Ostogen Plus

Ostogen Plus Uses, Dosage, Side Effects, Food Interaction and all others data.

Each Film coated tablet contains-

Calcium Carbonate 1500 mg equivalent to 600 mg elemental CalciumVitamin-D (as Vitamin-D3) 200 I.U. as CholecalciferolMagnesium Oxide BP 66.34 mg equivalent to 40 mg MagnesiumManganese Sulfate Monohydrate 5.54 mg equivalent to 1.8 mg ManganeseCupric Oxide 1.25 mg equivalent to 1 mg Copper,Boron Citrate 5 mg equivalent 250 mcg BoronZinc Oxide 9.34 mg equivalent to 7.5 mg ZincCalcium, magnesium and vitamin-D are the macro nutrients for bone. Calcium is used as a pharmacological agent in humans almost entirely to remedy deficiency. Adequate calcium in the blood is so vital to a wide variety of bodily functions that our internal biochemistry will not tolerate a deficiency even for short periods. Clinical evidence suggests that calcium is useful for the prevention and treatment of osteoporosis and associated fractures. Vitamin-D is also essential for healthy bones as it aids in calcium absorption from the GI tract. In addition to this it stimulates bone formation. Clinical studies show that calcium and vitamin-D has synergistic effects on bone growth as well as in osteoporosis and fracture prevention. Magnesium also increases bone strength and rigidity. Some micro nutrients like copper, manganese, zinc and boron also play important role in bone health.

CalciumCarbonate1500mgequivalentto600mgelementalCalciumVitamin-D(asVitamin-D3)200I.U.asCholecalciferolMagnesiumOxideBP66.34mgequivalentto40mgMagnesiumManganeseSulfateMonohydrate5.54mgequivalentto1.8mgManganeseCupricOxide1.25mgequivalentto1mgCopper,BoronCitrate5mgequivalent250mcgBoronZincOxide9.34mgequivalentto7.5mgZincCalcium,magnesiumandvitamin-Darethemacronutrientsforbone.Calciumisusedasapharmacologicalagentinhumansalmostentirelytoremedydeficiency.Adequatecalciuminthebloodissovitaltoawidevarietyofbodilyfunctionsthatourinternalbiochemistrywillnottolerateadeficiencyevenforshortperiods.Clinicalevidencesuggeststhatcalciumisusefulforthepreventionandtreatmentofosteoporosisandassociatedfractures.Vitamin-DisalsoessentialforhealthybonesasitaidsincalciumabsorptionfromtheGItract.Inadditiontothisitstimulatesboneformation.Clinicalstudiesshowthatcalciumandvitamin-Dhassynergisticeffectsonbonegrowthaswellasinosteoporosisandfractureprevention.Magnesiumalsoincreasesbonestrengthandrigidity.Somemicronutrientslikecopper,manganese,zincandboronalsoplayimportantroleinbonehealth.

Ostogen Plus
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Ostogen Plus
Generic	Calcium + Vitamin D3 + Multimineral
Weight	n/a
Type	Tablet
Therapeutic Class	Specific mineral & vitamin combined preparations
Manufacturer	Opsonin Pharma Ltd, Opsonin Pharma Ltd,
Available Country	Bangladesh
Last Updated:	September 19, 2023 at 7:00 am

Uses

This preparation is used for- Prevention and treatment of osteoporosis; To maintain strong bone growth and teeth; For proper functioning heart, muscle and nerves; As nutritional supplement; For bone development and constant regeneration of bone; Pregnancy & lactation; Deficiency state of calcium, vitamin D, magnesium, zinc, copper, manganese & boron

Ostogen Plus is also used to associated treatment for these conditions: Calcium Deficiency, Deficiency, Vitamin D, Osteodystrophy, Osteomalacia, Osteoporosis, Chronic Hypocalcemia, Chronic Hypocalcemia caused by anticonvulsant medications, Care of the Joint, Mineral supplementation, Nutritional supplementation

How Ostogen Plus works

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.

Dosage

Ostogen Plus dosage

Adults, Elderly and children above 12 years of age: 2 tablets per day, preferably one tablet each morning and evening.

Children below 12 years of age: Not recommended.

Side Effects

Orally administered calcium carbonate may be irritating to the GI tract. It may also cause constipation. Hypercalcemia is rarely produced by administration of calcium alone, but may occur when large doses are given to patients with chronic renal failure. Also there may be allergic reactions, irregular heartbeats, nausea, vomiting, decreased appetite dry mouth and drowsiness. Following administration of vitamin-D supplements occasionally skin rash has been reported. Side effects from micro nutrients are rare.

Precaution

Patients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully. Periodic checks of plasma calcium levels and urinary calcium excretion should be made in patients with mild to moderate renal failure or mild hypercalciuria.

Interaction

It has possible interaction with digoxin, antacids containing calcium, aluminum or magnesium, other calcium supplements, calcitriol or other vitamin-D supplements; tetracycline, doxycycline, aminocycline or oxytetracycline etc. So before taking any of these drugs consultations of the physicians are needed.

Elimination Route

The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.

Pregnancy & Breastfeeding use

Usually should be used considering the risk benefit ratio.

Contraindication

Hypercalcemia and hyperparathyroidism, Hypercalciuria and nephrolithiasis, Hypersensitivity to the component of Ostogen Plus, Severe renal insufciency, Concomitant digoxin therapy.

Acute Overdose

Symptoms of overdose may include nausea and vomiting, severe drowsiness, dry mouth, loss of appetite, metallic taste, stomach cramps, unconsciousness, diarrhea, weakness, headache, constipation, dizziness or irritability.