Np 27
Np 27 Uses, Dosage, Side Effects, Food Interaction and all others data.
Np 27 is an antifungal which inhibits growth of dermatophytes e.g. Epidermophyton, Microsporum, trichophyton spp, and Malassezia furfur by distorting the hyphae and stopping mycelial growth. It is inactive against Candida spp or bacteria.
Np 27 is a synthetic over-the-counter anti-fungal agent.
| Trade Name | Np 27 |
| Generic | Tolnaftate |
| Tolnaftate Other Names | Tolnaftate, Tolnaftato, Tolnaftatum, Tolnaphthate |
| Weight | 1%, 1%, 1%, 1% |
| Type | Topical cream, topical powder, topical solution, topical spray |
| Formula | C19H17NOS |
| Weight | Average: 307.409 Monoisotopic: 307.103084861 |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Other Antifungal preparations |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Np 27 is used to treat skin infections such as athlete's foot, jock itch, and ringworm. It is an antifungal that works by preventing the growth of fungus.
Np 27 is also used to associated treatment for these conditions: Dermatophytosis, Pityriasis versicolor, Ringworm, Tinea Corporis, Tinea Cruris, Tinea Pedis
How Np 27 works
Np 27 is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Dosage
Np 27 dosage
Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply this medication to the affected skin, usually twice a day or as directed on the product package or by your doctor. Dosage and length of treatment depends on the type of infection being treated.
Some forms of tolnaftate (e.g., powder) need to be shaken before applying. Check your product package to see if your form of this medication needs to be shaken. Apply enough medication to cover the affected area and some of the surrounding skin. After applying this medication, wash your hands. Do not wrap, cover, or bandage the area unless directed to do so by your doctor.
Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day.
Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after starting tolnaftate. Stopping the medication too early may allow the fungus to continue to grow, which may result in a relapse of the infection.
Inform your doctor if your condition persists after 2 weeks of treatment for jock itch, after 4 weeks of treatment for athlete's foot or ringworm, or if your condition worsens at any time.
Side Effects
Irritation of the treated skin may occur. If this effect persists or worsens, notify your doctor or pharmacist promptly.
If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Toxicity
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Precaution
Before using tolnaftate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: immune system problems (e.g., organ transplant, HIV disease), diabetes.
This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Interaction
There are no known significant interactions.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Np 27 topical has not been formally assigned to a pregnancy category by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. Np 27 topical is only recommended for use during pregnancy when benefit outweighs risk. There are no data on the excretion of tolnaftate topical into human milk.
Contraindication
Hypersensitivity. Nail and scalp infections. Do not apply this medication in the eyes, nose, mouth, or vagina.
Storage Condition
Store at 15-30° C.
Innovators Monograph
You find simplified version here Np 27
Np 27 contains Tolnaftate see full prescribing information from innovator Np 27 Monograph, Np 27 MSDS, Np 27 FDA label
FAQ
What is Np 27 used for?
Np 27 is used to treat skin infections such as athlete's foot, jock itch, and ringworm. It is an antifungal that works by preventing the growth of fungus. Some forms of Np 27 may also be used to prevent athlete's foot from coming back.
How safe is Np 27?
Np 27 stops the growth of fungi that cause skin infections, including athlete's foot, jock itch, and ringworm.
How should used Np 27?
Use Np 27 on the skin only. Clean and thoroughly dry the area to be treated. Apply this medication to the affected skin, usually twice a day or as directed on the product package or by your doctor.
What are the side effects of Np 27?
common side effects are include:
- skin inflammation.
- itching.
- skin irritation.
Is Np 27 safe during pregnancy?
It is not known whether Np 27 topical will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.
Is Np 27 safe during breastfeeding?
It is not known whether Np 27 topical passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.
How long does Np 27 take to work?
Some people begin to feel relief from the burning and itching within a few days of using Np 27. Most people see improvement within a week. If you see no change at all after using Np 27 for 2 or 4 weeks contact your healthcare provider.
Does Np 27 work for nail fungus?
It does not work on fungal infections of the hair or nails and it is not as effective as other over-the- counter products such as Lotrimin or Micatin for skin.
How long can I use tolnaftate?
The burning and soreness of athlete's foot or the itching of jock itch should decrease within 2 to 3 days. Continue treatment for at least 2 weeks after symptoms disappear. A total of 4-6 weeks of treatment may be necessary.
Will Np 27 cure ringworm?
Np 27 is used to treat skin infections such as athlete's foot, jock itch, and ringworm. It is an antifungal that works by preventing the growth of fungus.
Is Np 27 safe for babies?
Np 27 should not be used on children up to 2 years of age, unless otherwise directed by your doctor.
Will Np 27 cure vaginal yeast infection?
Np 27 is available as a generic and is not expensive to buy over-the-counter. It works at treating common fungal infections of the skin.
Who should not take Np 27?
You should not use Np 27 topical if you are allergic to it.
How should I use Np 27?
Do not take by mouth.Np 27 topical is for use only on the skin. Do not use this medicine on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. If this medicine gets in your eyes, nose, mouth, rectum, or vagina, rinse with water.
What happens if I miss a dose?
Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.
