Orascab
Orascab Uses, Dosage, Side Effects, Food Interaction and all others data.
Orascab selectively binds and with high affinity to glutamate-gated chloride ion channels, which occur in invertebrate nerve and muscle cells leading to an increase in the permeability of cell membranes to chloride ions with hyperpolarization of the nerve or muscle cell and, ultimately, death of the parasite.
Orascab is a semisynthetic, anthelminitic agent. It is an avermectin which a group of pentacyclic sixteen-membered lactone (i.e. a macrocyclic lactone disaccharide) derived from the soil bacterium Streptomyces avermitilis. Avermectins are potent anti-parasitic agents. Orascab is the most common avermectin. It is a broad spectrum antiparasitic drug for oral administration. It is sometimes used to treat human onchocerciasis (river blindness). It is the mixture of 22,23-dihydro-avermectin B1a (at least 90%) and 22,23-dihydro-avermectin B1b (less than 10%).
| Trade Name | Orascab |
| Availability | Prescription only |
| Generic | Ivermectin |
| Ivermectin Other Names | Ivermectin, Ivermectina, Ivermectine, Ivermectinum |
| Related Drugs | albendazole, Albenza, Stromectol, moxidectin, Mintezol |
| Type | Tablet |
| Formula | C95H146O28 |
| Weight | Average: 1736.1589 Monoisotopic: 1735.000064088 |
| Protein binding | 93% |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Anti-helminthic |
| Manufacturer | Bioderma Solutions |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Orascab is used for the treatment of the following infections:
Strongyloidiasis of the intestinal tract. Orascab is used for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis.
This indication is based on clinical studies of both comparative and open-label designs, in which 64-100% of infected patients were cured following a single 200-mcg/kg dose of ivermectin.
Onchocerciasis: Orascab is used for the treatment of onchocerciasis due to the nematode parasite Onchocerca volvulus.
This indication is based on randomized, double-blind, placebo-controlled and comparative studies conducted in 1427 patients in onchocerciasis-endemic areas of West Africa. The comparative studies used diethylcarbamazine citrate (DEC-C).
NOTE: Orascab has no activity against adult Onchocerca volvulus parasites. The adult parasites reside in subcutaneous nodules which are infrequently palpable. Surgical excision of these nodules (nodulectomy) may be considered in the management of patients with onchocerciasis, since this procedure will eliminate the microfilariae-producing adult parasites.
Orascab is also used to associated treatment for these conditions: Acne Rosacea, Ascaris lumbricoides infection, Cutaneous larva migrans, Demodicidosis, Gnathostomiasis, Mansonella ozzardi infection, Mansonella streptocerca infection, Oesophagostomiasis, Onchocerciasis, Pediculosis Capitis, Scabies, Trichuriasis, Wuchereria bancroftii infection
How Orascab works
Orascab binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Orascab also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Orascab may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.
Dosage
Orascab dosage
Oral
Filariasis:
- Adult: Dosing regimen depends on the causative agent. Mansonella streptocerca 150 mcg/kg as a single dose; Mansonella ozzardi 200 mcg/kg as a single dose.
- Child: ≥15 kg: Dosing regimen depends on the causative agent. Mansonella streptocerca 150 mcg/kg as a single dose; Mansonella ozzardi 200 mcg/kg as a single dose.
Scabies:
- Adult: Sarcoptes scabiei 200 mcg/kg as a single dose, repeat dose in 2 wk.
- Child: ≥15 kg: Sarcoptes scabiei 200 mcg/kg as a single dose, repeat dose in 2 wk.
Onchocerciasis:
- Adult:150 mcg/kg as a single dose; retreatment may be given every 6-12 mth until adult worms die.
- Child: >5 yr and ≥15kg: 150 mcg/kg as a single dose every 6-12 mth until adult worms die.
Ascariasis:
- Adult: Ascaris lumbricoides 150-200 mcg/kg as a single dose.
- Child: ≥15 kg: Ascaris lumbricoides 150-200 mcg/kg as a single dose.
Strongyloidiasis:
- Adult: 200 mcg/kg as a single dose for 1-2 days.
- Child: >15 kg: 200 mcg/kg as a single dose for 1-2 days.
Gnathostomiasis:
- Adult: Gnathostoma spinigerum: 200 mcg/kg once daily for 2 days.
- Child: ≥15 kg: Gnathostoma spinigerum: 200 mcg/kg once daily for 2 days.
Should be taken on an empty stomach.
Side Effects
Diarrhoea, nausea, vomiting, dizziness, pruritus, urticaria, rash, arthralgia, fever, myalgia, asthenia, postural hypotension, tachycardia, oedema, lymphadenopathy, sore throat, cough, headache, somnolence, transient eosinophilia, raised liver enzyme values.
Toxicity
LD50 = 29.5 mg/kg (Mouse, oral). LD50 = 10 mg/kg (Rat, oral). Adverse effects include muscle or joint pain, dizziness, fever, headache, skin rash, fast heartbeat.
Precaution
Concurrent Loa loa infection, impaired blood-brain barrier function due to infection.
