Otiwax
Otiwax Uses, Dosage, Side Effects, Food Interaction and all others data.
Benzocaine, an ester local anaesthetic, blocks the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to Na ions, which results in inhibition of depolarisation with resultant blockade of conduction.
Benzocaine is indicated for use as a topical anesthetic. It has a duration of action of approximately 10 minutes and a wide therapeutic window. Patients should be counselled regarding the risks of methemoglobinemia.
Turpentine, also known as spirit of turpentine, oil of turpentine, and wood turpentine, is a liquid extracted from live trees, mainly pine, through distillation of resin. It is used as a solvent and base material in organic synthesis reactions. Turpentine is composed of terpenes, mainly the monoterpenes alpha-pinene and beta-pinene with lesser amounts of carene, camphene, dipentene, and terpinolene.
Turpentine oil, when inhaled, may help reduce congestion. When used on the skin, turpentine oil may cause warmth and redness that can help relieve pain in the tissue underneath.
Trade Name | Otiwax |
Generic | Benzocaine + Chlorbutol + Paradichlorobenzene + Turpentine |
Type | Ear Drops |
Therapeutic Class | |
Manufacturer | Alembic Pharmaceuticals |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
![Otiwax Otiwax](https://www.medicinesfaq.com/media/png/otiwax.png)
Uses
For the temporary relief of pain due to minor injury or irritation of the mouth and gums like Toothache, Sore gums, Canker sores, Braces, Minor dental procedures, Dentures
Turpentine is a medication used to treat minor aches and pains of muscles and joints.
Turpentine has been used experimentally in a bath for the treatment of disseminated sclerosis and sexual dysfunction. It also has been studied for its antibacterial activity and inhibition of osteoclast activity. Turpentine is utilized in experimental models of inflammation to induce a systemic inflammatory immune response in animals.
Otiwax is also used to associated treatment for these conditions: Acute Sore Throat Pain, Dental Pain, Gangrene Stomatitis, Gingivitis, Hemorrhoids, Laryngitis, Pharyngitis, Premature Ejaculation, Secondary Bacterial Infection caused by Tonsillectomy, Secondary Bacterial Infection caused by Tooth Extractions, Skin Irritation, Sore Throat, Stomatitis, Sunburn, Teething pain, Tonsillitis, Tooth Pain, Vomiting, Pruritic dermatosis, Ulceration of the mouth, Buccopharyngeal anesthesiaJoint Pain, Soreness, Muscle
How Otiwax works
Benzocaine diffuses into nerve cells where it binds to sodium channels, preventing the channels from opening, and blocking the influx of sodium ions. Nerve cells unable to allow sodium into cells cannot depolarize and conduct nerve impulses.
Binding of turpentine oil or inflammatory cytokines e.g. interleukin-1 (IL-1) activate signalling through the IL-1 Type 1 receptor (IL-1 R1). Initiation occurs by binding of Toll-interleukin 1 receptor adaptor protein (TIRAP) and Myeloid differentiation primary response gene 88 (mD88) which then dissociates and interacts with IRAK (Interleukin 1 receptor associated kinase) and the tumour necrosis factor receptor associated factor 6 (TRAF6). This activates the MAPK pathway leading to transcription of the nuclear factor κB transcription factor and production of inflammatory mediators.
Dosage
Otiwax dosage
Apply to the affected area up to 4 times daily or as directed by a doctor/dentist. Children under 12 years of age should be supervised during the use of this product. Children under 2 years of age should be consulted to a doctor/dentist prior to the use of this product. An easy application might be done by fixing applicator on the tube’s nozzle. After application, supplied cap should be fixed on top of the applicator.
Side Effects
Side effects are less common. The side effects include allergies, swelling in the mouth or throatetc.
Toxicity
Patients experiencing an overdose may present with local anesthetic systemic toxicity syndrome, decreased cardiovascular function, decreased central nervous system function, cardiac arrest, bradycardia, hypotension, cardiac arrhythmias, syncope, and seizures. Patients should be treated with symptomatic and supportive measures which include airway maintenance, controlling seizures, and hemodynamic stabilization.
Human : TCLo ( Inhalation) 175ppm, Effects : lung, Thorax or Respiration Human: TCLo ( inhalation ) 6gm/m3/3h , Effects : Behavioral: Headache Infant: LDLo ( Oral ) 1748 mg/kg, Effect : GI, Nausea or vomiting Man: LDLo (Oral ) 3mg/kg Mouse LC50 ( inhalation ) 29mg/m3/2h Mouse: LD50 ( intravenous ) 1180ug/kg Rabbit: LDLo ( Skin) 5010mg/kg, Effect: general depressed activity
Precaution
Patient with asthma, bronchitis, emphysema, heart disease; smokers. Children, Pregnancy and lactation.
Interaction
May antagonise the therapeutic effect of sulfonamides. Anticholinesterases may inhibit the metabolism benzocaine.
Volume of Distribution
Turpentine, as a lipophilic substance, accumulates in fatty tissues. The highest concentrations of turpentine following inhalation by rats were found in the spleen, kidneys, brain, and peripheral and perinephric fat.
Elimination Route
Turpentine is readily absorbed from GI tract, skin, and respiratory tract.
Half Life
Eight male volunteers were exposed to 450 mg/cu m turpentine by inhalation (2 hr, 50 W) in an exposure chamber. The mean half lives of the last phase of alpha-pinene, beta-pinene, and 3-carene (components of turpentine) averaged 32, 25, and 42 hours, respectively.
Elimination Route
Elimination of absorbed turpentine in the urine is manifested by an odor resembling that of violets.
Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
Contraindication
Epiglottis (oral spray), methaemoglobinaemia.
Acute Overdose
Symptom: Methaemoglobinaemia, manifested by cyanotic (greyish) skin discolouration, unusual breathing or breathlessness.
Management: Symptomatic and supportive treatment. IV methylene blue 1% may be administered.
Storage Condition
Store between 15-30° C.
Innovators Monograph
You find simplified version here Otiwax