Ovagain Plus
Ovagain Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are shown to regulate insulin by promoting glucose utilization and increasing the sensitivity of the insulin receptor .
Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and with decreased symptom severity.
Although it has been nasally administered for treating the common cold, this route of administration has been associated with some cases of anosmia , , , .
Studies show that zinc may be better absorbed in humans in the gluconate form , , however, results from other studies may vary , [L27280].
| Trade Name | Ovagain Plus |
| Generic | Chromium Picolinate + Vitamin D3 / Cholecalciferol + Mecobalamin + Myo-inositol / Inositol + Zinc Gluconate + Pyridoxal-5-phosphate + Alpha Lipoic Acid + D-chiroinositol + L-methylfolate |
| Weight | 200mcg |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | Aube Life Science |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Mecobalamin is used for-
- Peripheral Neuropathies
- Diabetic Neuropathy
- Verteberal Syndrome
- Nerve Compression Syndrome
- Multiple sclerosis
- Amyotrophic lateral sclerosis
- Parkinson’s disease
- Alzheimer’s disease
- Diabetic retinopathy
- Entrapment neuropathy
- Drug induced neuropathy
- Megaloblastic anemia due to Vitamin B12 deficiency
Zinc gluconate is an ingredient found in a variety of supplements and vitamins.
Zinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea .
Ovagain Plus is also used to associated treatment for these conditions: Nutritional supplementationVitamin B12 Deficiency, Nutritional supplementationZinc Deficiency
How Ovagain Plus works
Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV) .
Dosage
Ovagain Plus dosage
Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.
Injection:
- Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
- Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy
Side Effects
Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.
Toxicity
Nausea, vomiting, diarrhea, and mouth irritation have been reported in patients ingesting zinc gluconate tablets that were dissolved in the mouth for management the common cold .
Zinc crosses the placenta and is found the cord blood and placenta. Fetal concentrations are regulated by the placenta .
For more information, refer to Please refer to DrugBank entry Zinc.
Acute: 1290 mg/kg in mouse
Precaution
The medicine should not be used for months if there is no response at all after its use for a certain period of time.
Interaction
Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
Volume of Distribution
Stored primarily in skeletal muscle and bone .
Elimination Route
Please refer to DrugBank entry Zinc
Half Life
280 days
Clearance
Please refer to DrugBank entry Zinc
Elimination Route
Feces and urine
Pregnancy & Breastfeeding use
Not recommended during pregnancy & lactation.
Contraindication
Hypersensitivity to any component of this product.
Special Warning
Use in children: Not recommended.
Storage Condition
Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Innovators Monograph
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