Oceral Crème/Puder/Spray-Lösung

Oceral Crème/Puder/Spray-Lösung Uses, Dosage, Side Effects, Food Interaction and all others data.

Cream contains the antifungal active compound Oceral Crème/Puder/Spray-Lösung Nitrate. For topical dermatological use only. Oceral Crème/Puder/Spray-Lösung Nitrate is an imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has in vitro activity against a wide range of pathogenic fungi. Oceral Crème/Puder/Spray-Lösung has been shown to be active against most strains of the following organisms both in vitro and in clinical infections at indicated body sites: Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, Malassezia furfur. Oceral Crème/Puder/Spray-Lösung exhibits satisfactory in vitro minimum inhibitory concentrations (MICs) against most strains of the following organisms: Microsporum audouini, Microsporum canis, Microsporum gypseum, Trichophyton tonsurans,Trichophyton violaceum.

Oceral Crème/Puder/Spray-Lösung is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur.

Trade Name Oceral Crème/Puder/Spray-Lösung
Generic Oxiconazole
Oxiconazole Other Names Oxiconazol, Oxiconazole, Oxiconazolum
Type
Formula C18H13Cl4N3O
Weight Average: 429.12
Monoisotopic: 426.9812729
Groups Approved
Therapeutic Class Topical Antifungal preparations
Manufacturer
Available Country Switzerland
Last Updated: September 19, 2023 at 7:00 am
Oceral Crème/Puder/Spray-Lösung
Oceral Crème/Puder/Spray-Lösung

Uses

Oceral Crème/Puder/Spray-Lösung cream is used for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum. Oceral Crème/Puder/Spray-Lösung Cream is used for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur.

Oceral Crème/Puder/Spray-Lösung is also used to associated treatment for these conditions: Fungal skin infection, Pityriasis versicolor, Tinea Corporis, Tinea Cruris, Tinea Pedis

How Oceral Crème/Puder/Spray-Lösung works

Oceral Crème/Puder/Spray-Lösung inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oceral Crème/Puder/Spray-Lösung has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oceral Crème/Puder/Spray-Lösung can increase membrane permeability to zinc, augmenting its cytotoxicity.

Dosage

Oceral Crème/Puder/Spray-Lösung dosage

Cream should be applied to affected and immediately surrounding areas once to twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. Oceral Crème/Puder/Spray-LösungCream should be applied once daily in the treatment of tinea (pityriasis) versicolor. Tinea corporis, tinea cruris, and tinea (pityriasis) versicolor should be treated for 2 weeks and tinea pedis for 1 month to reduce the possibility of recurrence.

Use Oceral Crème/Puder/Spray-Lösung cream as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth, and other mucous membranes. Oceral Crème/Puder/Spray-Lösung cream isfor external use only.

Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after 2 to 4 weeks orsooner if the condition worsens.

Inform the physician if the area of application shows signs of increased irritation, itching, burning, blistering, swelling, or oozing.

Avoid the use of occlusive dressings unless otherwise directed by the physician.

Do not use this medication for any disorder other than that for which it was prescribed

Side Effects

Pruritus, burning, irritation and allergic contact dermatitis, folliculitis, erythema, and papules, fissure, maceration, rash, stinging and nodules.

Toxicity

Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.

Precaution

Oceral Crème/Puder/Spray-Lösung cream is not for ophthalmic or intravaginal use.

Interaction

Potential drug interactions between Oceral Crème/Puder/Spray-Lösung and other drugs have not been systematically evaluated.

Food Interaction

No interactions found.

Elimination Route

Systemic absorption of oxiconazole is low.

Pregnancy & Breastfeeding use

Pregnancy category B. Because Oceral Crème/Puder/Spray-Lösung Nitrate is excreted in human milk, caution should be exercised when the drug is administered to a nursing woman.

Contraindication

Oceral Crème/Puder/Spray-Lösung cream is contraindicated in individuals who have shown previous hypersensitivity to Oceral Crème/Puder/Spray-Lösung

Storage Condition

Store in a cool and dry place,protected from light. Do not freeze.

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*** Taking medicines without doctor's advice can cause long-term problems.
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