAQ

What is Norip used for?

Norip is used to treat depression. Norip is in a group of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.

Is Norip a sleeping pill?

Your doctor prescribed Norip to help relieve your pain. Although it is often used to treat depression, it is also used for pain and to improve sleep. It has been found to be safe and effective over many years of use.

What are side effects of Norip?

Some of the side effects that can occur with use of Norip include:

  • low blood pressure
  • high blood pressure
  • confusion (mainly in seniors)
  • sleep problems
  • shakiness
  • dry mouth
  • blurry vision
  • constipation
  • skin rash
  • hives
  • itching
  • skin sensitivity to light
  • nausea
  • vomiting
  • diarrhea
  • stomach cramps
  • decreased sexual desire
  • unexpected weight loss or gain
  • sweating
  • headache

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

How does Norip works?

Norip (Nortriptyline) belongs to a class of drugs called tricyclic antidepressants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Norip works on your central nervous system to increase the level of certain chemicals in your brain. This helps relieve your depression.

What is Norip?

Norip is a prescription drug. It comes as an oral capsule and an oral solution. Norip oral capsule is available as the Norip-name drug Pamelor. It’s also available as a generic drug. Generic drugs usually cost less than the Norip-name version. In some cases, they may not be available in all strengths or forms as the Norip-name drug.

What does Norip used for?

Norip is used to treat depression. Norip may used as part of a combination therapy. This means you may need to take it with other medications.

What is Dosage of Norip for depression?

Adult dosage (ages 18–64 years)

  • Recommended dosage: 25 mg, three to four times per day or once daily; start at the low level and increase as required.
  • Maximum dosage: 150 mg per day.

Child dosage (ages 0–17 years)

  • This drug is not recommended for use in children.

Senior dosage (ages 65 years and older)

  • Recommended dosage: 30–50 mg, once per day or in divided doses; start at the low level and increase as required.
  • Maximum dosage: 150 mg per day.

Does Norip affect memory?

Performance on measures of immediate and delayed recognition memory were comparable on Norip and placebo. Discontinuation of Norip resulted in significant improvement on a subset of nine memory self-assessment items.

How long does Norip take to work?

In depression it may take between two to four weeks before Norip starts to work and you begin to feel better, so it's very important that you keep taking it, even if it doesn't seem to make much difference at first.

What should not take with Norip?

Do not use nortriptyline with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid (Zyvox®), methylene blue, phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start using nortriptyline during the 2 weeks after you stop a MAO inhibitor.

Is Norip used for nerve pain?

Norip is a tricyclic antidepressant that is occasionally used for treating neuropathic pain, and is recommended in European, UK, and USA guidelines.

What does Norip do for migraines?

Norip is a tricyclic antidepressant. This class of medications works on the central nervous system by increasing the level of serotonin in your brain. Serotonin drops when a migraine attack strikes.

Can I drink coffee while taking Norip?

Norip may irritate the stomach, and should be taken with food. It is best to avoid coffee, spicy food or alcohol.

Can I drink alcohol with Norip?

Your doctor will recommend that you do not drink alcohol while you are on Norip. This is because it increases the risk of side-effects, such as feeling sleepy.

Is Norip an anti inflammatory?

Except nortriptyline and citalopram, all tested drugs showed anti-inflammatory activity.

What happens when I stop taking Norip?

Norip is a tricyclic anti-depressant. Abrupt discontinuation (withdrawal) of tricyclic anti-depressants can cause symptoms of restlessness, anxiety, chills, muscle pain, headache, dizziness, nausea and vomiting. Symptoms can be reduced by slowly reducing the dose.

Why do I take Norip at night?

The best time to take Norip is in the evening. This has the added advantage of helping you to sleep. The other most noticeable side effect that people find is a dry mouth.

Is Norip well tolerated?

Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.

Is Norip good for sciatica?

Although sciatica is common, there are no good treatments for it. Tricyclic antidepressants, such as Norip (nortriptyline), and opioids, such as morphine, have been effective in treating other kinds of pain from nerve damage.

*** Taking medicines without doctor's advice can cause long-term problems.
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