Interaction
Bioavailability may be increased by alcohol, levamisole.
Food Interaction
- Take on an empty stomach.
Orascab Alcohol interaction
[Moderate] GENERALLY AVOID:
Alcohol may increase the plasma concentrations of ivermectin.
The mechanism of interaction is unknown.
In 20 healthy, nonsmoking patients with onchocerciasis, mean plasma ivermectin concentrations at 1, 3 and 4 hours post-dose (150 mcg/kg) were approximately 34% to 40% higher in the group given the medication with 750 mL of beer (4.5% v/v alcohol) than in controls who ingested the medication with water.
There were no side effects in either study or control subjects.
However, there have been anecdotal reports of increased central nervous system adverse effects and postural hypotension in patients who combined ivermectin with alcohol.
Patients receiving ivermectin therapy should preferably avoid the consumption of alcohol to prevent any undue adverse effects of ivermectin.
Orascab Drug Interaction
Unknown: diphenhydramine, diphenhydramine, ubiquinone, ubiquinone, acetylcysteine, acetylcysteine, bioflavonoids, bioflavonoids, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, zinc sulfate, zinc sulfate, cetirizine, cetirizine
Volume of Distribution
The volume of distribution is 3 to 3.5 L/kg and it does not cross the blood-brain barrier.
Elimination Route
Moderately well absorbed. Improved absorption with high fat meal.
Half Life
16 hours (also reported at 22-28 hours)
Elimination Route
Orascab is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine.
Pregnancy & Breastfeeding use
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Contraindication
Hypersensitivity. Pregnancy and lactation. Children <15 kg body weight.
Storage Condition
Store below 30°C.
Innovators Monograph
You find simplified version here Orascab
Orascab contains Ivermectin see full prescribing information from innovator Orascab Monograph, Orascab MSDS, Orascab FDA label
FAQ
What is Orascab used for ?
Orascab is an anti-parasite medication used to treat parasitic diseases. Orascab is used to prevent and treat heartworm and acariasis, among other indications.
How safe is Orascab?
Orascab is considered safe for use in humans when used in normal doses. But it's still possible to experience side effects while taking this medication.
How to use Orascab?
Take Orascab by mouth with a full glass of water on an empty stomach at least 1 hour before a meal. Orascab is usually taken as a single dose or series of doses, or as directed by your doctor.
What are the common side effects of Orascab?
Common side effects of Orascab are include:
- tiredness
- loss of energy
- stomach pain
- loss of appetite
- nausea
- vomiting
- diarrhea
- dizziness
- sleepiness or drowsiness
- itchiness
Is Orascab safe during pregnancy?
The risk versus benefit should be considered in pregnant women heavily infected with parasites, especially during mass distribution of Orascab in endemic areas. The advantage of treatment may outweigh any potential risk to the infant.
Is Orascab safe during breastfeeding?
Orascab is excreted into human milk in low concentrations. The manufacturer recommends that treatment during nursing only occur if the risk of delayed treatment to the mother outweighs the possible risk to the infant. One review article recommends the use of ivermectin in lactating women after the infant is 7 days old.
Can I drink alcohol with Orascab?
Using alcohol with Orascab can increase the blood levels or add to the side effects of Orascab.
Can I drive after taking Orascab?
Do not drive or operate heavy machinery until you know how this medication affects you.
How does Orascab work?
Orascab work by paralysing the parasite or inactivating the parasite gut.
How long does Orascab take to work ?
Orascab should take effect within 1 to 2 hours.
Should I take Orascab morning or night?
Orascab is best taken as a single dose with a full glass of water on an empty stomach (1 hour before breakfast), unless otherwise directed by your doctor.
Does Orascab affect blood pressure?
You can also overdose on Orascab, hypotension (low blood pressure).
Is Orascab hard on the kidneys?
Orascab can cause glomerular and tubular disturbances in patients with onchocerciasis; however, these are minor and do not seem to be clinically relevant.
Does Orascab raise blood sugar?
Orascab displays antidiabetic activities by reducing blood glucose and cholesterol levels, and also by improving insulin sensitivity in an FXR-dependent manner.
Who should not take Orascab?
You will need to have a stool exam after taking Orascab to make sure the infection is gone. Some patients may need to take another dose of Orascab to treat the infection. Orascab may make you feel dizzy. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
What happens if I miss a dose?
Since Orascab is usually given in a single dose, you may not be on a dosing schedule. If you are on a schedule, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention.
How long does Orascab stay in my system?
barnd starts to leave your bloodstream after about 18 hours, but it stays in your intestines and continues to kill any worms there for 12 days.
Does cause hair loss?
A lack of these nutrients can contribute to hair loss.
Does Orascab cause blood clots?
Orascab has a minimal effect on coagulation and concern about mass treatment for this reason appears to be unjustified.
Does Orascab help anxiety?
Orascab did not induce anxiety-like behavior neither affected corticosterone levels of juvenile rats.
Can Orascab help asthma?
This is the first study to demonstrate that Orascab is an effective suppressor of inflammation and may be efficacious in the treatment of non-infectious airway inflammatory diseases such as allergic asthma.
