Orina
Orina Uses, Dosage, Side Effects, Food Interaction and all others data.
The higher strength of Orina Sodium USP-NF provides long-lasting relief from dryness by forming a soothing gel after administration of the drops on to the eyes.
In a randomized clinical study of patients with mild or moderate forms of eye dryness, ophthalmic treatment with sodium carboxymethylcellulose resulted in a diminished frequency of symptoms compared to the placebo group . Orina interacts with human corneal epithelial cells to facilitate corneal epithelial wound healing and attenuate eye irritation in a dose-dependent manner . It exhibits protective actions on the ocular surface in various applications; it mediates cytoprotective effects on the ocular surface when applied prior to contact lenses and reduces the incidence of epithelial defects during LASIK .
| Trade Name | Orina |
| Generic | Carboxymethylcellulose |
| Carboxymethylcellulose Other Names | Carbose, Carboxymethyl cellulose, Carmellose, Carmelosa, Cellulose carboxymethyl ether, Cellulose gum, Thylose |
| Weight | 100mg, |
| Type | Eye Drops, Tablet, Gel |
| Protein binding | No pharmacokinetic data available. |
| Groups | Approved, Investigational |
| Therapeutic Class | Drugs for Dry eyes |
| Manufacturer | Genesis Biotech, Shrooq Pharmaceuticals, Anikem Laboratories |
| Available Country | India, Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Orina Sodium is used as a lubricant to relieve irritation and discomfort due to dryness of the eye or due to exposure to wind or sun.
Orina is also used to associated treatment for these conditions: Dry Eyes, Ocular Irritation
How Orina works
Orina binds to the surface of corneal epithelial cells via its glucopyranose subunits binding to glucose receptors GLUT-1 . The residence time of carboxymethylcellulose bound to corneal cells is approximately 2 hours as indicated by a short-term binding assay . Binding of carboxymethylcellulose to the matrix proteins stimulated corneal epithelial cell attachment, migration, and re-epithelialization of corneal wounds .
Dosage
Orina dosage
Install 1 or 2 drops in the affected eye(s) as needed or as directed by the physician.
Side Effects
Visual disturbances, ocular discharge and eye pruritus are common adverse drug reactions were reported with Orina Sodium
Toxicity
Rat oral LD50, rabbit dermal LD50, and rat inhalation LC50 of sodium carboxymethyl cellulose are 27000 mg/kg, >2 g/kg, and >5800 mg/m^3 (4 hours), respectively .
Precaution
Concomitant ocular medication should be administered 15 minutes apart to the instillation of this eye drop.
Interaction
No information is available.
Food Interaction
No interactions found.Volume of Distribution
No pharmacokinetic data available.
Elimination Route
No pharmacokinetic data available.
Half Life
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
Elimination Route
No pharmacokinetic data available.
Pregnancy & Breastfeeding use
Use in Pregnancy: There is no data on the use of Orina Sodium 1% during pregnancy and lactation in human. Animal studies did not show harmful effects with the active ingredient Orina Sodium. Use in Lactation: Orina Sodium is not absorbed systemically; there is no known potential for excretion in human breast milk.
Pediatric use: The safety and effectiveness in pediatric patients have not been established.
Contraindication
Contraindicated in patients who are hypersensitive to any of the components of Orina Sodium.
Special Warning
Use in children: No information available.
Use in elderly patients: No information available.
Acute Overdose
Since CMC is pharmacologically inert and not expected to be absorbed systemically, systemic effects from topical overdose are not expected from the administration of Orina sodium (Cellufresh) 0.5%. Additionally, no toxic side effects are expected should accidental systemic overdose occur.
Storage Condition
Store in a cool, dry place and protect from light. Keep out of the reach of children.
Innovators Monograph
You find simplified version here Orina
Orina contains Carboxymethylcellulose see full prescribing information from innovator Orina Monograph, Orina MSDS, Orina FDA label
FAQ
What is Orina used for?
Orina is a cellulose derivative with carboxymethyl groups bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone. It is often used as its sodium salt, sodium carboxymethyl cellulose. Orina is used to relieve dry, irritated eyes. Common causes for dry eyes include wind, sun, heating/air conditioning, computer use/reading, and certain medications.
How safe is Orina?
Orina is completely safe to eat. The use of Orina as a feed additive is considered safe for the environment. The additive is considered to be efficacious in feedingstuffs for all animal species.
What are the common side effects of Orina?
Many people using Orina do not have serious side effects. But unlikely occur some serious side effects of Orina are eye pain, change in vision, continued eye redness/irritation. A very serious allergic reaction to this Orina is rare.
How does Orina work?
It work by similar to natural tears and provides temporary relief from burning and discomfort due to dryness of the eye.
Is Orina safe during pregnancy?
Over-the-counter artificial tear products that contain Orina are not considered harmful to a pregnancy.
Is Orina safe during breastfeeding?
Orina are not considered harmful to a fetus or breastfeeding baby. This eye lubricant is not likely to pass into breast milk.
When should I take Orina eye drops?
Orina is used in the treatment of dry eyes. It is used as a lubricant to relive irritation and discomfort due to dryness of the eyes or due to exposure of the eyes to wind or sun.
What happen if I overdose of Orina?
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
What happen If I missed Orina?
If you use Orina on a regular basis, use a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not use 2 doses or extra doses.
How often can I use Orina ?
Usually, drops may be used as often as needed. Ointments are usually used 1 to 2 times daily as needed. If using an ointment once a day, it may be best to use it at bedtime.
Is Orina safe to eat?
As you can see from the benefits and risks outlined above, Orina is generally considered to be a fairly safe food additive. It doesn't have any nutritional value or health benefits, but it can be a very useful additive to all kinds of products.
