Olonaf
Olonaf Uses, Dosage, Side Effects, Food Interaction and all others data.
A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Olonaf inhibits bacterial DNA gyrase.
Olonaf is a quinolone/fluoroquinolone antibiotic. Olonaf is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
| Trade Name | Olonaf |
| Availability | Discontinued |
| Generic | Norfloxacin |
| Norfloxacin Other Names | NFLX, Norfloxacin, Norfloxacine, Norfloxacino, Norfloxacinum |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, azithromycin, ceftriaxone, levofloxacin, Augmentin, amoxicillin / clavulanate, nitrofurantoin |
| Weight | 400mg |
| Type | Tablet |
| Formula | C16H18FN3O3 |
| Weight | Average: 319.3308 Monoisotopic: 319.133219662 |
| Protein binding | 10 and 15% (Serum protein binding) |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Zanctok Pharmaceuticals |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Olonaf is a broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine.
For the treatment of urinary tract infection
Olonaf is also used to associated treatment for these conditions: Cystitis, Gonococcal cervicitis, Infectious diarrhea, Pyelitis, Pyelonephritis, Spontaneous Bacterial Peritonitis (SBP), Traveler's Diarrhea, Urethritis gonococcal
How Olonaf works
The bactericidal action of Olonaf results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Olonaf is a broad-spectrum antibiotic agent that is shown to be effective against various Gram-positive and Gram-negative bacterial species. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomonal activity
Food Interaction
- Drink plenty of fluids.
- Limit caffeine intake.
- Take on an empty stomach.
[Moderate] ADJUST DOSING INTERVAL: Concurrent ingestion of meals, dairy products (milk, yogurt) or calcium-fortified foods (i.e., cereal, orange juice) may decrease the absorption of oral norfloxacin.
The mechanism is chelation of calcium and the quinolone, resulting in decreased bioavailability.
In the case of orange juice, inhibition of intestinal transport mechanisms (P-glycoprotein or organic anion-transporting polypeptides) by flavones may also be involved.
MANAGEMENT: Oral norfloxacin should be taken at least one hour before or two hours after a meal, milk, or other dairy products or calcium-fortified foods.
Olonaf multivitamins interaction
[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.
Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.
The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.
The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.
When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.
When coadministered with Suprep Bowel Prep (magnesium Please consult individual product labeling for specific recommendations.
Olonaf Drug Interaction
Unknown: charcoal, charcoal, multivitamin, multivitamin, acetaminophen, acetaminophen, procaine penicillin, procaine penicillin, valproic acid, valproic acid, cyanocobalamin, cyanocobalamin, pyridoxine, pyridoxine, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, phytonadione, phytonadione
Olonaf Disease Interaction
Major: colitis, CNS disorders, myasthenia gravis, peripheral neuropathy, QT interval prolongation, tendonitisModerate: crystalluria, diabetes, renal dysfunction
Elimination Route
Rapid
Half Life
3-4 hours
Elimination Route
Olonaf is eliminated through metabolism, biliary excretion, and renal excretion. It is expected to undergo both glomerular filtration and tubular secretion during renal excretion, as shown by its high renal clearance rate of approximately 275 mL/min.
Innovators Monograph
You find simplified version here Olonaf
FAQ
What is Olonaf used for?
Olonaf is an antibiotic that belongs to the class of fluoroquinolone antibiotics. It is used to treat urinary tract infections, gynecological infections, inflammation of the prostate gland, gonorrhea and bladder infection.
How safe is Olonaf?
Olonaf has been relatively safe in animals over a wide range of doses. There has been no evidence of a teratogenic effect in any of the animal species tested (rat, rabbit, mouse, monkey) at six to 50 times the human dose (400 mg twice daily).
How does Olonaf work?
Olonaf works by killing the bacteria which are the cause of the infection.
What are the common side effects of Olonaf?
Common side effects of Olonaf are include :
- nausea,
- diarrhea,
- dizziness,
- stomach cramps,
- heartburn,
- rectal pain,
- lightheadedness,
- muscle and joint aches,
Is Olonaf safe during pregnancy?
Olonaf caused some fetal defects and abnormalities, so it is advisable to avoid using this Olonaf during pregnancy.
Is Olonaf safe during breastfeeding?
Use of Olonaf is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis.
Can I drink alcohol with Olonaf?
It's generally safe to drink alcohol in moderation while taking Olonaf.
Can I drive after taking Olonaf ?
The most common side-effects are feeling sick, diarrhoea, feeling dizzy and headache. Olonaf may impair your alertness, so make sure your reactions are normal before you drive and before you use tools or machines.
When should I take Olonaf?
You should take the tablets when your stomach is empty, which means taking them one hour before any food, or waiting until two hours afterwards. This is because your body absorbs less Olonaf after a meal, which means the medicine is less effective.
Can I take Olonaf on an empty stomach?
Olonaf should be taken at least 1 hour before or 2 hours after a meal, milk, or other dairy products.
How long does Olonaf take to work?
At the respective doses, mean peak serum and plasma concentrations of 0.8, 1.5 and 2.4 μg/mL are attained approximately one hour after dosing. The presence of food and/or dairy products may decrease absorption. The effective half-life of Olonaf in serum and plasma is 3-4 hours.
How long can I take Olonaf?
Your doctor will advise you on how long to take Olonaf for (usually 3 to 7 days). Some people may need to take it for longer.
Is Olonaf safe for kidneys?
Olonaf is an antibacterial drug chiefly eliminated by the kidney and therefore useful in the treatment of urinary tract infections.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Who should not take Olonaf?
Olonaf is contraindicated in persons with a history of hypersensitivity, tendinitis, or tendon rupture associated with the use of norfloxacin or any member of the quinolone group of antimicrobial agents.
How fast does Olonaf work?
The effective half-life of Olonaf in serum and plasma is 3-4 hours. Steady-state concentrations of norfloxacin will be attained within two days of dosing.
What should if I overdose on Olonaf?
If you take too much, call your healthcare provider or get medical help immediately.
Will Olonaf affect my fertility?
Olonaf significantly decreased the number of viable fetuses, increased the number of resorbed fetuses, and induced retardation in growth of viable fetuses; some visceral and skeletal defects in these fetuses were seen and these effects were dose dependant.
Can Olonaf affects my liver?
The severity of liver injury caused by Olonaf ranges from mild and transient serum enzyme elevations to self-limited but severe hepatitis, to acute liver failure and death. Complete recovery is expected after stopping the drug and recovery is usually rapid (2 to 8 weeks).
Is Olonaf good for stomach infection?
Olonaf are used for the treatment of gastrointestinal and urinary infections. These are the combination of two antibiotics which can be prevented by fighting with the bacterial cells.
Can Olonaf cause diarrhea?
Olonaf may cause diarrhea, and in some cases it can be severe.
