Oraplast

Oraplast Uses, Dosage, Side Effects, Food Interaction and all others data.

Gelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former .

As a thermoreversible hydrocolloid with a small gap between its melting and gelling temperatures, gelatin provides unique advantages over carbohydrate-based gelling agents. Gelatin is mainly produced from porcine skin, and cattle hides and bones .

Some alternative raw substances have recently garnered attention from both researchers and the industry not only because they overcome religious concerns shared by both Jews and Muslims but also because they may provide scientific advantages over gelatins from mammal origins .

Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or as acid amides. Under the FDA regulation, pectin qualifies as a GRAS (generally recognized as safe) food substance. This status allows pectin to be used with no limitations.

Pectin increases viscosity and volume of stools which helps it to be used for constipation and diarrhea. It is reported as well to present lowering effects of different body components. This effect depends on the type of pectin which indicated that this effect is related to the composition of the correspondent pectin. Nonetheless, this data is still unclear and more studies need to be performed to conclude this effect of pectin.

Oraplast
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Oraplast
Generic	Gelatin + Pectin + Sodium Carmellose
Type	Paste
Therapeutic Class
Manufacturer	Icpa Health Products Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Gelatin is used for weight loss and for treating osteoarthritis, rheumatoid arthritis, and brittle bones (osteoporosis). Some people also use it for strengthening bones, joints, and fingernails. Gelatin is also used for improving hair condition and to shorten the recovery after exercise and sports-related injury . Gelatin is used in preparations of foods, cosmetics, and medicine .

Plasma volume expander in hypovolaemic shock . Haemostatic .

Gelatin-based hydrogels are being used in drug delivery and tissue engineering because they are able to promote cell adhesion and proliferation. In addition, these hydrogels can be used as wound dressings because of their attractive fluid absorbance properties. Manufacturing technologies such as ultraviolet stereolithography and two-photon polymerization can be used to prepare structures containing photosensitive gelatin-based hydrogels .

Pectin is used in food as a gelling agent and stabilizer. As a medical drug, it has obtained a great interest in its potential use as a source of dietary fiber, lipid, cholesterol, serum glucose and insulin level lowering effect, gastric emptying delay. Some recent studies have researched the possibility of using pectin for the formation of nanoparticles as a delivery vehicle of drugs.

Oraplast is also used to associated treatment for these conditions: Hypovolaemia, Acute Normovolemic Hemodilution, Plasma Volume ReplacementBacterial diarrhoea, Diarrhea caused by Salmonella, Diarrhea caused by Shigella, Diarrhea caused by Staphylococcus, Escherichia Coli Diarrhea, Sore Throat, Mouth soreness

How Oraplast works

It works as a hemostatic by providing a physical framework within which clotting may occur .

As a volume expander, gelatin remains in the vascular space. When used in the treatment of hypovolaemia gelatin can produce a significant increase in blood volume, cardiac output, stroke volume, blood pressure, urinary output and oxygen delivery, increasing volume and pressure .

For intravascular volume expansion, the majority or gelatins produce an effect which is almost equivalent to of which are mild, although severe reactions albumin, with a duration of action of 3 to 4 hours to have been reported .

Gelatin or collagen chains suspended in solution can be covalently cross-linked to form matrices that are able to swell in the presence of aqueous solutions, forming what are called gelatin hydrogels. Hydrogels, characterized by their hydrophilicity and insolubility in water, have the capability of swelling into an equilibrium volume while maintaining their shape. The chemical cross-linkers used may be either small bifunctional molecules or polyfunctional macromolecules, for example, glutaraldehyde .

Pectin is an adsorbent that binds to bacteria, toxins and other irritants in the intestinal mucosa. Pectin is able to decrease the pH in the intestinal lumen and provides a soothing effect on the irritated mucosa.

Toxicity

LD50 Rat >3750 mg/kg .

Gelatin solutions have shown to increase the risk of anaphylaxis and may be harmful by increasing mortality, renal failure, and bleeding likely due to extravascular uptake and impairment of coagulation. .

Gelatin can cause an unpleasant taste, a sensation of abdominal heaviness, bloating, heartburn, as well as belching .

Using gelatin as a plasma expander appears to have no significant advantages over crystalloids or isotonic albumin on mortality and may have a slightly higher risk of requiring allogeneic blood transfusion in perioperative and critically ill patients.

A meta-analysis found that using gelatin as a volume expander in vivo has no significant advantages over currently used volume expanders such as isotonic albumin or crystalloids and may slightly increase the risk of requiring a blood transfusion .

Pectin is a substance determined to be safe.

Volume of Distribution

Pharmacokinetic studies have not been performed as pectin is not absorbed.

Elimination Route

The bioavailability of gelatin was indirectly studied by the determining the bioavailability of total hydroxyproline in gelatin using a pharmacokinetic method after oral ingestion in rats.

The relative and absolute bioavailability of gelatin were 74.12% and 85.97%, respectively. The amino acid profile of plasma showed that 41.91% of the digested gelatin was absorbed from the intestine in the peptide form, and there was a linear correlation between the absorbed amount of an amino acid and its content in gelatin (R(2) = 0.9566). Furthermore, 17 types of collagen peptide were purified by multi-step chromatography and identified with ultra-performance liquid chromatography-electrospray ionisation-mass spectrometry .

Pectin is not absorbed and it is not distributed in the body.