Normapac

Normapac Uses, Dosage, Side Effects, Food Interaction and all others data.

An antipsychotic agent used in schizophrenia. [PubChem]

Normapac, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Normapac is a tranquilizer for which the exact mode of action has not been established, however, it is believed that by antagonising dopamine and serotonin receptors, there is a marked cortical inhibition which can manifest as tranquilization and suppression of aggression.

Table Of contents

• Normapac
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Normapac
Availability	Prescription only
Generic	Loxapine
Loxapine Other Names	Loxapina, Loxapine, Loxapinum, Oxilapine
Related Drugs	quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, dexmedetomidine, Loxitane, promazine, Igalmi
Weight	10mg, 25mg
Type	Tablet, Capsule, Drops
Formula	C18H18ClN3O
Weight	Average: 327.808 Monoisotopic: 327.11383992
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Normapac is a antipsychotic used for the treatment of schizophrenia.

For the management of the manifestations of psychotic disorders such as schizophrenia

Normapac is also used to associated treatment for these conditions: Acute Agitation, Schizophrenia

How Normapac works

Normapac is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Normapac has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.

Toxicity

LD₅₀=65 mg/kg (Orally in mice)

Food Interaction

• Avoid alcohol.
• Take with food. Food reduces irritation.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Normapac Drug Interaction

Moderate: aripiprazole, aripiprazole, benztropine, benztropine, duloxetine, duloxetine, venlafaxine, venlafaxine, clonazepam, clonazepam, escitalopram, escitalopram, fluoxetine, fluoxetine, quetiapine, quetiapineMinor: lorazepam, lorazepamUnknown: cholecalciferol, cholecalciferol

Normapac Disease Interaction

Major: dementia, CNS depression/coma, related psychosis, previous neuroleptic malignant syndrome (NMS), seizure disorders, acute alcohol intoxication, cardiovascular disease, CNS depression, NMS, tardive dyskinesiaModerate: seizure, cardiovascular disease, glaucoma, hyperprolactinemia/breast cancer, intestinal obstruction, neutropenia, anticholinergic effects, dehydration, hyperprolactinemia, liver disease, parkinsonism

Elimination Route

Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers

Half Life

Oral-4 hours

Elimination Route

Metabolites are excreted in the urine in the form of conjugates and in the feces unconjugated.

Innovators Monograph

You find simplified version here Normapac