Oxysite Plus
Oxysite Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Astaxanthin acts as an antioxidant by dual mode of action. It suppresses singlet oxygen and also inhibits lipid peroxidation. By these actions it reduces the harmful free radicals. Therefore acts as a very strong antioxidant. Astaxanthin is absorbed by passive diffusion into the intestinal epithelium alongside fatty acids. Then it is incorporated into lipoproteins, transported to the liver, via lymph and blood and partly resecreted with lipoproteins. More than 70% of the Astaxanthin is contained in high-density lipoprotein part of plasma. Highest concentration of Astaxanthin is in the small intestine, followed by subcutaneous fat, spleen, liver, heart, kidney and skin and lowest in the muscles.
Cupric oxide, or copper (II) oxide, is an inorganic compound with the chemical formula CuO. Cupric oxide is used as a precursor in many copper-containing products such as wood preservatives and ceramics. Cupric oxide may be found in over-the-counter vitamin-mineral supplements as a source of Copper. The mean daily dietary intake of copper in adults ranges between 0.9 and 2.2 mg . Common routes of cupric oxide exposure include ingestion, dermal exposure and inhalation. Copper(II) oxide nanoparticles (NPCuO) have industrial applications as antimicrobial agents in textiles and paints, and catalysts in organic synthesis . They may also be produced from electronic wastes. Cupric oxide poses potential health and environmental concern due to toxic and mutagenic particles generating reactive oxygen species .
For pharmacodynamic information of copper, refer to drug entry for Copper. Copper(II) oxide nanoparticles are known to generate reactive oxygen species (ROS), leading to cytotoxicity . In a comparative toxicity assay, nanoparticles caused significant mitochondrial depolarization leading to DNA damage . In the human skin organ culture study, topical application of copper oxide (CuO) nanoparticles induced inflammatory cytokine secretion and necrosis in vitro, indicating that the nanoparticles may adhere to the skin surface and react with the local acidic environment .
Lutein is an xanthophyll and one of 600 known naturally occurring carotenoids. Lutein is synthesized only by plants and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots. In green plants, xanthophylls act to modulate light energy and serve as non-photochemical quenching agents to deal with triplet chlorophyll (an excited form of chlorophyll), which is overproduced at very high light levels, during photosynthesis.
Lutein was found to be present in a concentrated area of the macula, a small area of the retina responsible for central vision. The hypothesis for the natural concentration is that lutein helps protect from oxidative stress and high-energy light. Several studies show that an increase in macula pigmentation decreases the risk for eye diseases such as Age-related Macular Degeneration (AMD).
Zeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some micro-organisms. It gives the distinct yellow color to many vegetables and other plants including paprika, corn, saffron and wolfberries. Zeaxanthin is one of the two primary xanthophyll carotenoids contained within the retina of the eye and plays a predominant component in the central macula. It is available as a dietary supplement for eye health benefits and potential prevention of age-related macular degeneration. Zeaxanthin is also added as a food dye.
Zinc oxide is used to treat or prevent minor skin irritations such as burns, cuts, poison ivy, poison oak, poison sumac, and diaper rash. It is also used as a sunscreen.
Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations, wounds and haemorrhoids. It also reflects ultraviolet radiation and can be used as a physical sunscreen.
| Trade Name | Oxysite Plus |
| Generic | Vitamin C / Ascorbic Acid + Bilberry Extract + Pine Bark Extract + Zinc Oxide + Lutein + Vitamin E / Tocopherol + Astaxanthin + Zeaxanthin + Cupric Oxide + Vitamin A / Retinol + Elemental Selenium |
| Weight | 40mg |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | Neomedix |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Astaxanthin is used to-
1. Strong antioxidant
2. Improves cardiovascular health (Atherosclerosis, reduce cholesterol).
3. Improves immune function.
4. Improves condition of skin
5. Protects skin from damage caused by sun (Reduce wrinkles, pimples and other signs of aging)
6. Improves recovery from central nervous system injuries
7. Protects from Parkinson ’s disease, Dementia and Alzheimer\'s
8. Protects eyes from cataracts and macular degeneration.
9. Reduces inflammation (Arthritis)
10. Reduces risk of infertility
Also Astaxnthin effectively reduce oxidative damage to DNA, decrease the risk for many types of cancer and stabilize blood sugar.
Cupric oxide is an ingredient found in a variety of supplements and vitamins.
No FDA- or EMA-approved therapeutic indications.
Xanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance.
Zinc Oxide helps to To treat or prevent skin irritations (e.g., burns, bed sore, cuts, poison ivy, diaper rash). Protects chafed skin due to diaper rash and helps seal out wetness.
Oxysite Plus is also used to associated treatment for these conditions: Folate supplementation therapy, Mineral supplementation, Nutritional supplementation, Vitamin supplementationMineral supplementation, Oral Nutritional Supplementation, Vitamin supplementationAcute Wounds, Burns first degree, Burns second degree, Dermatitis, Eczematous, Diaper Rash, Herpes Labialis, Injuries to the Nipple (Fissures and Cracks) Resulting Breastfeeding, Intertrigo, Pain, Pruritus, Sensitive Skin, Skin Irritation, Skin candida, Sunburn, Wounds, Chafing, Damaged skin, Dry, cracked skin, Facial rash, Heat rash, Superficial Wounds, Watery skin lesions, Astringent, Nutritional supplementation
How Oxysite Plus works
For pharmacodynamic information of copper, refer to drug entry for Copper. Copper(II) oxide nanoparticles generate DNA-damaging reactive oxygen species at the nanoparticle surface or in solution by copper dissolved from the nanoparticle surface via Fenton-like reactions . In presence of H2O2, ascorbate, or both, copper (II) oxide generates hydroxyl radical, ascorbyl radical, and superoxide anion that interact with DNA, proteins, and lipids cause oxidative damage and cell death .
