Oroxat Tablet 20 mg

Oroxat Tablet 20 mg Uses, Dosage, Side Effects, Food Interaction and all others data.

FibroGen completed the phase I single-dose, dose escalation studies as of July 2007. Multiple dose, dose escalation and phase II US studies are listed as ongoing.

FG-4592 represents one of several next generation PHI that has been optimized for multiple pharmacokinetic and pharmacodynamic parameters related to erythropoiesis, including selective inhibition of HIF prolyl and asparaginyl hydroxylases, potency, iron utilization, and ADME. FG-4592 represents one of several next generation HIF-PH inhibitors designed to selectively induce the expression of genes that mediate erythropoiesis for the treatment of anemia.

Oroxat Tablet 20 mg
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Oroxat Tablet 20 mg
Generic	Roxadustat
Roxadustat Other Names	Roxadustat, Roxadustatum
Weight	20 mg
Type	Tablet
Formula	C₁₉H₁₆N₂O₅
Weight	Average: 352.346 Monoisotopic: 352.105921623
Groups	Investigational
Therapeutic Class
Manufacturer	Eskayef Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

In clinical development for the treatment of anemia of chronic inflammatory disease.

How Oroxat Tablet 20 mg works

FG-4592 is an orally active second generation HIF-PH inhibitor. Preclinical studies show that FG-4592 increases production of endogenous erythropoietin (EPO), increases iron mobilization and utilization, and overcomes the suppressive effects of inflammation on red blood cell production.