Nystat Plus
Nystat Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Chlorhexidine is an antimicrobial agent; it is active against a wide range of gram-negative and grampositive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses.Nystatin has fungistatic or fungicidal activity against variety of pathogenic and nonpathogenic yeast and fungi, including Candida albicans. Nystatin exerts its antifungal activity by binding to sterols in the fungal cell membrane. As a result of binding, the membrane is no longer able to function as a selective barrier, and potassium and other cellular constituents are lost. It is poorly absorbed from the gastrointestinal tract.
| Trade Name | Nystat Plus |
| Generic | Chlorhexidine hydrochloride + Nystatin |
| Weight | 1%+100000iu |
| Type | Tablet |
| Therapeutic Class | Chlorhexidine & Chloroxylenol preparations |
| Manufacturer | ACME Laboratories Ltd, |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
This cream is a light yellow cream for application to the skin. It is used to treat skin infections caused by either fungi and/or bacteria, such as ringworm, athlete’s foot and infected nappy rash.
Nystat Plus is also used to associated treatment for these conditions: Anal candidiasis, Candidiasis, Invasive, Intestinal Candidiasis, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Oral Candidiasis, Pruritus Ani, Pruritus Vulvae, Skin candida, Trichomonas Vaginitis, Vaginal Candidiasis, Vulvovaginal Candidiasis, Corticosteroid-responsive dermatoses, Cutaneous candidiasis
How Nystat Plus works
Nystatin is a channel-forming ionophore, meaning it exerts its therapeutic effect via formation of a membrane-spanning pore in the fungal plasma membrane. The formation of this pore results in a change in membrane permeability that allows for leakage of intracellular contents and the subsequent disruption of electrochemical gradients necessary for proper cell function. Selectivity for fungal cells over mammalian cells is due to nystatin’s greater binding affinity for ergosterol, a key sterol found in fungal cell walls, as opposed to its mammalian counterpart, cholesterol.
Dosage
Nystat Plus dosage
For application to the skin only. Apply the cream to the infected area two or three times daily. The cream should be applied for one week after your infection has healed. If the infected area has not improved within seven days of starting treatment, consult your doctor. If the condition does not improve within 14 days of starting treatment, or if a new infection appears, you should stop using Nystaform Cream and consult your doctor. An alternative treatment may be needed.
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. If you experience any of the following reactions stop using Nystaform Cream and get immediate medical help: Swelling of the face, lips, tongue or throat; a red itchy skin rash; wheezing or difficulty breathing; feeling faint and dizzy; a strange metallic taste in the mouth; collapse. You may be having an allergic reaction. If you develop a rash or your skin becomes itchy, red, dry or inflamed where you have used this medicine, stop using it and talk to your doctor or pharmacist.
Toxicity
The oral LD50 in rats is 10 g/kg. There have been no reports of serious toxic effects following overdosage of nystatin - doses in excess of five million units daily have resulted in nausea and gastrointestinal upset with no other associated effects.
Precaution
Nystaform Cream may in rare cases cause severe allergic reactions, leading to a drop in blood pressure and even to unconsciousness. Early symptoms of a severe allergic reaction may be skin rash or asthma. If you notice these symptoms, stop using Nystaform Cream and contact your doctor as soon as possible.
Nystaform Cream is for external use only and should not be used near your eyes, mouth or be swallowed. If swallowed accidentally, seek medical advice immediately. If Nystaform Cream gets in your eyes accidentally, you should rinse your eyes immediately and contact your doctor.
Volume of Distribution
Nystatin is not absorbed into the systemic circulation and thus does not undergo distribution.
Elimination Route
Systemic absorption of nystatin is minimal following oral administration, and no detectable plasma concentrations are attained following topical or vaginal administration.
Elimination Route
The majority of orally administered nystatin is eliminated unchanged in the feces.
Pregnancy & Breastfeeding use
Do not use Nystaform Cream if you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Contraindication
Nystatin cream is contraindicated in patients with a history of hypersensitivity to any of its components.
There is no known contraindication to the use of Nystatin oral.
Storage Condition
Keep this medicine out of the sight and reach of children. Do not store above 25°C. Do not use this medicine after the expiry date which is stated on the tube and on the carton after EXP. The expiry date refers the last day of that month.
Innovators Monograph
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