Olsalazine Sodium

Olsalazine Sodium Uses, Dosage, Side Effects, Food Interaction and all others data.

Olsalazine Sodium is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. Olsalazine Sodium is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Mesalamine works as an anti-inflammatory agent in treating inflammatory diseases of the intestines.

Olsalazine Sodium is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. Olsalazine Sodium reduces the bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain. Olsalazine Sodium is thought to work like balsalazide, delivering mesalazine or 5-aminosalicylic acid past the small intestine to the large intestine to act on the site of disease.

Trade Name Olsalazine Sodium
Availability Prescription only
Generic Olsalazine
Olsalazine Other Names Olsalazine
Related Drugs Entyvio, Humira, Zeposia, Colazal, prednisone, dexamethasone, methylprednisolone, hydrocortisone, hydrocortisone topical, budesonide
Type Capsule
Formula C14H10N2O6
Weight Average: 302.239
Monoisotopic: 302.053886062
Protein binding

Olsalazine and olsalazine-S are more than 99% bound to plasma proteins. Mesalamine (5-ASA) is 74% bound to plasma proteins.

Groups Approved
Therapeutic Class
Manufacturer Atnahs Pharma UK Ltd
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Olsalazine Sodium
Olsalazine Sodium

Uses

Olsalazine Sodium is an anti-inflammatory agent used in the treatment of inflammatory bowel disease and ulcerative colitis.

For the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.

Olsalazine Sodium is also used to associated treatment for these conditions: Ulcerative Colitis

How Olsalazine Sodium works

Orally administered olsalazine is converted to mesalamine which is thought to be the therapeutically active agent in the treatment of ulcerative colitis. The mechanism of action of mesalamine (and sulfasalazine) is unknown, but appears to be topical rather than systemic. Mucosal production of arachidonic acid (AA) metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes (LTs) and hydroxyelcosatetraenoic acids (HETEs) is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin (PG) production in the colon.

Toxicity

Maximum single oral doses of 5g/kg in mice and rats and 2 g/kg in dogs were not lethal.

Food Interaction

  • Take with food.

Olsalazine Sodium Disease Interaction

Moderate: renal dysfunction

Elimination Route

After oral administration, olsalazine, has limited systemic bioavailability. 98-99% of the dose is converted to mesalamine (5-ASA) in the colon, which is absorbed slowly resulting in very high local concentrations in the colon.

Half Life

Olsalazine Sodium has an elimination half-life of 0.9 hours, however, olsalazine-S has a half-life of 7 days.

Elimination Route

Approximately 0.1% of an oral dose of olsalazine is metabolized in the liver to olsalazine-O-sulfate (olsalazine-S).The remaining 5-ASA is partially acetylated and is excreted in the feces.

Innovators Monograph

You find simplified version here Olsalazine Sodium

*** Taking medicines without doctor's advice can cause long-term problems.
Share