Onyvax 105
Onyvax 105 Uses, Dosage, Side Effects, Food Interaction and all others data.
Onyvax 105 is a human monoclonal antibody that mimics the complement regulatory protein, CD55, overexpressed by many solid tumours including osteosarcoma. Onyvax 105 induced antitumour inflammatory responses in metastatic colorectal cancer patients. Onyvax 105 may be a suitable vaccine for treatment of this disease.
| Trade Name | Onyvax 105 |
| Generic | 105AD7 |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in colorectal cancer.
How Onyvax 105 works
Onyvax 105 vaccine is a human anti-idiotype which mimics the antigen 791Tgp72. The mechanism of action of the vaccine has recently been clarified. The anti-idiotype is rapidly internalized on antigen presenting cells by Fc mediated endocytosis as both Fab and Ab complexed to alum are processed 1,000 fold less efficiently than whole Ab. Sequencing of the Ab have revealed that the CDR-H3 is hypermutated and contains HLA A1, A3 and A24, and HLA-DR1, 3 and 7 MHC binding motifs.
Onyvax 105 is an antibody-based vaccine that mimics a target (CD55) which is over-expressed in numerous cancers including those of the prostate, colon and pancreas.
Innovators Monograph
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