Ormerdan

Ormerdan Uses, Dosage, Side Effects, Food Interaction and all others data.

Ormerdan is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.

Ormerdan is a mercurial compound with toxic side effects. It is no longer used and has been replaced with new classes of diuretic drugs.

Trade Name Ormerdan
Generic Chlormerodrin
Chlormerodrin Other Names Chlormerodrin, Chlormerodrina, Chlormerodrine, Chlormerodrinum
Type
Formula C5H11ClHgN2O2
Weight Average: 367.2
Monoisotopic: 368.021530917
Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Ormerdan
Ormerdan

Uses

Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.

How Ormerdan works

Ormerdan most likely acts by a direct renal action. Mercurial diuresis is presumed to occur through inhibition of reabsorption of water and electrolytes in the convoluted tubules, although the problem of whether the locus of action is primarily on the proximal or distal portion has not yet been settled. There is also evidence that mercurials interfere with the permeability of the membrane of tubular cells by increasing passive influx of Na+ ion, Cl- ion and water into the cells, without interfering with the active extrusion of Na+ ion. Lastly, there is some evidence that chlormerodrin inhibits succinic dehydrogenase, but the clinical significance of this binding is not known.

Toxicity

As chlormerodrin has been shown to increase the levels of mercury in the kidney to toxic levels, any symptoms of overdose will most likely correspond to symptoms experienced in exposure to mercury.

Innovators Monograph

You find simplified version here Ormerdan

*** Taking medicines without doctor's advice can cause long-term problems.
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