Xanthophylls have antioxidant activity and react with active oxygen species, producing biologically active degradation products. They also can inhibit peroxidation of membrane phospholipids and reduce lipofuscin formation, both of which contribute to their antioxidant properties. Lutein is naturally present in the macula of the human retina. It filters out potentially phototoxic blue light and near-ultraviolet radiation from the macula. The protective effect is due in part, to the reactive oxygen species quenching ability of these carotenoids. Lutein is more stable to decomposition by pro-oxidants than are other carotenoids such as beta-carotene and lycopene. Lutein is abundant in the region surrounding the fovea, and lutein is the predominant pigment at the outermost periphery of the macula. Zeaxanthin, which is fully conjugated (lutein is not), may offer somewhat better protection than lutein against phototoxic damage caused by blue and near-ultraviolet light radiation. Lutein is one of only two carotenoids that have been identified in the human lens, may be protective against age-related increases in lens density and cataract formation. Again, the possible protection afforded by lutein may be accounted for, in part, by its reactive oxygen species scavenging abilities. Carotenoids also provide protection from cancer. One of the mechanisms of this is by increasing the expression of the protein connexin-43, thereby stimulating gap junctional communication and preventing unrestrained cell proliferation.
It acts by providing a physical barrier to prevent skin irritation and help heal damaged skin.
Dosage
Oxysite Plus dosage
Adults (18 years and older) - Daily dose is 4mg. should be taken along with or immediately prior to meals in the morning.
Different dose for various use are given below:
4 mg: Used as a strong antioxidant, improves cardiovascular health (Atherosclerosis, reduce cholesterol), improves immune function.
4-8 mg: Improves condition of skin, protects skin from sun damage (Reduce wrinkles, pimples and other signs of aging), improves recovery from central nervous system injuries and protects eyes from cataracts and macular degeneration.
8-12 mg: Reduces inflammation (Arthritis)
16 mg: Reduces risk of infertility
Apply thin layer topically every 8 hourly. Change wet and soiled diapers, promptly cleans the diaper area, allow to dry and apply ointment liberally as often as necessary, with each diaper change, especially at bedtime or any time when exposure to wet diapers may be prolonged.
Side Effects
No severe side effects have been reported yet
Usually well tolerated. Extremely low frequency of hypersensitivity reaction.
Toxicity
Copper toxicity involves gastrointestinal irritation and liver and kidney toxicity. Reported No-Observed-Adverse-Effect-Levels (NOAELs) of copper are in the range of 23-104 mg/kg bw/day, but kidney effects have been shown in male rats at levels as low as 10 mg/kg bw/day . Severe intoxication is associated with serum copper levels greater than 500 mcg/dL. The estimated lethal dose in an untreated adult is 10 to 20 g copper .
Acute oral toxicity (LD50): 7950 mg/kg [Mouse].
Precaution
Pregnant women and nursing mothers should avoid Astaxanthin containing supplements.
For external use only. Avoid contact with the eyes. Stop use and ask a doctor if condition worsens or does not improve within 7 days. Keep out of the reach of children. If swallowed, get medical help or contact a poison control center right away
Interaction
Concomitant intake of Astaxanthin with Cholestyramine, Colestipol, Mineral oil, Orlistat may reduce the absorption rate of Astaxanthin
Volume of Distribution
Following exposure to cupric oxide aerosols containing 50-80 mg/m^3 in rats, particles were found in plasma 6 hours post-exposure and copper oxide was also observed in the proximal convoluted tubules of the kidney .
Intended for local use only, no systemic absorption.
Elimination Route
Following oral administration, copper is mainly absorbed through the gastrointestinal tract from the stomach, duodenum, and jejunum. All other intakes of copper (inhalation and dermal) are insignificant in comparison to the oral route. The bioavailability of copper from cupric oxide depends on the solubilization of the oxide in the gastrointestinal tract . According to studies on cattle and swine, copper oxide displays low absorption rate and high excretion rate . In rats exposed to aerosols containing 50-80 mg/m^3, pulmonary uptake of copper oxide occurred .
No significant percutaneous absorption from topically applied zinc oxide.
Half Life
No pharmacokinetic data available.
Intended for local use only, no systemic absorption.
Clearance
No pharmacokinetic data available.
Intended for local use only, no systemic absorption.
Elimination Route
Copper undergoes biliary excretion .
Intended for local use only, no systemic absorption.
Pregnancy & Breastfeeding use
Both pregnant women and lactating mothers should avoid Astaxanthin supplements as no data on safety has been found yet
This medication should be used with precautions only if clearly needed during pregnancy or while breast feeding
Contraindication
Contraindicated for those with known allergies to Astaxanthin
Known hypersensitivity to any component of the preparation
Acute Overdose
No case of overdose has occurred with Astaxanthin
No overdose related problem is yet reported.
Storage Condition
Store in cool and dry place, away from direct light. Keep out of reach of children.
keep in a cool and dry place, away from light.
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