Oxacilina

Oxacilina Uses, Dosage, Side Effects, Food Interaction and all others data.

An antibiotic similar to flucloxacillin used in resistant staphylococci infections.

Oxacilina is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Oxacilina has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Oxacilina results from the inhibition of cell wall synthesis and is mediated through Oxacilina binding to penicillin binding proteins (PBPs). Oxacilina is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Trade Name Oxacilina
Availability Prescription only
Generic Oxacillin
Oxacillin Other Names Ossacillina, Oxacilina, Oxacillin, Oxacilline, Oxacillinum, Oxazocillin, Oxazocilline
Related Drugs amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin
Type
Formula C19H19N3O5S
Weight Average: 401.436
Monoisotopic: 401.104541423
Protein binding

94.2 +/- 2.1% (binds to serum protein, mainly albumin)

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Oxacilina
Oxacilina

Uses

Oxacilina is a penicillin antibiotic used to treat a number of susceptible bacterial infections.

Used in the treatment of resistant staphylococci infections.

Oxacilina is also used to associated treatment for these conditions: Catheter Related Infections, Community Acquired Pneumonia (CAP), Infections caused by penicillinase-producing staphylococci, Necrotizing Soft Tissue Infections, Surgical Site Infections

How Oxacilina works

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacilina inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacilina interferes with an autolysin inhibitor.

Food Interaction

No interactions found.

[Moderate] ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food.

The therapeutic effect of the antimicrobial may be reduced.



MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals.

Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.

Oxacilina Hypertension interaction

[Moderate] Each gram of parenteral oxacillin sodium contains approximately 64 to 71 mg (2.8 to 3.1 mEq) of sodium and is buffered with 40 mg of dibasic sodium phosphate.

Each 250 mg capsule of oxacillin sodium contains approximately 16 mg (0.7 mEq) of sodium, and each teaspoonful of the 250 mg<5 mL oral solution contains approximately 18 mg (0.8 mEq) of sodium.

The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

In addition, hypokalemia has been reported rarely during therapy with the penicillinase-resistant penicillins, which may be particularly important to bear in mind when treating patients with low potassium reserves or fluid and electrolyte imbalance.

Clinical monitoring of electrolytes is recommended if these agents are used for prolonged periods.

Half Life

20 to 30 minutes

Elimination Route

Oxacilina Sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion.

Innovators Monograph

You find simplified version here Oxacilina

*** Taking medicines without doctor's advice can cause long-term problems.
Share