Ouabain

Ouabain Uses, Dosage, Side Effects, Food Interaction and all others data.

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase.

Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

Trade Name Ouabain
Generic Ouabain
Ouabain Other Names G-Strophanthin, Ouabagenin L-Rhamnoside, Ouabagenin-L-rhamnosid, Ouabaine, Oubain
Type
Formula C29H44O12
Weight Average: 584.6525
Monoisotopic: 584.283276872
Protein binding

60%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Ouabain
Ouabain

Uses

For the treatment of atrial fibrillation and flutter and heart failure

How Ouabain works

Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

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*** Taking medicines without doctor's advice can cause long-term problems.
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