Oxizoic
Oxizoic Uses, Dosage, Side Effects, Food Interaction and all others data.
Cream contains the antifungal active compound Oxizoic Nitrate. For topical dermatological use only. Oxizoic Nitrate is an imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has in vitro activity against a wide range of pathogenic fungi. Oxizoic has been shown to be active against most strains of the following organisms both in vitro and in clinical infections at indicated body sites: Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, Malassezia furfur. Oxizoic exhibits satisfactory in vitro minimum inhibitory concentrations (MICs) against most strains of the following organisms: Microsporum audouini, Microsporum canis, Microsporum gypseum, Trichophyton tonsurans,Trichophyton violaceum.
Oxizoic is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur.
Trade Name | Oxizoic |
Generic | Oxiconazole |
Oxiconazole Other Names | Oxiconazol, Oxiconazole, Oxiconazolum |
Type | Cream |
Formula | C18H13Cl4N3O |
Weight | Average: 429.12 Monoisotopic: 426.9812729 |
Groups | Approved |
Therapeutic Class | Topical Antifungal preparations |
Manufacturer | Bdr Pharmaceuticals International Pvt, L |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Oxizoic cream is used for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum. Oxizoic Cream is used for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur.
Oxizoic is also used to associated treatment for these conditions: Fungal skin infection, Pityriasis versicolor, Tinea Corporis, Tinea Cruris, Tinea Pedis
How Oxizoic works
Oxizoic inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxizoic has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oxizoic can increase membrane permeability to zinc, augmenting its cytotoxicity.
Dosage
Oxizoic dosage
Cream should be applied to affected and immediately surrounding areas once to twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. OxizoicCream should be applied once daily in the treatment of tinea (pityriasis) versicolor. Tinea corporis, tinea cruris, and tinea (pityriasis) versicolor should be treated for 2 weeks and tinea pedis for 1 month to reduce the possibility of recurrence.
Use Oxizoic cream as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth, and other mucous membranes. Oxizoic cream isfor external use only.
Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after 2 to 4 weeks orsooner if the condition worsens.
Inform the physician if the area of application shows signs of increased irritation, itching, burning, blistering, swelling, or oozing.
Avoid the use of occlusive dressings unless otherwise directed by the physician.
Do not use this medication for any disorder other than that for which it was prescribed
Side Effects
Pruritus, burning, irritation and allergic contact dermatitis, folliculitis, erythema, and papules, fissure, maceration, rash, stinging and nodules.
Toxicity
Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.
Precaution
Oxizoic cream is not for ophthalmic or intravaginal use.
Interaction
Potential drug interactions between Oxizoic and other drugs have not been systematically evaluated.
Food Interaction
No interactions found.Elimination Route
Systemic absorption of oxiconazole is low.
Pregnancy & Breastfeeding use
Pregnancy category B. Because Oxizoic Nitrate is excreted in human milk, caution should be exercised when the drug is administered to a nursing woman.
Contraindication
Oxizoic cream is contraindicated in individuals who have shown previous hypersensitivity to Oxizoic
Storage Condition
Store in a cool and dry place,protected from light. Do not freeze.
Innovators Monograph
You find simplified version here Oxizoic
Oxizoic contains Oxiconazole see full prescribing information from innovator Oxizoic Monograph, Oxizoic MSDS, Oxizoic FDA label